Thanks for the feedback, dear Rebecca! I already miss that GRC Meeting in Lucca! 🥹

Thanks for the recognition. I am really honored to work in this lab which promotes collaboration and a thriving environment for research 🔬🧑‍🔬👩‍🔬

I am so happy to share that my previous preprint is officially out as a Report in JCB. 🩵

Hop in to find out more about how cells move as an invasive cluster 🧬

All in all, RhoGAP15B locally suppresses RhoA–Myosin II at the leading edge, creating a relaxed cortical zone that stabilises protrusions while possibly helping to dictate the cycles of contractility/extension, thereby setting the pace for migration.

RhoA activity (measured with a FRET sensor) is increased with RhoGAP15B RNAi. While there is normal rear–front asymmetry in migrating border cell clusters, the loss of RhoGAP15B leads to elevated, spatially uniform RhoA activity, consistent with excessive cortical Myosin-driven contractility.

RhoGAP15B:GFP shows predominantly cortical localisation, with enrichment at the outer cortex. Within the leader cell, RhoGAP15B concentrates at the leading edge and is largely excluded from the nucleus and cytoplasm, consistent with a role in locally modulating RhoA–Myosin II at the migration front.

RhoGAP15B RNAi collapses leader protrusions, while RhoGAP15B OE stabilises and extends them, underscoring tight control protrusion dynamics.

How do migrating cell groups balance force and flexibility?

Our new preprint shows that RhoGAP15B downregulates RhoA–Myosin activity to stabilise protrusions and enable efficient collective migration in vivo.

Happy New Year!

www.biorxiv.org/content/10.6...

#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules

#Cancer cells switch strategies during metastasis to invade other tissues

Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social

XXXI Porto Cancer Meeting
📅14-16 May 2025
📍#i3S

This year's Porto #Cancer Meeting will focus on the intricacies of cancer cell connections and their implications in cancer development and progression.
Abstract submission⏰4 Febr
Early registration⏰3 Mar
➕ lnkd.in/dM-aWvWn

Porto is a beautiful during spring (it is all year around but I may be biased)!

And is hosting the conference that you don't want to miss on #adhesion regulation in #cancer. A great lineup of speakers from basic to clinical research and also many talk opportunities. Check it out and join us!

Thank you so much! 🪰

It's always mesmerizing seeing how these group of cells move.

ℹ️Border cells invading through nurse cells
ℹ️Drosophila S9 egg chambers

Egg Chamber from fruit fly ovary 🪰