Research in Progress “Linking HIV-Nef protein cargo in extracellular vesicles to cardiovascular comorbidities: Multiomics profiling reveals epigenetic mechanisms of Nef‑mediated macrophage dysfunction” presented Monday April 27 (12:30 pm US ET) by Sarvesh Chelvanambi, PhD (Brigham and Women’s Hospital, Harvard Medical School)

📢 @sarveshchelvanambi.bsky.social cics.bwh.harvard.edu presents 🦠🫀"Linking #HIV-Nef protein cargo in extracellular vesicles to #cardiovascular comorbidities... " ℹ️Info@ mailchi.mp/harvard/rese... @mgb-id.bsky.social @mgb-id-fellows.bsky.social @tuftsmedschool.bsky.social @harvardepi.bsky.social

Just *two weeks* until the start of Infectious Diseases in Adults 2026, brought to you by Massachusetts General Hospital and Harvard Medical School! We're thrilled to see how many learners have enrolled and welcome even more!

Register at: learn.hms.harvard.edu/id

Travel After Transplant: Demographics, Travel Trends, and... : Transplantation actices at pretravel health consultations of immunocompromised posttransplant travelers (IPTTs) seen at 17 US clinical sites from January 2009 to December 2023. Methods. Travelers and providers completed an online structured questionnaire during the pretravel health consultation. For this analysis, we compared the demographics, travel itinerary, and vaccination practice of IPTTs with frequency-matched control travelers, using descriptive statistics Results. A total of 317 IPTTs and 3173 control travelers were included. Of the 317 IPTTs, 143 (45%) were women; the median age was 54 y (42–63). Visiting friends or relatives (16.4% versus 6.2%, P < 0.001) and cruise ship travel (12.9% versus 8.0%, P = 0.003) were more frequently reported among individuals with IPTTs than among controls. No IPTT received the measles-mumps-rubella vaccine; 1 IPTT received the yellow fever vaccine. Conclusions. This is the largest described cohort of IPTTs. Understanding travel patterns and vaccination practices in this higher-risk population is crucial to improving pretravel preparation and outcomes....

journals.lww.com/transplantjo...

A call for shared digital infrastructure in travel medicine: the travel health data commons Travel medicine needs shared digital standards and resources. We propose a Travel Health Data Commons (THDC) encompassing consensus case definitions, commo

academic.oup.com/jtm/article-...

Xenotransplantation and Human Organ Trafficking: The Impact of Increased Organ Availability The global shortage of organs for allotransplantation contributes to illicit trade in human organs. While clinical xenotransplantation is proposed as a potential solution to this global shortage, div....

onlinelibrary.wiley.com/doi/10.1111/...

Costimulatory blockade and infectious risk in solid organ transplantation Costimulatory blockade has emerged as a promising alternative to conventional immunosuppression with the potential to reduce chronic allograft injury and minimize drug-related toxicities, including ne...

www.amjtransplant.org/article/S160...

Quantifying brain-age gap in people with HIV on... : AIDS ls in the general population. Design: Secondary analysis of the multicenter observational cohort study (ACTG HAILO) involving older, cognitively unimpaired PWH on antiretroviral therapy (ART). Methods: Plasma NfL concentrations were quantified using the Quanterix® Simoa assay in 340 PWH aged ≥45 years. Values were compared with two age-stratified reference standards from cognitively unimpaired general-population controls. The brain-age gap was estimated using a generalized logistic model with repeated measures so that 5% of observed NfL concentrations in PWH would exceed the reference upper 95th percentile for the imputed age. Results: Median plasma NfL concentration was 10.1 pg/mL (IQR: 7.4–13.5). Using Simrén et al. standards, 24.1% (95% CI: 19.8–29.0) of observed values exceeded the age-specific upper 95th percentile, and 10.0% (95% CI: 7.2–13.7) using Bornhorst et al. standards. Model-based results suggested brain age was 11.0 years (95% CI: 9.1–13.7) or 6.4 years (95% CI: 5.1–8.5) higher than chronological age, depending on the standard. The estimated brain-age gap was significantly greater in individuals with subsequent cognitive decline than in those without (Simrén: 13.0 vs. 8.4 years; Bornhorst: 7.6 vs. 5.0 years). Conclusion: Plasma NfL reflects a substantial brain-age gap in cognitively unimpaired PWH on ART, supporting evidence of advanced aging. The brain-age gap was higher in PWH with subsequent cognitive decline. Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc....

journals.lww.com/aidsonline/a...

Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults with HIV: preliminary pilot data from a randomized clinical trial - Naunyn-Schmiedeberg's Archives of Pharmacology We report preliminary safety and tolerability data from 66 persons living with HIV (PLWH) (≥ 18 years old) who received escalating dosages of lisinopril or matched placebo, in addition to antiretrovir...

link.springer.com/article/10.1...

Performance of a Sepsis Prediction Model Across Different Sepsis Definitions This diagnostic study evaluates an early detection of sepsis prediction model using multiple standard sepsis definitions among adults in the northeastern US.

jamanetwork.com/journals/jam...

Understanding the clinical implications of the barrier against resistance in antiretroviral treatment Josep M Llibre, Daniel R Kuritzkes, Raquel Martin-Iguacel, Diego Ripamonti, Ravindra K Gupta, Paul E Sax, Jonathan M Schapiro, Robert W Shafer, Thibault Me

academic.oup.com/cid/advance-...

Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply The geographic distribution of hospitalized severe malaria cases in the US is heterogeneous, but a subset of US counties experience consistently higher cas

academic.oup.com/cid/advance-...

High agreement of Seegene Anyplex™ HPV 28 and Allplex™ HPV 28 for high-risk vaccine-type HPV detection in the KEN SHE Study The KEN SHE Study replaced Anyplex™ II HPV28 Detection multiplex real-time PCR kits (Anyplex) with Allplex™ HPV28 kits (Allplex) mid-study. Assay comp…

www.sciencedirect.com/science/arti...

Have you registered for #IDinAdults2026? If so, submit your HIV or mycobacterial infection case to be discussed during our Meet the Professors sessions! Follow the link in the email you received from HMS.

Not registered yet? There's still time! learn.hms.harvard.edu/id

Analogue insulin, GLP-1, and the WHO Model Essential Medicines List David Beran and colleagues argue that the GLP-1 receptor agonists might not have been appropriate for addition to the 2025 WHO Essential Medicines List (EML) for three reasons.e First, the authors sta...

www.thelancet.com/journals/lan...

Red Blood Cell Exchange Transfusion for Severe Babesiosis This multicenter cohort study evaluates whether red blood cell exchange transfusion improves clinical outcomes among hospitalized adult patients with severe babesiosis.

jamanetwork.com/journals/jam...

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab Abstract. This article provides a focused update to the clinical practice guideline on the treatment and management of patients with COVID-19, developed by

academic.oup.com/cid/advance-...

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults Abstract. This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by t

academic.oup.com/cid/advance-...

Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment Yeo et al. use spatial multi-omics to reveal EBV-driven remodeling of the classic Hodgkin lymphoma microenvironment. EBV-positive disease shows CD8 T cell enrichment with terminal exhaustion linked to...

www.cell.com/cell-reports...

Congratulations to Julie Levison, MD, MPhil, MPH, who is the faculty recipient of the 2026 @harvardmed.bsky.social Dean's Community Service Award. The award recognizes the research, clinical, and public health activities with our community partner La Colaborativa in Chelsea, MA. 🤩

Learners at #IDinAdults2026 can discuss their cases with our expert faculty at 4 Meet the Professors sessions on HIV & Mycobacterial Infections. Sessions are scheduled AM & PM to accommodate our global audience.

Register now to submit your case for consideration!

learn.hms.harvard.edu/id

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We do everything we can to help people get out of Box #4.

Every day, our teams work to ensure you and your loved ones are safe and healthy in the places where you live, work, and play. Whether it's an emergency or just another day in your life, your public health department is here for you.

Happy National Public Health Week, Boston!

Two sessions that are not to be missed at #IDinAdults2026!

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All recorded sessions will be available for viewing for 90 days after the end of the course.

Congratulations to Alexis D. Peracchi Liakos, PA-C who won the Massachusetts Association of PAs "PA of the Year" Award!

You are correct in noticing that none of the titles of our talks include the phrase "airborne transmission". This does not mean that it will not be discussed.

Just one more day to register at the discounted rate for Infectious Diseases in Adults 2026!

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Reparations for Caribbean slavery and the potential impact on human well-being The reparations movement has emerged as a critical global force addressing the historical injustices of slavery, colonialism and underdevelopment. Grounded in the 2001 World Conference Against Racism,...

gh.bmj.com/content/11/S...