Vacancy: Professor in Medical Statistics and Academic Lead for Clinical Trials in Oncology, University of Sheffield jobsite.sheffield.ac.uk/job/Professo...

Boston University Seminar: Improving Decision-Making in Oncology Basket Clinical Trials: Challenges of Small Sample Sizes and Heterogeneous Treatment Effects

Presented by Haolin Li

12 May 2026

Zoom
Meeting ID: 998 0913 5732
Passcode: 201194
www.linkedin.com/posts/leohao...

R 4.6.0 "Because it was There" is set for release on 24 April.

@russhyde.bsky.social writes up the more interesting changes — %notin% in base R, neater character column summaries, and more.

Full breakdown with code: www.jumpingrivers.com/blog/whats-n...

#rstats #datascience #rprogramming

New presentation: www.fharrell.com/talk/qrct/ #Statistics #StatsSky #clinicaltrials

A good case study on how:
(1) OS is the most important endpoint in cancer trials
(2) Prespecifying strategy for handling intercurrent events + sensitivity/supplementary analyses are crucial
(3) Above strategies (e.g. ?hypothetical estimand with RPSFT) are not without limitations

among others

Bayesian analysis in confirmatory clinical trials: A narrative review and discussion of current practice - Rebecca M Turner, Conor D Tweed, Trinh Duong, Deborah Ford, Michelle N Clements, Mahesh KB Pa... Background: Bayesian methods allow trial investigators to combine evidence obtained within a clinical trial with relevant evidence that is available outside the...

Bayesian analysis in confirmatory clinical trials: A narrative review and discussion of current practice journals.sagepub.com/doi/full/10....

Holy. Shit. This is Reid Wiseman's video he took with his iPhone while at the moon 🌙

FDA novel oncology drug approvals in 2025

Table includes requirement for randomised dose finding and post-marketing dose optimization

www.parexel.com/insights/blo...

If you would like to get started on oncology trial endpoints and stats, Linh Dinh has collated this nice Wiki here stat-wiki.linhdinh-dl1989.workers.dev

Trials of TIGIT inhibitors as a case study of herding in oncology drug development

bmjoncology.bmj.com/content/5/1/...

Just noted this peculiar approach from survival::quantile.survfit() in estimating median time:

"Since S(t) is a step function, it is possible for the curve to have a horizontal segment at exactly 1-k, in which case the midpoint of the horizontal segment is returned."

?

A guy asking ChatGPT to review a series of fart sound effects and getting a serious kiss ass response that calls it atmospheric

I can't stop laughing at this post. It's perfect.

Causal by Design: new blog article on Statistical Thinking. fharrell.com/post/causal/ #Statistics #StatsSky #EpiSky

Not really, but thanks 😂

Before going to sleep on flight day 5, the Artemis II crew snapped one more photo of the Moon, as it drew close in the window of the Orion spacecraft. Orion and the four humans aboard entered the lunar sphere of influence at 06:37 CEST on 6 April, at the tail end of the fifth day of their mission. That marked the point at which the Moon's gravity had a stronger pull on the spacecraft than Earth's. Artemis II's closest approach to the Moon will come on flight day 6, as they swing around the far side before beginning their journey back to Earth.

✅ #Artemis II update: the spacecraft entered the lunar sphere of influence this morning at 05:37 BST/06:37 CEST, 6 April, at about 51 000 km from the Moon (the region of space where the Moon’s gravitational pull is stronger than that of Earth’s).

www.nasa.gov/image-detail...

@exploration.esa.int

Two recent FDA rejections due to concerns with the unconvincing use of external control arms
onbiostatistics.blogspot.com/2025/11/when...

Charité's @bihatcharite.bsky.social peer review summer course "Peerspectives" is open for applications until April 10: iph.charite.de/en/academic_...

CRUK @cancerresearchuk.org follows! That would save £5.2 million. Will the scholarly publishing practice ever change? news.cancerresearchuk.org/2026/04/01/w...

Clinical Trial Simulation: Planning With the OCTAVE Framework, Implementation and Validation Principles The adoption of complex innovative clinical trial designs has steadily increased in recent years. These are trial designs that have one or more unconventional features—often resulting in multiple sta...

The OCTAVE framework for simulating trials: onlinelibrary.wiley.com/doi/10.1002/...

will be presented @hrb-tmrn.bsky.social via Zoom universityofgalway-ie.zoom.us/webinar/regi...

Apr 16, 2026 01:00 PM (London)

Incidentally Detected Splenomegaly and Risk of Hematologic Cancer and Liver Disease This cohort study evaluates relative and absolute risks of hematologic cancers, cirrhosis, and liver cancer according to spleen length and volume in individuals with incidentally detected splenomegaly.

Incidentally detected spleen length ≥140 mm or volume ≥500 mL was associated with markedly elevated 5-year risk for hematologic cancer, liver cancer, and cirrhosis in adults from Denmark and the UK. ja.ma/4dDEIVc

A Visit with Stephen Senn: Time, Concurrent Controls, and the Bayesian Guidance YouTube video by Berry Consultants

Listen to Scott Berry @statberry.bsky.social hosting Stephen Senn @stephensenn.bsky.social. They discuss adaptive trials www.youtube.com/watch?v=Tnb0...

The graphical representation of clinical trials with particular reference to measurements over time - PubMed Clinical trials are frequently analysed as if they were surveys when they are in fact experiments. In particular the experimental basis of clinical trials is rarely reflected in the graphs which are used to illustrate them. Proposals are made, and illustrated by example, as to how appropriate figure …

So you carried out a controlled clinical trial? Bravo. Make sure you carry out a controlled analysis.
You can bin those within-group standard errors, comparisons back to baselines and dynamite detonator plots for a start.

pubmed.ncbi.nlm.nih.gov/2277879/

PSI The community dedicated to leading and promoting the use of statistics within the healthcare industry for the benefit of patients.

Webinar: Enhancing Clinical Study Reporting with the Estimand Framework

Tuesday 21st April 2026, 14:00 - 15:30 (GMT)
psiweb.org/events/event...

Five tenets for advancing evidence-based precision medicine - Nature Medicine Coral et al. outline five fundamental tenets to promote clinically meaningful, reproducible, scalable and equitable health outcomes through precision medicine.

Five tenets for advancing evidence-based precision medicine
www.nature.com/articles/s41...

Appraising ML prediction models @maartenvsmeden.bsky.social
1) Share model and code
2) Predictors and language
3) Class imbalance & calibration
4) Model validation sample size
5) Is the model clinically useful in practice?
www.jclinepi.com/article/S089...

to bayesian optimal phase 2 designs, to multi-arm, multistage designs, and to adaptive platform designs. Bayesian methods allow designs to be more adaptive, efficient, and ethical by treating more patients with better treatments based on the available information."

2/2

"In oncology, we have witnessed the evolution of early-stage designs from 3 + 3 designs to continual reassessment methods, to bayesian optimal interval designs, and to posterior predictive design. Similarly, late-stage designs have evolved from Simon 2-stage designs,

1/2

Preprint: On the Calibration of Bayesian Success Criteria and Operating Characteristics for Clinical Trials
arxiv.org/pdf/2603.20015

Screenshot of a html report with an embedded table and a separate button to download the data contained in that table.

Cool little package on CRAN for adding a download data button into html files created from your Rmd.

cran.r-project.org/web/packages...

What Makes an Estimand Useful? Guidance on the Choice of Intercurrent Event Strategies While the use of estimands in randomized trials is increasing, there is little guidance on which intercurrent event strategies should be used. The article by Fleming et al. seeks to address this gap....

COMMENTARY: What Makes an Estimand Useful? Guidance on the Choice of Intercurrent Event Strategies @brennankahan.bsky.social @suziecro.bsky.social

onlinelibrary.wiley.com/doi/full/10....