ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA Squair et al. show that ZNFX1 restricts ssRNA virus replication by integrating SF1 helicase activity with dual E3 ligase mechanisms. ATP-dependent RNA binding activates E3 function, driving self-propa...

Receptor clustering is a common theme in viral detection, but whether detection directly hinders genome replication is less clear.

Excited to share the Z in RZ-type E3s: ZNFX1 is an RNA helicase that builds ubiquitin chains leading to aggregates that ensnare viral RNA.

www.cell.com/molecular-ce...

CL3- Research Assistant The Pirbright Institute The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic a...

Interested in high containment work on viruses?

We have an opening at the Pirbright Institute, working on high consequence viruses of livestock and humans in the core CL3 team.
isw.changeworknow.co.uk/pirbright/vm...

🚨Job Alert🚨

Looking for a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists. The postdoc will collaborate with world-class structural biologist Peijun Zhang to understand everything about HIV capsids and how they work via host interactions.

Spread the word!

Congrats Joe and team.

Blizard Institute welcomes world-leading team of virologists

We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations.

www.qmul.ac.uk/blizard/abou...

Virtual Virology 2 July - Three Pirbright PIs. Do join us

Great action photo Matt! Well done Mohamed.

Nice one. Congrats Adam and All.

Virtual Virology is back - our first ever phage session. Do join us...