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Posts by Bede Portz

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These Chimps Began the Bloodiest ‘War’ on Record. No One Knows Why.

These Chimps Began the Bloodiest ‘War’ on Record. No One Knows Why. www.nytimes.com/2026/04/09/s... fascinating

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@ophirshalem.bsky.social or GTFO one of OGs

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My kids have a field trip to Fenway Park that is science focused, followed by the ballgame. There is an option to take the T home. So cool to have the middle schoolers do that.

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i feel like if i was tasked with not starting a war and bringing back US manufacturing jobs, i could have done a better job than this

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This strikes me as very plausible depending on the density of the methylation

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A raw egg rolled off the counter while cooking tonight and my dog ate it, shell and all. He spent the next 15 minutes excitedly walking laps around the kitchen island hoping to find another.

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glam bois gonna glam 2/2

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glam bois gonna glam 1 of 2

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NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...

Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.

link.springer.com/article/10.1...

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It is also so cheap and easy now
to just buy whatever constructs you need that is the safest bet

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A lesson I learned the very hard way in 2008 after making a transgenic fly line in Dave’s lab.

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There are still a few more hours left in today any more papers uo your sleeve?

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Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

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Papers are like buses... You wait for ages, then two come along at once.

Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!

www.nature.com/articles/s41...

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I think there was a lot of pressure here to get this to happen. The review needs to be fair and under tremendous scrutiny

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Lutnick Acknowledges Traveling to Epstein’s Island

Lutnick Acknowledges Traveling to Epstein’s Island www.nytimes.com/2026/02/10/u...

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CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.

Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n

news.cuanschutz.edu/dbmi/cu-ansc...

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Budweiser and Bad Bunny are tied 💯 to 💯 in the Super Bowl.

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www.biorxiv.org/content/10.6...

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The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex prediction - Nature Communications Interactions between long RNA molecules play essential roles in shaping gene regulation. Here, the authors show that low-complexity repeats drive stable contacts between RNAs and present RIME, a deep ...

www.nature.com/articles/s41...

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Too soon.

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www.biorxiv.org/content/10.6...

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Can’t think of a better thing for my kids to see than their mom and her girlfriends singing the late gen X/elder millennial woman’s cannon. Currently, ‘Like a prayer.’

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Crazy we got like 23” of fascism last week and we might get even more tomorrow. Snow. I mean snow.

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The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning Intrinsically disordered arginine-glycine-rich (RG/RGG) regions are highly abundant in the eukaryotic proteome. Proteins containing these motifs participate in fundamental cellular processes, including nuclear import, transcriptional regulation, biomolecular condensate formation, and apoptosis. Mutations or dysfunction of RG/RGG proteins have been implicated in neurodegenerative diseases and cancer. Although some RG/RGG proteins have been shown to drive condensate formation, localize to membrane-less organelles, interact with nuclear import receptors, or undergo arginine methylation, these properties are not shared uniformly across the proteome. The considerable diversity in RG/RGG motif length and amino acid composition raises the question of which sequence features determine their functional behaviour. To address this, we conducted a systematic bioinformatics and experimental analysis, combining synthetic and natural peptides with studies on the RNA-binding protein FUS as a model system. Our results reveal that the sequence composition of RG/RGG motifs is a key determinant of their capacity for RNA-mediated condensate formation, stress granule recruitment, and transportin-1–mediated chaperoning and nuclear import. These findings provide new insight into the sequence grammar of disordered RG/RGG regions and how it encodes the multifunctionality of these proteins in cellular regulation. ### Competing Interest Statement The authors have declared no competing interest. FWF Austrian Science Fund, https://ror.org/013tf3c58, 10.55776/COE14, 10.55776/P28854, 10.55776/I3792, 10.55776/DOC130 Austrian Research Promotion Agency, https://ror.org/028jc0449, 912192

The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning www.biorxiv.org/content/10.6...

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Dear Catholics who have drifted: The church needs us in the battle for our nation’s soul. Those who have “drifted” but still value the teachings that shaped us need to start being the body of Christ we wish to see.

www.americamagazine.org/faithinfocus...

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Metabolically regulated proteasome supramolecular organization in situ Structural steps along the assembly of proteasome storage granules—membraneless organelles that form in response to metabolic shifts in yeast—are visualized inside cells by cryo-electron tomography. Inactive 26S proteasomes oligomerize into trimers, which assemble into paracrystalline arrays that serve as reservoirs of fully assembled proteasomes under conditions of low energy, ready for reactivation when glucose is restored.

Now online! Metabolically regulated proteasome supramolecular organization in situ

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I guess they are saying we can only exercise one unalienable right at a time now? That the Bill of Rights is a menu, and we can pick only one?

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My sister-in-law's dad died last week, in hospice in the VA hospital in Minneapolis. I just learned Alex Pretti was part of his care team. They shot Alex less than 1/2 mile from my niece's house while doing the same observation work that my niece is doing. These are real people. Step up folks!

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Ugh

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