Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations www.biorxiv.org/content/10.64898/2026.04...

Our thread is now up at @epimechfc.bsky.social 💗

Take a look if you are interested in how a living tissue knows how to sculpt itself!

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social

The shape of things to come: How spheroid geometry guides multicellular orbiting and invasion In research that could shed light on the growth and formation of complex tissue architectures, Brown University engineers show how cells orbit and reconfigure their surroundings to venture outward fro...

Researchers from the @ianywonglab.bsky.social are working toward understanding the dynamics of how tissues develop, as well as how cancer cells break free of tumors to spread around the body, by unpacking how cells interact with each other and their surroundings. www.brown.edu/news/2026-01...

Hilarious Puppies Spin Around Water Bowl! YouTube video by The Pet Collective

not quite the correct geometry, but puppy collective migration seems to have analogies with epithelial spheroids ;)

www.youtube.com/watch?v=Zzg-...

Published online today in Nature Physics - we show how multicellular spheroids round up and orbit, driving a deterministic transition to 3D matrix invasion at predictable locations.

Amazing work from @jiwon-kim.bsky.social, @htjeong.bsky.social and collaborators

www.nature.com/articles/s41...

Interestingly, invasion later initiates near the regions that were originally sharp, where forces become locally concentrated, suggesting a form of shape memory.

What makes you take the first step out of going in circles?
Sometimes, it’s the time spent going in circles itself!

We studied how a ~500-cell spheroid breaks through a stiff matrix to initiate invasion.
The spheroid starts slightly egg-shaped (elongated), but instead of invading right away, it first undergoes a prolonged orbiting phase, during which it becomes nearly spherical. 🧵

Out today in Nature Physics! doi.org/10.1038/s415...
It was highlighted by Brown News: brown.edu/news/2026-01...

Huge thanks to my amazing co-authors Hyuntae
@htjeong.bsky.social and Carles, and deepest gratitude to my mentor Prof. Ian Y. Wong @ianywonglab.bsky.social for leading this journey. 🧵

Hello World!