TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - PubMed Motor neuron hyperexcitability is a broadly observed yet poorly understood feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Nuclear depletion and cytoplasmic aggregation...

Hot off the press from the RTI: TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
buff.ly/X23QYQI #RNA #RNATherapeutics

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

Can I lick it version of the periodic table

This needed to be on chemsky

Angela Messmer-Blust on LinkedIn: #diversityinstem #underrepresentedinscience #rnabiology… I am unbelievably excited and proud to launch the RNA Therapeutic Institute's new Maraganore Early Independence Fellows Program at UMass Chan Medical School…

Hey, senior PhD students working on RNA and moving toward leading independent labs: Apply for the Maraganore Early Independence Fellow program at the UMass Chan RNA Therapeutics Institute and come work with us! www.linkedin.com/posts/angela...

I get excited whenever the carbon intensity of the UK electricity grid is below ~100g of CO2 per kilowatt hour of electricity.

The 2023 average was 162g gCO2/kWh

But just look at this figure - in 2009 it was regularly ~600. We ARE making big changes. Hooray!

Source: tinyurl.com/48dwzz33

Since BlueSky now supports video, here is one of my favourite phone videos. It's a Little Owl that I met at the Hawk Conservancy Trust a year ago. I knew that owls have startling head stabilization, but I'd never been the one generating the instability. The owl didn't seem to mind.

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo Abstract. Glioblastoma multiforme is a universally lethal brain tumor that largely resists current surgical and drug interventions. Despite important advan

In the latest paper from senior PhD student Samantha Sarli, we compare the activity profile of conjugated and unconjugated ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Amphiphilic lipids help drive safe uptake! Online now at NAR: academic.oup.com/nar/article/...

Vote now in STAT Madness 2024 Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Pick your favorites. Help us crown a champ!

Watts lab research was selected to compete in STAT Madness again this year! This time the featured research is our collaboration with Joel Richter's lab, building on their key insight that splice-switching ASOs may be therapeutic for Fragile X. Vote here: www.statnews.com/feature/stat...

A silly ChemDraw diagram of a ficticious polycyclic compound composed entriely of a mixture of lead(II) and lead (IV) atoms. There are two valence errors in the molecule. Can you find them?

Lol I accidentally posted this on Twitter not here. And used the #Chemsky tag. 🧪🤭 A silly

Then, in the CRISPR Journal, working also with Wen Xue's lab, we describe a new fluorescent reporter mouse that's compatible with nuclease and prime editing using multiple PAM variants and Cas enzymes. doi.org/10.1089/cris...

Our two latest genome editing papers published yesterday, both joint with the Sontheimer Lab. In GEN Biotech, we demonstrated the first LNP-mediated in vivo prime editing. Unsurprisingly, pegRNA chemistry was important for efficacy! doi.org/10.1089/genb...

So many emotions. On the one hand, I'm so glad that the publishers of my fifth-grader's math textbook decided that chemistry was the best example of "modeling real life" to put on the cover of their book. But could they not have talked to an actual chemist about the nature of bonds in NaCl first?

This has to be one of the best interviews I've read... contains 100% of recommended daily dose of tenacity, humor, realism, grit, and encouragement. endpts.com/qa-nobel-pri...

Thanks for the invite and shoutout, Mike. Now can somebody get Oded Rechavi to join so we can all have a constant stream of ridiculously good science memes over here?