The essential calcium channel of sperm CatSper is temperature-gated Nature Communications - Here they show that the essential sperm calcium channel CatSper is temperature-gated and reversibly inhibited by spermine. This discovery uncovers a key regulatory mechanism...

Happy to share our latest work on ion channels, published in @natcomms.nature.com. Want to know why testes are external & cool? Nature has evolved a precise system to ensure that sperm are primed for fertilization at the right time. Tour de force work by Dr. Dilip Swain and our team: rdcu.be/eh9W7

congratulations to
@alanbrownhms.bsky.social lab, Rui Zhang lab @ruizhangmt.bsky.social and Qingwei Niu
@qingweiniu.bsky.social!

Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function Progesterone and progestins activate Kir7.1 to control uterine excitability, offering insights for preterm birth therapy.

Thrilled to share that our 4 years of hard work is finally published in Science Advances! 🚀🎉
Huge congratulations to the dream team:
@monikahaoui, Citlalli Vergara, and our fantastic colleagues from the Marc Spehr group www.science.org/doi/10.1126/...