📣Updated ESMO #ClinicalPracticeGuideline on advanced and metastatic #ProstateCancer:
✅ Substantial advances in castration-sensitive & -resistant prostate cancer
✅ Updated algorithms & recommendations reflecting latest clinical data
#ESMOGuidelines Christopher Sweeney

🔗 https://ow.ly/E4ov50Yc8e2

🧬 New preprint out!
Dilara Akhoundova and team identify AURKA as a synthetic lethal vulnerability in FANCA-deficient cancers using complementary CRISPR and drug screens.
🔗 doi.org/10.64898/202...
#PrecisionOncology #SyntheticLethality #FANCA #AURKA #CancerGenomics

Molecular Cancer Research editor Massimo Loda, Franklin W. Huang, Michael C. Haffner, and Irene Paassen discussed "Genomics and Epigenomics" in a plenary session at the AACR Special Conference on Innovations in Prostate Cancer Research and Treatment.
#AACRprostate26 @aacrjournals.bsky.social

Can we help men with hormone-refractory #ProstateCancer through personalized epigenetic therapy? Our new study using patient-derived organoids reveals a targetable weakness in a WNT-driven subtype. @genentech.bsky.social @medfacultyunibe.bsky.social @unibe.ch @pmbern.bsky.social tinyurl.com/2tkn3hwh

New @natmed.nature.com News & Views by @marubin1.bsky.social and Dr. Irene Paassen on why #PrecisionOncology must go beyond genomics. @medfacultyunibe.bsky.social @pmbern.bsky.social
tinyurl.com/2zvdvmy6

📣 Updated ESMO #ClinicalPracticeGuideline on local & locoregional #ProstateCancer:
✅New imaging modalities: Improved diagnosis, staging & risk stratification
✅Updated algorithms: less over-Tx & fewer side-effects
#Oncology #UroOncology #CancerCare #ESMOGuidelines

🔗 https://ow.ly/jwA650XLs1q

Excited to share new preprint on the minor spliceosome in cancer! Targeting U6atac disrupts DNA repair and sensitizes prostate & breast tumors to radiation, cisplatin and PARP inhibitors—even beyond BRCA-mutant . bit.ly/48RnsI5 #DNARepair #ProstateCancer #BreastCancer #U6atac @theaacr.bsky.social

NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...

Congrats to Jia and Michael and team. This has been a major effort and we are learning so much about lineage plasticity www.nature.com/articles/s41....

How Trump’s Medical Research Cuts Would Hit Colleges and Hospitals in Every State Changes to a key funding formula will reduce research grants at hospitals and universities by billions — and may discourage future research.

www.nytimes.com/interactive/...

Opinion | American Science is Under Attack The Trump administration hobbles research and endangers the public health.

I Used to Run the N.I.H. Here’s What Worries Me. www.nytimes.com/2025/02/14/o...