De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion - Nature Genetics The authors deplete the cohesin activator NIPBL during the mitosis-to-G1-phase transition. They observe that structural loop formation is impaired proportionally to loop length, while gene activation ...

Excited to read this! @andersshansen.bsky.social @nicholas-aboreden.bsky.social

www.nature.com/articles/s41...

Why hello! @momedinamunoz.bsky.social

Positron plus JupyterHub logo, with the Posit logo in the corner.

We are thrilled to announce that Positron Server is now available for academic use via JupyterHub!

This gives students a robust #RStats & #Python data science IDE without needing a local install or new infrastructure.

Learn more: positron.posit.co/blog/posts/2...

A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career Brian Donovan had persuaded high school teachers and education researchers that prejudice might be ended by changing how genetics is taught.

A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career. Thank you, @mmolteni.bsky.social for sharing Brian's story. He is a generational talent, indeed, and has inspired my own educational activities deeply. www.statnews.com/2026/04/07/b...

30 seconds of life as a #GilliamFellow, thanks to the 19 cohort members who attended our March Science Meeting alongside ~70 additional HHMI scientists. Potential applicant? Imagine yourself here, and mark Sept. 1 on your calendar to apply!

Some science cuts in Trump's proposed FY27 budget

❌ NIH: -$5B, including all of NIEHS, NIMHD, FIC & NCCIH.
❌ EPA: -4.6B
❌ NSF: -3.8B
❌ NASA Science: -3.4 Billion
❌ NOAA: -1.8B, including the entire Oceanic and Atmospheric Research budget ($605M)
❌ AHRQ: All of it. -$296M, 100%

And there's more.

Here's a big one from NIH. It remains Trump admin policy to

- Cap indirects at 15% (repeatedly rebuffed by courts and Congress)

- Multi-year fund *all* grants. As a reminder, this has the effect of dramatically decreasing the total number of labs and projects supported by the government.

The Lab Bench under Fascism Written by SNAP member Emma Scales

I'm curious what people think about this article I wrote a couple weeks ago for the @snapcoalition.org blog, especially given the news this week that Penn will be required to hand over a list of all Jewish students and faculty to the federal gov't... tinyurl.com/scifascism

Idk what’s worse: the potential for what something could’ve became or the real bummer of what it actually is 😂

Anneliese and Angelique holding their book prototype

A picture of someone reading a book page that features scientists on a ship

The picture of the children’s book on the table.

🚨BIG NEWS! Our book prototype is in

We have been working on this book for over 2 years. This has been such a huge undertaking, and getting to hold the prototype was surreal!

On April 5th we will remove our preorder pricing from the website. Order yours at dreamsofascientist.com

The System That Decides What Science Gets Published Is Breaking Down The peer review system that validates scientific research is trapped in a self-defeating cycle. A new mathematical model shows why—and what comes next.

@forbes.com picking up the recent work by @carlbergstrom.com & Kevin Gross in @plosbiology.org on the future of peer review.

www.forbes.com/sites/johndr...

Had a marvelous time at @simonsfoundation.org Presents featuring @thetransmitter.bsky.social discussing the Future of Neuroscience with Francisco Rivera Rosario, Jie Zheng, and Nancy Padilla-Coreano

Live painting of the discussion by artist Emily Garfield that included my shoes and poop socks 💩

Marissa Scavuzzo — Pershing Square Philanthropies Pershing Square Philanthropies - we bet on innovative leaders solving humanity’s big societal, environmental, and health challenges.

Thrilled to share that the Scavuzzo lab was awarded the 2026 MIND prize to support our fundamental work in understanding how homeostasis is regulated by the gut’s nervous system! See more details here:

pershingsquarephilanthropies.org/prize-winner...

Always great to see other OpEd Project Public Voices Fellows in the wild! @drandrewthaler.bsky.social participated in an awesome panel about the case for optimism in science at the ASC SciTalk conference in Portland, OR!

Panelists from @snapcoalition.bsky.social ‘s mobilizing early career researchers panel today at @sciencetalkorg.bsky.social !!!

#sciencecomm #SNAP

@sneharao.bsky.social @alexlando.bsky.social @emmascales.bsky.social

Excited to share I successfully defended my PhD a couple days ago!!! 🥳 thanks to everyone who’s supported me along the way and for being on this wild ride with me!

As Kobe said: “Job’s not finished!”

A young man with sunglasses is popping out from behind a woman taking a selfie with him at a rally in DC at the Lincoln Memorial.

Zoom screenshot of a young man giving a presentation with the slides in the center showing pictures of him with friends. A party face emoji in the bottom right corner. And he is presenting in the top right corner of the screen.

Beaming with pride after watching @jpflores.rbind.io defend his dissertation yesterday! Now officially Dr. JP Flores. 🍾💃🏼 His passion for science, and equity within science, continues to inspire me. Could not actually imagine a more perfect human to represent science. So glad to know him. ❤️

It was literally the best defense I’ve ever seen! I can only hope to be 1/10 as impactful and productive as DR. @jpflores.rbind.io 🩷
Congratulations! 🎉

Congratulations to GeneBites Senior Editor @jpflores.rbind.io for successfully defending his PhD 🎉! JP’s thesis work focused on how a type of cellular stress impacts the 3D structure of chromatin.

You can read a preprint from his thesis work here: www.biorxiv.org/content/10.6...

#GoodNews #PhD

Such a great day in the lab, having a dissertation watch party for @jpflores.rbind.io, good news for one of our trainees (embargoed), and one of my favorite traditions the annual lab egg hunt! The more you experiment or restock, the more eggs you collect. These nerds already found most 👩‍🔬🧪

I concur, congrats Dr. Flores!! @jpflores.rbind.io

Oh my goodness, congratulations on defending @jpflores.rbind.io !! ✨💪🏽🤩

Poster for his defense

Today i attended one of the most interesting PhD defenses of my career. JP Flores' (@jpflores.rbind.io) combination of scientific achievement & acumen, activities in mentoring, science communication, & advocacy, & creativity in presentation made it virtually unique--look our for him in the future!

You did such a terrific job!! Congratulations 🎉

For my defense tomorrow what if I just rapped, will that suffice

ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF

We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!

In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬

What does this unlock? ⬇️

On NOFOs and funding. grants.nih.gov/news-events/...

NIH grant terminations affected women scientists more than men, study finds A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations

A new paper suggests that grant terminations from the NIH over the past year may have further punctured the so-called "leaky pipeline" because women were more impacted by grant terminations than men

www.statnews.com/2026/03/23/n...

$2.45 billion NIH grant cuts and ~2300 terminated active research grants were DOGE'd in early 2025
Who were most affected?
www.pnas.org/doi/full/10....
Early career and women researchers

When we talk about science or the history of science on this app, can we at least use language that is understandable to people who don’t think about science everyday lol