Overview of RB-TnSeq screens. Top left: Schematic for RB-TnSeq screen experimental set-up. Top middle: Pie chart depicting the number of RB-TnSeq screens completed for each category. Top right: Previously published TnSeq fitness with 27ng/mL isoniazid plotted against BarSeq fitness with 25 ng/mL isoniazid. Dotted line represents linear correlation between statistically significant hits from RB-TnSeq with TnSeq. Bottom left: BarSeq fitness (log2 fold change) for sugI (Rv3331) and sugA (Rv1236). Bottom right: Cofitness data for Rv3220c and Rv1626.

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1

Retraction of: Association between Vitamin D and mortality risk in gout patients This is a retraction of: Xinyu Fang, Jie Zhang, Zixing Zhang, Dongqing Ye. Association between Vitamin D and mortality risk in gout patients, Journal of Pu

Yet another spurious non-linear Mendelian randomization paper has been retracted by a journal academic.oup.com/jpubhealth/a... Kudos to the editors of the Journal of Public Health for following through and retracting spurious publications. What is shocking is that many other journals /cont

Very proud of this and so cool that enhancer-level models can predict the effect of genetic variation. There is so much personal variation in terms of gene regulation in the human brain, it is fantastic to uncover this thanks to technology (whole-genome sequencing and single-cell multiomics) and AI

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution go.nature.com/3GfqrzL
rdcu.be/faNLM

REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems Blumberg et al. present video evidence of twitching during adult sleep in a diverse sample of animals. Adult twitching appears to selectively involve appendages used for active sensing, mirroring thei...

New paper (with lots of cute animal videos!)

Ever watch your dog "run" while asleep and wonder what’s going on in their brain? In Current Bio we suggest that those twitches aren't just leaky dreams—they’re a vital maintenance system for the most precise movements

www.cell.com/current-biol...

🎉Congrats to CeMM PI @bocklab.bsky.social on being awarded an 𝗘𝗣 𝗣𝗲𝗿𝗠𝗲𝗱 grant for personalized treatment in children!

The consortium’s 3-year project, 𝗣𝗵𝗢𝗥𝗘𝗖𝗮𝗦𝗧, focuses on improving the use of high-dose glucocorticoids for acute pediatric immune-mediated diseases.

🔗 Read more: bit.ly/3NPGAzV

We have updated the yeast AlphaFold3 co-folding map. The 15GB docker also has an updated streamlit app that is more responsive and easier to search through if you want to just browse the results. There will be many false positives ! We added known interactions for those wanting to filter.

The International Booker Prize 2026 shortlist: The Nights Are Quiet in Tehran by Shida Bazyar, translated from German by Ruth Martin She Who Remains by Rene Karabash, translated from Bulgarian by Izidora Angel The Director by Daniel Kehlmann, translated from German by Ross Benjamin On Earth As It Is Beneath by Ana Paula Maia, translated from Portuguese by Padma Viswanathan The Witch by Marie NDiaye, translated from French by Jordan Stump Taiwan Travelogue by Yáng Shuāng-zǐ, translated from Mandarin Chinese by Lin King

Presenting the shortlist for the #InternationalBooker2026, supported by Bukhman Philanthropies.

Find out more about the books, authors and translators: thebookerprizes.com/ibp2026

Last chance to join us in person for #EESPhaseSeparation!🧫🧬

Register by 7 April: s.embl.org/ees26-08-bl

This interdisciplinary conference brings together scientists from diverse fields to foster new discoveries and discuss emerging principles in condensate biology.

Big day for proteomics and in good company! Matthias Mann @mannlab.bsky.social @mpibiochem.bsky.social, John Yates and Ruedi Aebersold receive the 2026 GairdnerAwards for transforming how we measure and understand proteins at scale. #SystemsBiology #Proteomics #Gairdner2026

Welcome, Tony Hyman!

EMBL welcomes its new Director General, Tony Hyman, as he takes up the mandate of leading EMBL's six sites.

www.embl.org/news/embl-an...

Congratulations to John R. Yates III, Ruedi Aebersold and Matthias Mann, recipients of the 2026 Canada Gairdner International Award.

Prof. Yates: www.gairdner.org/winner/john-...
Prof. Aebersold: www.gairdner.org/winner/ruedi...
Prof. Mann: www.gairdner.org/winner/matth...

#2026GairdnerAwards

A screenshot of our first conversation with an AI bot over slack

I'm developing an #AI bot name HAL to assist with our research. Here's our first conversation with it over Slack (didn't tell the lab before deploying it) 😂

This is figure 4, which shows graft regeneration of mucosal and submucosal layers.

A paper in Nature Biotechnology presents a tissue-engineered esophageal segment that is functional in minipig, which could have future implications for treating infants born with a ‘long gap’ of the esophagus. go.nature.com/4uLBpS8 #medsky 🧪

Neanderthals survived on a knife’s edge for 350,000 years A pair of studies illuminates these humans’ long, hardscrabble existence

Two new studies of Neanderthal DNA from @massilanilab.bsky.social, @hrougier.bsky.social, @mpi-eva-leipzig.bsky.social and others show our ancient cousins survived for millennia in small, geographically isolated groups. www.science.org/content/arti... @science.org 🧬🏺

protein conformational changes are detected on a proteome-wide scale in live cells by LiP-MS method from @picottilab.bsky.social, which they use to show changes in biomolecular condensates upon arsenite stress ➡️ link.springer.com/article/10.1...

How can the circular economy shape academic events? (part 2) 20 March 2026 Since the circular economy was originally defined based on the Reduce-Reuse-Recycle (3Rs) strategy, the concept has now expanded to include more Rs that minimise waste. Following up…

♻️Part 2 of our guide on how to apply #CircularEconomy principles in your academic events is out. Learn more on additional principles and how to apply them to organise more sustainable academic events:

Consortium partners highlighted in Cell Systems specia… | LiSyM Cancer 2026-02-18 - Prof. Dr. Ursula Klingmüller and Prof. Dr. Julio Saez-Rodriguez as well as his lab member Dr. Ricardo O. Ramirez Flores were interviewed as 'Voice…

We are excited to see that members of our consortium contributed to the 10th-anniversary issue of Cell Systems as 'Voices'. 💻🔬

👏 to Prof. Klingmüller @klingmuelab.bsky.social , Prof. Saez-Rodriguez, Dr. Ramirez Flores @saezlab.bsky.social

📖Read more here:
www.lisym-cancer.org/news/2026-02...

In a meeting yesterday, someone said: "Quick-and-dirty approaches are usually just dirty" – and I thought this was great sentiment.

@erinweisbart.bsky.social & @bethcimini.bsky.social discuss our recent paper on anomaly-based representations for image-based phenotypic profiling. They explain how we encode morphological inter-feature dependencies while maintaining biological interpretability 🔥

📄 Paper: doi.org/10.1016/j.ce...

Stress can cause eczema to flare-up – now we know why Scientists have identified the neurons that worsen the condition during stress.

The network of neurons that fuel eczema symptoms in response to stress have been identified

go.nature.com/4lO7XqI

Unstructured transcription factor interactions enable emergent specificity How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We employed proximity-assisted photoactivation (PAPA), ...

While #DNAbindingdomains & #IntrinsicallyDisorderedRegions individually do not show binding specificity, "ensembles of diverse, unstructured interactions" collectively enable emergent #TranscriptionFactor specificity ➡️ www.science.org/doi/10.1126/...
#generegulation #IDRs #TFspecificity #chromatin

The Czech #ERC_CZ program is the best thing the country has done for research. Czech @erc.europa.eu wannabes who did not get the EU grant receive support from the Czech ministry for 2 to 5 years (depending on the ERC grade (A/B)). It supports research that would otherwise never see the light of day.

BBC Radio 4 - In Our Time, Archaea How a discovery in the 1970s changed the theory of the origin of complex life on earth.

Archaea hit prime time: www.bbc.co.uk/programmes/m...

A bacterial ecocline in Klebsiella pneumoniae may explain its backboned phylogeny Could the shape of phylogenetic trees contain hidden information? This study shows that the "backbone" shape of the phylogenetic tree of the important human pathogen Klebsiella pneumoniae may reveal…

Could the shape of phylogenetic trees contain hidden information? Siqi Liu @campy-bara.bsky.social @danielfalush.bsky.social show that the "backboned" shape of the phylogenetic tree of #Klebsiella pneumoniae may reveal a history of diversifying selection on an unknown trait 🧪

How can we tap into the enormous functional diversity of microbes on this planet?

Join us at EMBL Heidelberg (8–10 Dec 2026) to learn about ongoing efforts to decode gene function and organisation in human gut microbes, and present your science.

Johan Elf, Professor at Uppsala University, former EMBO Young Investigator and EMBO Member since 2022, speaks with us about his work and the importance of EMBO to his #career. 🧪

Continue reading:
www.embo.org/the-embo-communities/emb...

Please repost! There's a few spots left on our Journal Editor Training Workshop (March 20) for PhD students and Post-docs wondering what the next step in their scientific career might be. 👇 Taught by our former journal editors. www.lifescienceeditors.com/workshop3-si...

New preprint on the limits of detecting higher-order interactions in microbial communities.
www.biorxiv.org/content/10.6...
We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.

On my way! I will talk in and chair the first session Thai afternoon, make sure to be there! #gfe2026