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Posts by Zoltan Molnar

Launch of the art and legacy of Santiago Ramon Cajal Wed 29 Apr 2026 3:50 PM - 6:45 PM Life and Mind Building, OX1 3EL Select tickets Share this event Need help? Manage tickets The art and legacy of Santiago Ramon Cajal An exhibition of the fascinating artwork of Cajal. Organised by the Society of Spanish Researchers in the UK (SRUK) Launch: Wednesday 29th April. Talks: Lecture theatre 1, Lower ground floor LaMB 3.50 Welcome from Professor Matthew Rushworth, Head of the Department of Experimental Psychology, University of Oxford 4.00 – 4.30 Dr Patricia Garcia Jareño, Director of Neuroscience Committee, Society of Spanish Researchers in the UK 5.00 – 5.30 – "Cajal, the man, the myth, the scientist... and more" Professor José Ramón Alonso, University of Salamanca 5.30 – 6.00 – "Cajal's interactions with Sherrington"Professor Zoltán Molnár, University of Oxford 6.00 – 6.45 Drinks reception – Ground floor LaMB Location Life and Mind Building, OX1 3EL

Launch of the art and legacy of Santiago Ramon Cajal Wed 29 Apr 2026 3:50 PM - 6:45 PM Life and Mind Building, OX1 3EL Select tickets Share this event Need help? Manage tickets The art and legacy of Santiago Ramon Cajal An exhibition of the fascinating artwork of Cajal. Organised by the Society of Spanish Researchers in the UK (SRUK) Launch: Wednesday 29th April. Talks: Lecture theatre 1, Lower ground floor LaMB 3.50 Welcome from Professor Matthew Rushworth, Head of the Department of Experimental Psychology, University of Oxford 4.00 – 4.30 Dr Patricia Garcia Jareño, Director of Neuroscience Committee, Society of Spanish Researchers in the UK 5.00 – 5.30 – "Cajal, the man, the myth, the scientist... and more" Professor José Ramón Alonso, University of Salamanca 5.30 – 6.00 – "Cajal's interactions with Sherrington"Professor Zoltán Molnár, University of Oxford 6.00 – 6.45 Drinks reception – Ground floor LaMB Location Life and Mind Building, OX1 3EL

Launch of the art and legacy of Santiago Ramon Cajal Wed 29 Apr 2026 3:50 PM - 6:45 PM Life and Mind Building, OX1 3EL Select tickets Share this event Need help? Manage tickets The art and legacy of Santiago Ramon Cajal An exhibition of the fascinating artwork of Cajal. Organised by the Society of Spanish Researchers in the UK (SRUK) Launch: Wednesday 29th April. Talks: Lecture theatre 1, Lower ground floor LaMB 3.50 Welcome from Professor Matthew Rushworth, Head of the Department of Experimental Psychology, University of Oxford 4.00 – 4.30 Dr Patricia Garcia Jareño, Director of Neuroscience Committee, Society of Spanish Researchers in the UK 5.00 – 5.30 – "Cajal, the man, the myth, the scientist... and more" Professor José Ramón Alonso, University of Salamanca 5.30 – 6.00 – "Cajal's interactions with Sherrington"Professor Zoltán Molnár, University of Oxford 6.00 – 6.45 Drinks reception – Ground floor LaMB Location Life and Mind Building, OX1 3EL

Launch of the art and legacy of Santiago Ramon Cajal Wed 29 Apr 2026 3:50 PM - 6:45 PM Life and Mind Building, OX1 3EL Select tickets Share this event Need help? Manage tickets The art and legacy of Santiago Ramon Cajal An exhibition of the fascinating artwork of Cajal. Organised by the Society of Spanish Researchers in the UK (SRUK) Launch: Wednesday 29th April. Talks: Lecture theatre 1, Lower ground floor LaMB 3.50 Welcome from Professor Matthew Rushworth, Head of the Department of Experimental Psychology, University of Oxford 4.00 – 4.30 Dr Patricia Garcia Jareño, Director of Neuroscience Committee, Society of Spanish Researchers in the UK 5.00 – 5.30 – "Cajal, the man, the myth, the scientist... and more" Professor José Ramón Alonso, University of Salamanca 5.30 – 6.00 – "Cajal's interactions with Sherrington"Professor Zoltán Molnár, University of Oxford 6.00 – 6.45 Drinks reception – Ground floor LaMB Location Life and Mind Building, OX1 3EL

ART AND LEGACY OF SANTIAGO RAMON y CAJAL
Organised by the Society of Spanish Researchers in the UK, sponsored by @oxforddpag.bsky.social, @stjohnsox.bsky.social
Launch: Wednesday 29th April from 3:50.
Register here:
www.tickettailor.com/events/oxfor... Lecture theatre 1, Lower ground floor LaMB

4 minutes ago 1 0 0 0
CNS2026 PROGRAMME Cambridge Neuroscience prepared an excellent programme featuring 11 talks from Cambridge neuroscientists, 2 talks from Cambridge NeuroWorks fellows, and 2 plenary lectures from external, guest speakers: Professor Sophie Scott (Institute of Cognitive Neuroscience, University College London), and Professor Zoltán Molnár (Department of Physiology, Anatomy and Genetics, University of Oxford). In addition to the talks, there was a poster session, a trade exhibition, an Early Career Data Blitz session, a drinks reception, and a conference dinner at the beautiful Old Hall at Queens’ College.

CNS2026 PROGRAMME Cambridge Neuroscience prepared an excellent programme featuring 11 talks from Cambridge neuroscientists, 2 talks from Cambridge NeuroWorks fellows, and 2 plenary lectures from external, guest speakers: Professor Sophie Scott (Institute of Cognitive Neuroscience, University College London), and Professor Zoltán Molnár (Department of Physiology, Anatomy and Genetics, University of Oxford). In addition to the talks, there was a poster session, a trade exhibition, an Early Career Data Blitz session, a drinks reception, and a conference dinner at the beautiful Old Hall at Queens’ College.

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36TH CAMBRIDGE NEUROSCIENCE SEMINAR AT QEENS' COLLEGE - CNS2026 “CONNECTIONS AND NETWORKS ACROSS SCALES, SPECIES AND TIME” @camneuro.bsky.social prepared an excellent programme featuring 11 talks from Cambridge, 2 talks from NeuroWorks fellows, and 2 plenary lectures neuroscience.cam.ac.uk/.../.

2 weeks ago 1 0 0 0
Post image One of the first excitatory postsynaptic potential (EPSP) recording from Sir John Eccles’ Laboratory from the University of Otago, Dunedin from 08/02/1951. The EPSP was recorded on a glass plate and was gifted to Professor Zoltán Molnár by Professor Phil Sheard after his seminar at University of Otago in December 2014. Professor Molnár donated the plate to DPAG on the celebrations of Sir John Eccles in 2026. Historic background from Stuart and Brownstone (https://doi.org/10.1016/j.brainres.2011.06.007): Intracellular (IC) recording from vertebrate neurons in the CNS was first achieved by John Eccles [1903–1997] and two younger colleagues (Lawrence Brock [1923–1996]; John Coombs [1917–1993] in Dunedin, NZL (Brock et al., 1951, Brock et al., 1952a, Brock et al., 1952b) and by J. Walter Woodbury [1923-] and Harry Patton [1918–2002] in Seattle, WA, USA (Woodbury and Patton, 1952a, Woodbury and Patton, 1952b). Both groups began their experiments within a few weeks of each other in May–June 1951 and it has become conventional to consider them the co-pioneers of IC-recording in the CNS. This custom probably began after the June 1952 Cold Spring Harbor (NY, USA) Symposium “The Neuron”, where there were presentations from both groups. Woodbury presented the Woodbury and Patton (1952b) results, which included IC recording from spinal myelinated nerve axons, interneurons (INs) and MNs. Woodbury's talk was preceded by that of Eccles (1952), who presented an IC recording of a MN action potential (AP), and a model of the MN's resting potential (RP), excitatory postsynaptic potential (EPSP), and inhibitory postsynaptic potential (IPSP), as based on the results of Brock et al., 1952a, Brock et al., 1952b. This talk and later Eccles' articles exploited the classic results of Alan Hodgkin [1914–1998] and Andrew Huxley [1917–] on the sodium and potassium currents mediating the RP and AP of the giant axons of the squid Loliga (Hodgkin and Huxley, 1952, Hodgkin et al., 1952). At first…

One of the first excitatory postsynaptic potential (EPSP) recording from Sir John Eccles’ Laboratory from the University of Otago, Dunedin from 08/02/1951. The EPSP was recorded on a glass plate and was gifted to Professor Zoltán Molnár by Professor Phil Sheard after his seminar at University of Otago in December 2014. Professor Molnár donated the plate to DPAG on the celebrations of Sir John Eccles in 2026. Historic background from Stuart and Brownstone (https://doi.org/10.1016/j.brainres.2011.06.007): Intracellular (IC) recording from vertebrate neurons in the CNS was first achieved by John Eccles [1903–1997] and two younger colleagues (Lawrence Brock [1923–1996]; John Coombs [1917–1993] in Dunedin, NZL (Brock et al., 1951, Brock et al., 1952a, Brock et al., 1952b) and by J. Walter Woodbury [1923-] and Harry Patton [1918–2002] in Seattle, WA, USA (Woodbury and Patton, 1952a, Woodbury and Patton, 1952b). Both groups began their experiments within a few weeks of each other in May–June 1951 and it has become conventional to consider them the co-pioneers of IC-recording in the CNS. This custom probably began after the June 1952 Cold Spring Harbor (NY, USA) Symposium “The Neuron”, where there were presentations from both groups. Woodbury presented the Woodbury and Patton (1952b) results, which included IC recording from spinal myelinated nerve axons, interneurons (INs) and MNs. Woodbury's talk was preceded by that of Eccles (1952), who presented an IC recording of a MN action potential (AP), and a model of the MN's resting potential (RP), excitatory postsynaptic potential (EPSP), and inhibitory postsynaptic potential (IPSP), as based on the results of Brock et al., 1952a, Brock et al., 1952b. This talk and later Eccles' articles exploited the classic results of Alan Hodgkin [1914–1998] and Andrew Huxley [1917–] on the sodium and potassium currents mediating the RP and AP of the giant axons of the squid Loliga (Hodgkin and Huxley, 1952, Hodgkin et al., 1952). At first…

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A plaque appeared on the wall of our department to remember the work of Sir John Eccles (1903-1997). The first excitatory postsynaptic potential recording was performed in the laboratory of Eccles in the University of Otago, Dunedin and an example was gifted to me by Professor Phil Sheard in 2014.

3 weeks ago 5 0 0 0
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7th Japan-UK Neuroscience Symposium held in Cambridge at Christ’s College. We thank AMED and the MRC for their support in making this meeting possible. Thanks goes to the organisers: Kevin Fox, Gaynor Smith, Jemeen Sreedharan, Kei Cho, Kenji Doya, Mayu Takahashi, Tom Macpherson.

3 weeks ago 5 1 0 0
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Brain Awareness Week at Medical University of Silesia in Katowice, Poland 9-12 March 2026 @BrainAwarenessWeek2026

1 month ago 3 0 0 1

Molnar Lab profile in the latest issue of The Biologist

1 month ago 4 0 0 0
Collaborating teams from @Department of Physiology, Anatomy and Genetics and @Department of Chemistry at University of Oxford engineered 3D microfluidic constructs containing human neuronal progenitor cells (NPCs) cultured either alone or together with mouse astrocytes. The results were striking. Compared to NPCs alone, co-cultures exhibited: Enhanced neuronal maturation Increased cell viability and density Reduced lesion size after implantation Greater axonal outgrowth Improved astrocyte coupling to blood vessels within the graft. High-resolution deconvolved microscopy confirmed the presence of synapses within the implants, while optogenetic experiments demonstrated functional connections between host brain tissue and the transplanted constructs. Both NPC-only and co-culture grafts increased astrocyte size, but co-cultures demonstrated superior structural and functional outcomes overall, underscoring the importance of astrocyte–neuron interactions from the outset. https://advanced.onlinelibrary.wiley.com/.../advs.202507423 The research was done with support from the Oxford Martin School- https://www.oxfordmartin.ox.ac.uk/brain-repair Oxford Martin School More details: https://www.dpag.ox.ac.uk/.../study-reveals-unexpected...

Collaborating teams from @Department of Physiology, Anatomy and Genetics and @Department of Chemistry at University of Oxford engineered 3D microfluidic constructs containing human neuronal progenitor cells (NPCs) cultured either alone or together with mouse astrocytes. The results were striking. Compared to NPCs alone, co-cultures exhibited: Enhanced neuronal maturation Increased cell viability and density Reduced lesion size after implantation Greater axonal outgrowth Improved astrocyte coupling to blood vessels within the graft. High-resolution deconvolved microscopy confirmed the presence of synapses within the implants, while optogenetic experiments demonstrated functional connections between host brain tissue and the transplanted constructs. Both NPC-only and co-culture grafts increased astrocyte size, but co-cultures demonstrated superior structural and functional outcomes overall, underscoring the importance of astrocyte–neuron interactions from the outset. https://advanced.onlinelibrary.wiley.com/.../advs.202507423 The research was done with support from the Oxford Martin School- https://www.oxfordmartin.ox.ac.uk/brain-repair Oxford Martin School More details: https://www.dpag.ox.ac.uk/.../study-reveals-unexpected...

Collaborating teams from @Department of Physiology, Anatomy and Genetics and @Department of Chemistry at University of Oxford engineered 3D microfluidic constructs containing human neuronal progenitor cells (NPCs) cultured either alone or together with mouse astrocytes. The results were striking. Compared to NPCs alone, co-cultures exhibited: Enhanced neuronal maturation Increased cell viability and density Reduced lesion size after implantation Greater axonal outgrowth Improved astrocyte coupling to blood vessels within the graft. High-resolution deconvolved microscopy confirmed the presence of synapses within the implants, while optogenetic experiments demonstrated functional connections between host brain tissue and the transplanted constructs. Both NPC-only and co-culture grafts increased astrocyte size, but co-cultures demonstrated superior structural and functional outcomes overall, underscoring the importance of astrocyte–neuron interactions from the outset. https://advanced.onlinelibrary.wiley.com/.../advs.202507423 The research was done with support from the Oxford Martin School- https://www.oxfordmartin.ox.ac.uk/brain-repair Oxford Martin School More details: https://www.dpag.ox.ac.uk/.../study-reveals-unexpected...

Collaborating teams from @Department of Physiology, Anatomy and Genetics and @Department of Chemistry at University of Oxford engineered 3D microfluidic constructs containing human neuronal progenitor cells (NPCs) cultured either alone or together with mouse astrocytes. The results were striking. Compared to NPCs alone, co-cultures exhibited: Enhanced neuronal maturation Increased cell viability and density Reduced lesion size after implantation Greater axonal outgrowth Improved astrocyte coupling to blood vessels within the graft. High-resolution deconvolved microscopy confirmed the presence of synapses within the implants, while optogenetic experiments demonstrated functional connections between host brain tissue and the transplanted constructs. Both NPC-only and co-culture grafts increased astrocyte size, but co-cultures demonstrated superior structural and functional outcomes overall, underscoring the importance of astrocyte–neuron interactions from the outset. https://advanced.onlinelibrary.wiley.com/.../advs.202507423 The research was done with support from the Oxford Martin School- https://www.oxfordmartin.ox.ac.uk/brain-repair Oxford Martin School More details: https://www.dpag.ox.ac.uk/.../study-reveals-unexpected...

Teams from DPAG and Chemistry at @ox.ac.uk engineered 3D constructs containing human neuronal progenitor cells cultured either alone or together with mouse astrocytes.
Co-cultures performed much better advanced.onlinelibrary.wiley.com/doi/10.1002/...
@martinschool.bsky.social

1 month ago 6 2 0 0
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Brain Growth Patterns Predict 2-Year Neurodevelopment bioengineer.org/brain-growth...
Growth of fetal brain with long-term neurodevelopmental validation provides insights into in utero brain maturation and their predictive relationship with postnatal neurological function. doi.org/10.1038/s414...

1 month ago 5 4 0 0
Berlin and Oxford collaborative researchers funded by Einstein Foundation propose a new circuit theory linking a little-known cortical layer to attention and brain disorders. A long-neglected layer of cells at the very bottom of the cerebral cortex may play a central role in how the brain directs and sustains attention, according to a new paper published in Neuron. In a Perspective article, Matthew Larkum from Humboldt University of Berlin, Tim Zolnik and Britta Eickholt from the Charité – Universitätsmedizin Berlin, and Zoltán Molnár from University of Oxford, propose that layer 6b, a thin band of neurons once thought to be merely a developmental remnant, acts as a powerful controller of attention-related brain activity. Layer 6b is the adult descendant of the subplate, a transient structure that plays a crucial role during early brain development. Although subplate neurons are essential for wiring the cortex in infancy, their surviving counterparts in the adult brain have largely been ignored. The new work argues that this assumption is no longer tenable and suggests that these neurons are ideally positioned to control some of the brain’s most important circuits—those involved in attention, arousal, and awareness. https://doi.org/10.1016/j.neuron.2025.11.024

Berlin and Oxford collaborative researchers funded by Einstein Foundation propose a new circuit theory linking a little-known cortical layer to attention and brain disorders. A long-neglected layer of cells at the very bottom of the cerebral cortex may play a central role in how the brain directs and sustains attention, according to a new paper published in Neuron. In a Perspective article, Matthew Larkum from Humboldt University of Berlin, Tim Zolnik and Britta Eickholt from the Charité – Universitätsmedizin Berlin, and Zoltán Molnár from University of Oxford, propose that layer 6b, a thin band of neurons once thought to be merely a developmental remnant, acts as a powerful controller of attention-related brain activity. Layer 6b is the adult descendant of the subplate, a transient structure that plays a crucial role during early brain development. Although subplate neurons are essential for wiring the cortex in infancy, their surviving counterparts in the adult brain have largely been ignored. The new work argues that this assumption is no longer tenable and suggests that these neurons are ideally positioned to control some of the brain’s most important circuits—those involved in attention, arousal, and awareness. https://doi.org/10.1016/j.neuron.2025.11.024

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A long-neglected layer of cells at the very bottom of the cerebral cortex may directs and sustains attention according to Matthew Larkum, Tim Zolnik and Britta Eickholt from Berlin, and Zoltán Molnár from Oxford @einsteinberlin.bsky.social doi.org/10.1016/j.ne...
www.dpag.ox.ac.uk/news/long-ov...

2 months ago 3 0 0 0
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Orexin/hypocretin knockout impairs mouse visual perception, processing and plasticity, and disrupts development of the cortical subplate
Dr Cornelia Schöne (University of Göttingen)
26 February 2026, 16:00. DPAG
Sherrington Building
Florence Buchanan Lecture Theatre
talks.ox.ac.uk/talks/id/b43...

2 months ago 0 0 0 2
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CORTICAL EVOLUTION CONFERENCE June 15-17, 2026 Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor. https://ventricular.org/corticalevolution26/ Topic: The Cortical Evolution symposium will promote the dissemination of novel ideas and concepts to shed light on evolution of the mammalian cerebral cortex. The goal of this conference is to further our understanding of factors involved in cortical evolution that are relevant for human brain function under normal and pathological conditions. Experts from prestigious research universities in the Americas, Europe, and Africa will present their most recent findings at the meeting. 150 faculty, students, and interested parties are expected. Attendees will have the opportunity to present their work in poster format, and six abstract submissions will be selected for a short oral presentation. The meeting will be organized into topical 5 sessions: Cortical Development Cortical Evolution Evolution of Cellular Types Evolution of Cortex and Behavior Paleoanthropology

CORTICAL EVOLUTION CONFERENCE June 15-17, 2026 Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor. https://ventricular.org/corticalevolution26/ Topic: The Cortical Evolution symposium will promote the dissemination of novel ideas and concepts to shed light on evolution of the mammalian cerebral cortex. The goal of this conference is to further our understanding of factors involved in cortical evolution that are relevant for human brain function under normal and pathological conditions. Experts from prestigious research universities in the Americas, Europe, and Africa will present their most recent findings at the meeting. 150 faculty, students, and interested parties are expected. Attendees will have the opportunity to present their work in poster format, and six abstract submissions will be selected for a short oral presentation. The meeting will be organized into topical 5 sessions: Cortical Development Cortical Evolution Evolution of Cellular Types Evolution of Cortex and Behavior Paleoanthropology

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CORTICAL EVOLUTION CONFERENCE
June 15-17, 2026
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor.
ventricular.org/corticalevol...

2 months ago 10 3 0 1
Title: Physiology of orexin: from nutrient sensing to decision making Orexins are neuropeptides that play a key role in regulating wakefulness, arousal, and motivation. In this talk, Prof. Burdakov will draw on over 20 years of work from his lab to discuss how orexin neurons integrate signals about brain activity and the body’s energy state, and how this information is used to orchestrate real-time arousal and influence fundamental behavioural decisions, such as whether to engage in voluntary exercise. The talk will briefly review key discoveries in the field before focusing on several recent studies that provide new insights into orexin function. Event details: 📅 Date: 19 January 🕓 Time: 16:00-17:00 📍 Location: Biochemistry Department, DCHB, 20-026, Seminar Room 1 The event is open to all and should be of interest to anyone working in or curious about neuroscience, physiology, and decision making.

Title: Physiology of orexin: from nutrient sensing to decision making Orexins are neuropeptides that play a key role in regulating wakefulness, arousal, and motivation. In this talk, Prof. Burdakov will draw on over 20 years of work from his lab to discuss how orexin neurons integrate signals about brain activity and the body’s energy state, and how this information is used to orchestrate real-time arousal and influence fundamental behavioural decisions, such as whether to engage in voluntary exercise. The talk will briefly review key discoveries in the field before focusing on several recent studies that provide new insights into orexin function. Event details: 📅 Date: 19 January 🕓 Time: 16:00-17:00 📍 Location: Biochemistry Department, DCHB, 20-026, Seminar Room 1 The event is open to all and should be of interest to anyone working in or curious about neuroscience, physiology, and decision making.

Title: Physiology of orexin: from nutrient sensing to decision making
📅 Date: 19 January
🕓 Time: 16:00-17:00
📍 Location: Biochemistry Department, DCHB, 20-026, Seminar Room 1
The event is open to all and should be of interest to anyone working in or curious about neuroscience.

3 months ago 4 1 1 0
4 months ago 3 0 0 0
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EVOLUTION AND DEVELOPMENT OF NEURONAL CIRCUITS
@Lauraandreae, @justuskebschull.bsky.social, @tonyzador.bsky.social
Hard copy is out on the collection of articles on how brains are built, diversified, and adapted.
pubmed.ncbi.nlm.nih.gov/41184133/ with KennethKwan pubmed.ncbi.nlm.nih.gov/38167425/

4 months ago 27 2 0 0
Professor László Acsády's Neuroscience Seminar 4pm-5pm, Tuesday 13th January at Florence Buchanan Lecture Theatre Thalamus Research Group; Hungarian Research Network - Institute of Experimental Medicine Szigony st 43., Budapest, Hungary, H-1083 Seminar Title: Axo-spinous communication between the cortex and thalamus Absract: Spines are ubiquitous morpho-functional elements of excitatory synaptic transmission and plasticity in the neocortex. Whether functional spines are also present in the thalamus is currently unclear. Here I demonstrate that layer 5 cortico-thalamic terminals arising from several frontal cortical regions preferentially target functional spines in the thalamus via variable and complex synapses. These axo-spinous L5-thalamic connections are surprisingly powerful, able to selectively recruit a subset of thalamic neuron and are involved in motor learning.

Professor László Acsády's Neuroscience Seminar 4pm-5pm, Tuesday 13th January at Florence Buchanan Lecture Theatre Thalamus Research Group; Hungarian Research Network - Institute of Experimental Medicine Szigony st 43., Budapest, Hungary, H-1083 Seminar Title: Axo-spinous communication between the cortex and thalamus Absract: Spines are ubiquitous morpho-functional elements of excitatory synaptic transmission and plasticity in the neocortex. Whether functional spines are also present in the thalamus is currently unclear. Here I demonstrate that layer 5 cortico-thalamic terminals arising from several frontal cortical regions preferentially target functional spines in the thalamus via variable and complex synapses. These axo-spinous L5-thalamic connections are surprisingly powerful, able to selectively recruit a subset of thalamic neuron and are involved in motor learning.

Professor László Acsády's Neuroscience Seminar 4pm-5pm, Tuesday 13th January at Florence Buchanan Lecture Theatre, DPAG.

Hungarian Research Network - Institute of Experimental Medicine

Axo-spinous communication between the cortex and thalamus

talks.ox.ac.uk/talks/id/73f...

4 months ago 4 1 0 0
Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells on Perinatal Brain Injury—from Pathophysiology to Therapy we show that endogenous neuroserpin alone is insufficient for neuroprotection against hypoxia ischaemia induced damage, but exogenous neuroserpin shows promise as a pharmacological intervention for mild neonatal HIE (https://doi.org/10.3390/cells14231840).

Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells on Perinatal Brain Injury—from Pathophysiology to Therapy we show that endogenous neuroserpin alone is insufficient for neuroprotection against hypoxia ischaemia induced damage, but exogenous neuroserpin shows promise as a pharmacological intervention for mild neonatal HIE (https://doi.org/10.3390/cells14231840).

Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity and mortality. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).

4 months ago 2 1 0 0
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Hungarian Science Club - Sir George Radda FMedSci FRS (1936–2024) - a life in science
By Embassy of Hungary in London
Nov 28 from 4:15pm to 7:30pm GMT
Commemorative Event Honouring Sir George
www.eventbrite.co.uk/e/hungarian-...

5 months ago 0 0 0 0
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First-ever atlas of brain development shows how stem cells turn into neurons
There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!

5 months ago 780 184 11 5
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Sara Bandiera (Balliol) and Florina Szabó (St John's) had their DPhil graduation ceremony last weekend from our laboratory from @Department of Physiology, Anatomy and Genetics. Huge congratulations to both! We thank Medical Research Council UK and Anatomical Society for their respective support.

5 months ago 2 0 1 0
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Professor Makoto SATO - Osaka, Japan, and
Professor Alessandro VERCELLI - Torino, Italy shall give SPECIAL NEUROSCIENCE SEMINARS 11:00-13:00 on Thursday, 4th December 2025
Location: Florence Buchanan Lecture Theatre
Oxtalks links: - talks.ox.ac.uk/.../bf37b319...; talks.ox.ac.uk/.../c069ece9...

5 months ago 4 0 1 0
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SPECIAL NEUROSCIENCE SEMINAR - PROFESSOR ZAAL KOKAIA (Stem Cell Center Lund University Sweden): Reprogrammed neurons and oligodendrocytes for brain repair after stroke
talks.ox.ac.uk/talks/id/342...
Thursday, 11th December at 4pm - Department of Physiology, Anatomy and Genetics, Sherrington Library

6 months ago 7 2 0 0
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Development and function of cortical networks
September 29, 2025
Mainz, Campus of the JGU Mainz, BFZ, Duesbergweg 6, Germany
www.unimedizin-mainz.de/phys.../vera...
This scientific symposium was organised to honor the scientific contributions and achievements of Prof. Heiko J. Luhmann Dr. Luhmann

6 months ago 4 0 0 0
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Jenkinson Developmental Biology Symposium, at the MSTC, on 12 Dec 25.
Registration is now open: please note that registration is mandatory but free of charge. Registration will close on 28 Nov.

6 months ago 6 1 0 0
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Today I gave the opening lecture of the MSc in Neuroscience Course at the brand new Life and Mind Building (LaMB) on History of Neuroscience at Oxford. This was a historic event itself; the very first teaching session in the new building. #Oxneuro #neuroscience

6 months ago 13 0 0 0
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T14 isn’t just a fragment — it’s a signalling peptide shaping brain development & activity. Its dysregulation may help explain Alzheimer’s according to Susan Greenfield. The team is celebrating the publication 👉 doi.org/10.3390/ijms...
Widespread changes in T14 after manipulations of activity.

6 months ago 3 0 0 0
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CORTICAL EVOLUTION - 15-17th June 2026 - Bilbao Spain
Organizers: Verónica Martínez Cerdeño, Fernando García Moreno, Elena Vecino, and Stephen Noctor
Early registration until 1st May 2026
ventricular.org/corticalevol...
@veronicamartinez.bsky.social @phylobrain.bsky.social

6 months ago 15 4 0 1
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Official group photo taken by Professor Kristine Krug

6 months ago 0 0 0 0
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Information Processing in Thalamus and Cortex
Cardiff University, School of Biosciences
19th-20th Sep 2025.
Organised by Kevin Fox in honour of Vincenzo Crunelli & Frank Sengpiel @Cardiff University Biosciences

7 months ago 5 0 1 0
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The search for the mechanisms cortical regulation of sleep continues. Latest collaborative work suggests that part of the answer lies in the cortex.
By switching cortical neurons on and off, we could change how much sleep animals got — and even the quality of that sleep. doi.org/10.1101/2025...

7 months ago 14 4 0 0
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New collaborative research from the Szele Laboratory identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth.
For more details: www.dpag.ox.ac.uk/.../new-rese....
To read the paper: www.science.org/doi/10.1126/...

7 months ago 6 0 0 0