Reveal your fate as a dihaloarene in cross-coupling. Will you retain a halide, or will you lose both of your halides in a double reaction? Roll the ligand and solvent dice to determine—but remember, the rules are different for aryl chlorides and bromides! [Cover art by co-author Matthew Sandin.]

Selectivity for Exhaustive Cross-Coupling of Dihaloarenes Is Affected by the Interplay between the Halide Byproduct, Solvent, and Ligand In dihaloarene cross-couplings, the step(s) that take place after reductive elimination and before the start of the next cycle influence selectivity for monofunctionalization versus difunctionalizatio...

Nate and Matt provide new mechanistic insight into over-arylation in Suzuki cross-couplings, and the surprising differences between dibromo vs. dichloroarenes. Currently free to read as an ACS editor's choice.
pubs.acs.org/doi/10.1021/...

Our C2-selective C—S coupling of 2,4-dichloropyrimidine (work led by Oliver) was highlighted by Synfacts! www.thieme-connect.com/products/ejo...

John Hartwig, chemist: ‘The situation for science in the United States is terrible, these are the steps of authoritarian regimes to take power’ The scientist talks to EL PAÍS about the key advances in the production of new pharmaceuticals

english.elpais.com/science-tech...

The memo on paused grants is also trying to cancel awarded grants (see last paragraph).

C2-Selective Palladium-Catalyzed C–S Cross-Coupling of 2,4-Dihalopyrimidines Under most conditions, 2,4-dihalopyrimidines undergo substitution reactions at C4. Here we report that Pd(II) precatalysts supported by bulky N-heterocyclic carbene ligands uniquely effect C2-selectiv...

Not that we've been huge social media users, but we're migrating here from X. Latest: C2 selective cross-coupling of 2,4-dichloropyrimidine doi.org/10.1021/jacs... (our "holy grail" substrate for inverting site selectivity) and Sharon receives a PECASE (Biden administration) tinyurl.com/yc3de6e6