Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP.

www.cell.com/cell-reports...

Inhibitory normalization of error signals improves learning in neural circuits Normalization is a critical operation in neural circuits. In the brain, there is evidence that normalization is implemented via inhibitory interneurons and allows neural populations to adjust to chang...

How do neural circuits in the brain implement normalization? 🧠

In our new paper, we show that just normalizing sensory input isn't enough. Crucially, we must also normalize the error signals! 🧵👇

Paper: arxiv.org/abs/2603.17676

Are you at #cosyne2026 and looking for a postdoc position? CATNIP = Neural Dynamics Lab is hiring! catniplab.github.io/postdoc-hiri...

The cortex generates invariant dynamic primitives; the cerebellum reconfigures them to drive distinct policies.

Huge congrats to first author Martha Garcia-Garcia for leading this tour de force, and @somnirons.bsky.social & Michal Wojcik for a great collaboration!

www.biorxiv.org/content/10.6...

How heterogeneity shapes dynamics and computation in the brain No two neurons are the same, yet models often treat neural populations as pools of identical and interchangeable elements. Here, Dahmen et al. highlight recent theoretical advances that reveal the imp...

At the Bernstein Conference 2024, Jeremie Lefebvre and I organized a workshop on the computational consequences of neural heterogeneity. Now, slightly more than a year later, we funneled the emerging discussions into a perspective piece: www.cell.com/neuron/fullt...

Building compositional tasks with shared neural subspaces Nature - The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

Thrilled that my paper is out in the @nature.com. We explored how the brain builds complex tasks by compositionally combining simpler sub-task representations. The brain flexibly performs multiple tasks by dynamically reusing neural subspaces for sensory inputs and motor actions

rdcu.be/eRVUk

New paper out at PNAS: www.pnas.org/doi/10.1073/...
Revisiting the high-dimensional geometry of population responses in the visual cortex with @jpillowtime.bsky.social. The review took forever because a reviewer was doubtful our new estimator can infer eigenvalues beyond the rank of the data! (1/6)

We are very excited to announce that our new preprint with Saleh Esteki, @stefanofusi.bsky.social, and @roozbehkiani.bsky.social is now available on biorxiv! www.biorxiv.org/content/10.6.... We investigated how reward context is learned, represented, and updated to bias decisions. Thread 🧵👇! 1/13

A unifying account of replay as context-driven memory reactivation A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing a new account of how and why replay occurs.

Really thrilled that this paper led by @neurozz.bsky.social is now published in its final version in @elife.bsky.social!!

This is a memory-focused (as opposed to RL-focused) account of the detailed characteristics of forward and backward awake and sleep replay!

elifesciences.org/articles/99931

New preprint from the lab! 🚀
We find that hippocampal OLM interneurons provide a circuit-level inhibitory feedback signal that dynamically controls when and where behavioral timescale synaptic plasticity can occur.
Feedback welcome!

Rapid neocortical network modifications via dendritic plateau potential induced plasticity www.biorxiv.org/content/10.1101/2025.11....

Connectivity Structure and Dynamics of Nonlinear Recurrent Neural Networks The structure of brain connectivity predicts collective neural activity, with a small number of connectivity features determining activity dimensionality, linking circuit architecture to network-level...

Now in PRX: Theory linking connectivity structure to collective activity in nonlinear RNNs!
For neuro fans: conn. structure can be invisible in single neurons but shape pop. activity
For low-rank RNN fans: a theory of rank=O(N)
For physics fans: fluctuations around DMFT saddle⇒dimension of activity

Our latest project find shared representations while controlling for confounds is out www.biorxiv.org/content/10.1... Check @s-michelmann.bsky.social 's thread for the executive summary. Code in python and matlab: github.com/s-michelmann... — Now is play time 👨‍💻

Movie-watching evokes ripple-like activity within events and at event boundaries Nature Communications - The neural processes involved in memory formation for realistic experiences remain poorly understood. Here, the authors found that ripple-like activity in the human...

🧠 Paper out!

We investigated how hippocampal and cortical ripples support memory during movie watching. We found that:

🎬 Hippocampal ripples mark event boundaries
🧩 Cortical ripples predict later recall

Ripples may help transform real-life experiences into lasting memories!

rdcu.be/eui9l

Excited to share this project specifying a research direction I think will be particularly fruitful for theory-driven cognitive science that aims to explain natural behavior!

We're calling this direction "Naturalistic Computational Cognitive Science"

7/ In the era of limited funding, our work showcases how to use models to bridge neural and natural behavior data to (1) increase discrimination power over neural models, (2) improve behavioral predictions, and (3) reveal novel bioplausible algorithms for neural computation in natural settings.

6/ Finally, we studied the nonlinear accumulation model of song encoding more closely, revealing previously unknown song patterns driving female slowing, and a neural algorithm for encoding long input sequences that leverages nonlinear adaptation to remember fine temporal patterns for long periods.

5/ Methodologically, our work shows how natural behavior can refine predictions of how neural data generalize beyond their original experimental context AND that modeling hidden neural activity can improve pure natural behavior predictions, even relative to popular black-box deep networks.

4/ This suggests that linear-nonlinear feature detection is not enough, but rather that flies may encode long communication sequences via nonlinear accumulation along multiple dimensions of activity space in a heterogeneous neural population code for song history.

3/ We found that one encoding model, based on multi-dimensional, nonlinear accumulation, allowed us to predict female locomotion much better than a classic linear-nonlinear feature-detection model, also outperforming many other predictors, including several black-box artificial neural networks.

2/ To gain further model discrimination power, we turned to a separate pure-behavior dataset of naturalistic fly courtship. We simulated the female’s neural responses to the male’s song using the encoding models then tried to predict her locomotion from the simulated neural data.

1/ How is the male fruit fly’s complex courtship song encoded in the female fly brain? Calcium imaging of responses to simplified song stimuli suggest neural codes are spread across a population with heterogeneous selectivities and timescales, but multiple encoding models fit the data equally well.

Inferring neural population codes for Drosophila acoustic communication | PNAS Social communication between animals is often mediated by sequences of acoustic signals, sometimes spanning long timescales. How auditory neural ci...

How do we get more neuroscience out of our behavioral data? Excited to share new work with C.A.Baker, M.Murthy and @jpillowtime.bsky.social, where we use natural behavior data to extend predictions from neural recordings about population codes for dynamic social stimuli: tinyurl.com/2d3wwfyf

An intuitive way to derive Shannon's famous entropy formula that you may not have seen before (unless you're a physicist): rkp.science/an-alternati...

🧠🤖 Computational Neuroscience summer school IMBIZO in Cape Town is open for applications again!
 
💻🧬 3 weeks of intense coursework & projects with support from expert tutors and faculty
 
📈Apply until July 1st!

🔗https://imbizo.africa/