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Posts by Matt Towers

Our excursion into the world of hPSC-derived lateral plate mesoderm progenitors, the result of a great collaboration with the lab of @matt-towers.bsky.social. For more details check the thread of @sudeuyulgan.bsky.social below-Sude has been fantastic in leading and driving this work!

5 days ago 7 2 1 0

Brilliant work, Sude—fascinating data and an impressive effort driving this project forward. Congrats!

5 days ago 1 0 0 0
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

1 week ago 262 111 21 10
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...

With the scientific input and experimental brilliance of the @franzelab.bsky.social this work was made possible. www.science.org/doi/10.1126/...

1 week ago 28 8 4 0
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Our bat–mouse limb paper is now on bioRxiv!
🦇www.biorxiv.org/content/10.64898/2026.04...

This was a collaborative effort across the @nadavahituv.bsky.social Nicola Illing, Dorit Hockman, Guy Kelman, Tommy Kaplan labs and my lab at @washugenetics.bsky.social

1 week ago 10 5 1 1

Congrats - so very well deserved and your talk was excellent

3 weeks ago 1 0 0 0
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Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits Molecular biology; Neuroscience; Developmental biology; Omics

Out now in @cp-iscience.bsky.social: we investigate how the peripheral limb architecture can affect the cellular and transcriptional maturation dynamics of spinal cord neurons #plasticity www.cell.com/iscience/ful... congrats and thanks to all co-authors!!! 👏🥳🙏

1 month ago 8 2 1 0

PDRA position still open in my lab for anyone who wants to solve some outstanding questions in limb development. We have a variety of models and approaches (everything from stem cells to chicks and catsharks). Please share!

2 months ago 5 7 0 2
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Research Associate in Developmental Biology at University of Sheffield An opportunity for an academic position as a Research Associate in Developmental Biology is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

A BBSRC-funded PDRA position is available in my lab investigating vertebrate limb development! Please contact me for more details. www.jobs.ac.uk/job/DQH553/r....

2 months ago 1 0 0 2
Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...

It's been quite a year for hypothalamic development. With this heroic analysis of developmental cell lineage, coupled with earlier multimode-based gene regulatory network analysis, the prosomere model looks like it has passed into history.
www.nature.com/articles/s41...

4 months ago 21 5 1 0

Excited to share a fantastic PhD opportunity combining interdisciplinary approaches with me, @alexgfletcher.bsky.social and @rorylcooper.bsky.social sky.social! Please share!

5 months ago 2 2 0 0
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🚨 PhD Projects 🚨

We are advertising two UKRI funded PhD projects at the @sheffielduni.bsky.social. #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology

5 months ago 6 7 0 0

I'm a bit late to the party over here. I'll be advertising a BBSRC-funded postdoc position soon. So if anyone wants to solve some outstanding questions in limb development - please get in touch. We have a variety of models and approaches (everything from stem cells to sharks). towerslab.weebly.com

7 months ago 10 11 0 0