Thank you for the warm welcome! I look forward to this next chapter !

A man in a black jacket with the text "The University of Chicago, Pritzker school of molecular engineering" is standing in a hallway with his arms crossed.

Welcome @drmilossimic.bsky.social to UChicago PME as a Neubauer Family Assistant Professor of Molecular Engineering! Dr. Simic's research focuses on combining cell engineering and synthetic biology to understand and treat brain diseases.

Learn more: pme.uchicago.edu/news/enginee...

Amazing work!

If you’re interested in joining the lab, drop me an email. We’re working on some exciting things which will 🤞🏾hopefully🤞🏾 be supported by a DP2 soon.

Keeping it local: SynNotch-engineered T cells deliver payloads to specific tissues for a diverse range of applications Two teams of researchers working with lead author Dr. Wendell Lim demonstrated the use of synNotch-engineered CD4+ T cells directed towards tissue-specific antigens, triggering the local release of various disease-specific payloads. Reddy et al. utilized this technology to suppress CAR T cell cytotoxicity in on-target/off-tumor tissues and to suppress immune rejection in transplanted organs, while Simic and Watchmaker et al. demonstrated its ability to induce CAR expression only in the brain and to specifically deliver payloads that suppress neuroinflammation.

From suppressing unwanted immunity to inducing immunity where it counts, SynNotch-engineered T cell can carry diverse payloads to specific locations for customized effects in numerous treatments @drmilossimic.bsky.social @pwatchmaker.bsky.social @nishreddy.bsky.social acir.org/weekly-dige...