GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Oh hey, looks like I can upload longer videos here now!
Here’s my most recent one covering the latest findings on ecDNA retention mechanisms from the Chang & Mischel labs.
Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.
More updates on what’s happening to federally funded US science. Roughly the same magic touch Trump has brought to world trade, actually.
Today’s examples are on drug-resistant gonorrhea and vaccine approvals, both of which are going to hell.
Haha, super interesting, that would be a good one to include!
Yes I’ll post here as well!
Great ideas. Would be awesome to do a larger funded effort
I’d love to be able to a video per week, but prob can’t swing it working alone.
I’m planning a video series on the wonders of everyday medicines, from ibuprofen to prostaglandin analogs, to help point out biological innovations taken for granted (subtext: how NIH funding helps everybody)
Looking for help w research and scripting, or just ideas for what to cover & why!
Any scientists want to help with a science communication project? Will reach thousands on TikTok!
Details⬇️
www.nytimes.com/2025/04/03/o...
Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security
Even if that were somehow true, it wouldn’t be comforting to know that a journalist can just scheme their way into White House communications🙄
Gee, I wonder what that study on vaccines and autism will show www.washingtonpost.com/health/2025/...
"Geier and his father, Mark Geier, have published papers claiming vaccines increase the risk of autism, a theory that has been studied for decades and scientifically debunked."
Interesting panelist discussion at #KSTumorMetab25 on communicating science effectively to combat misinformation in this era.
Check out this #WorldView that we, @natrevcancer.bsky.social, published from @juliabauman.bsky.social who posts 60-second TikToks explaining recent papers.
bit.ly/41trLps
Lemme see if I can edit a version down to <60s!
I haven’t seen any good data, but there are probably a ton of bots. Still plenty of accounts that I know to be real humans too!
I know Twitter sucks but it’s a *great* time to try to spread messages about harms to US science to non-academics
Glad to see this post getting some traction, because the Federal Register is the WHOLE ballgame, folks. To drive this point home, a recent EO declares that all posts to FR now must be approved by the White House. www.whitehouse.gov/presidential...
I have had a TON of people asking how they can help...here is what would help us the most right now: SHARE SHARE SHARE SHARE SHARE!
Tell us why you #standupforscience2025! Send flyers to your colleagues and labs! Change your bluesky banner! Tell your professional orgs and departments!
Graphic from United for Medical Research showing that NIH funding produces $2.46 in economic activity for every $1.00 awarded
Graphic from United for Research showing that NIH funding produced over $92B in economic activity in FY 2023
Graphic from United for Research showing that $914M in NIH grants to Florida institutions supported 14,688 jobs and produced $2.78B in economic activity
Cuts to the NIH are a strategy to strangle research universities not “reduce waste”
It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members.
5calls.org
Insanely good news if this holds up.
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
www.science.org/doi/10.1126/...
Took me 3 minutes to call both of my Senators and my representative. Just do it.
Our paper is out!!
TLDR; Cell Painting as a phenotypic readout in whole-genome CRISPR screens is very informative, cheap per cell, & we find some interesting biology!
Dying for a bookmark function on @bsky.app!
How else am I supposed to add to my massive list of unread papers 😰
www.biorxiv.org/content/10.1...
Our study published today on #bioRxiv describe the identification of a deaminase that converts 5mC to T, enabling direct sequencing of the human methylome and genome. This achievement was made possible through a collaborative effort across all departments at #NEB.
Thank you, Ardem!
A template for writing your senator: bsky.app/profile/juli...
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3
experiment.com/programs/pla...
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
