Which way best defines the optimal deep brain stimulation target in #Parkinsons? x-y-z coordinates? sweet spots? fiber tracts? whole-brain networks?
@patriciazvarova.bsky.social has just answered this question: All of them.
New study out now in AoN: onlinelibrary.wiley.com/doi/epdf/10....
New preprint: Revisiting the methodological foundation of lesion network mapping.
doi.org/10.64898/202...
A thread.
A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method.
See below 👇 for our response.
www.biorxiv.org/content/10.6...
Netstim on route to the DBS summit in Würzburg! Looking forward to seeing everybody soon!
For the first time, we characterized the Parkinson's Disease Response Network across space and time, simultaneously. Fantastic work led by @bahnebahners.bsky.social out in BRAIN now 👇👇
Researchers report the identification of "a deep brain stimulation response network that resembles the previously defined MRI network & operates in the high beta band"; Maximal connectivity to this network was associated with optimal DBS outcomes
academic.oup.com/brain/advanc...
🧠 Deep brain stimulation for Parkinson’s disease achieves its best results when a precisely defined brain network operating in the high beta frequency range is targeted. This was shown by a team @andreashorn.org @bahnebahners.bsky.social in both space and time for the first time.👇
uni.koeln/5LYV7
🧠 Die Tiefe Hirnstimulation bei Parkinson zeigt ihre bestmögliche Wirkung, wenn ein präzises Gehirnnetzwerk im Beta-Frequenzbereich (20–35 Hz) stimuliert wird – das zeigt ein Team um @andreashorn.org @bahnebahners.bsky.social jetzt erstmals gleichzeitig räumlich und zeitlich👇
youtu.be/ZrREFuDI-as
This has been an amazing team effort within the RETUNE CRC (sfb-retune.de) together with Roxanne Lofredi, Esther Florin, Andrea Kühn and colleagues from #Düsseldorf and #Berlin! We would like to thank all patients that dedicated their time to participate in this study.
In the future, this cortical signature of #lowfrequency power suppression in the SMA and synchronisation in frontal and cerebellar areas, may serve as a clinically relevant #biomarker to inform DBS programming, targeting strategies, and potentially even non-invasive stimulation approaches.
Using this low-frequency #signature we were able to predict DBS outcome in out of sample data.
Our findings highlight low-frequency modulation across motor and cerebellar regions as a key mechanism of pallidal DBS and re-emphasize dystonia as a #networkdisorder.
In a cohort of 16 patients with cervical dystonia we acquired cortical activity using #MEG ON and OFF pallidal DBS. We found a distinct cortical signature of #lowfrequency power suppression in the supplementary motor area (SMA) and synchronization in frontal and cerebellar areas.
Pallidal DBS is an effective therapy for patients with cervical dystonia. DBS suppresses enhanced #lowfrequency #hypersynchrony in the #basalganglia and modulates sensorimotor and cerebellar #networks in dystonia. However, these anatomical and electrophysiological findings have rarely been linked.
🚨 New research alert: What happens at the cortex during pallidal #DBS in patients with cervical #dystonia? 🧠 ⚡
---> www.researchgate.net/publication/... <-----
Interpreting EEG requires understanding how the skull smears electrical fields as they propagate from the cortex. I made a browser-based simulator for my EEG class to visualize how dipole depth/orientation change the topomap.
dbrang.github.io/EEG-Dipole-D...
Github page: github.com/dbrang/EEG-D...
Can Christmas calm the Parkinson's brain? Feldmann, Neumann colleagues describe in a paper in Movement Disorders how Christmas alters brain signals recorded from deep brain stimulation systems in the setting of Parkinson’s disease. @parkinsondotorg.bsky.social #christmas #xmas
Looking forward to reading this paper (see thread). 👀 #neuroskyence
**Rethinking the centrality of brain areas in understanding functional organization**
New paper I anticipate will become a classic in neuroscience and a must-read for students at all levels.
Understanding brain function beyond brain areas.
#neuroskyence
www.nature.com/articles/s41...
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
Longitudinal Changes in Cortical Response Dynamics with Deep Brain Stimulation to the Subcallosal Cingulate for Treatment-Resistant Depression www.biorxiv.org/content/10.1101/2025.11....
Figure 2. Changes in Motor Diary shows raw data for change in on-time: ST aDBS, DT aDBS, and Motor diary data: ST aDBS, DT aDBS. Graphs show individual participants, observed mean time h/d, asleep, off-time, on-time with TD, and without TD.
Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS. ja.ma/3M2ENGl
New paper out in npj Digital Medicine! Fayed Rassoulou demonstrates how electrophysiology + machine learning can help identify the optimal contact for deep brain stimulation. rdcu.be/eNgG1
schematic of fetal OPM-MEG
📈🧠 We're looking for brains! 🧠📈
Postdoc + PhD positions are available to help pioneer fetal MEG with optically pumped magnetometers, measuring prenatal responses to sound and light to understand how we start making sense of the world even before we're born. 🐣
Please get in touch to hear more!
There's still time to apply! #neurojobs
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
