Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College!
Link: youtu.be/UE-S8R3zd60
Key paper:
@jacs.acspublications.org 2026, 148, 3944-3948.
doi.org/10.1021/jacs...
This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor!
Key paper:
Org. Process Res. Dev. 2024, 28, 8, 3229–3247
doi.org/10.1021/acs....
Join us this week on Synthesis Workshop as Stanislav Melnikov shares his work on the role of quantum tunneling in metal-ligand proton tautomerism!
Link: youtu.be/4hnNuJDdI8Q
Key paper:
@jacs.acspublications.org 2026, 147, 50, 46324–46335.
doi.org/10.1021/jacs...
Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!
Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!!
Link: youtu.be/S2NS3sL6_g0
Key paper:
ACS Catal. 2026, 16, 1, 203–210.
doi.org/10.1021/acsc...
Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!!
Link: youtu.be/-4ggoK4ACUk
Key paper:
J. Am. Chem. Soc. 2025, 147, 13169.
doi.org/10.1021/jacs...
Thanks to Dr. Alicia Wagner for hosting!
Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!!
Link: youtu.be/Gh1qxy7Z7K0
@jacs.acspublications.org 2025, 147, 31, 28098–28106.
doi.org/10.1021/jacs...
Thanks to Kathleen for hosting!
Another fantastic Chemical Science paper being highlighted by @synthesisworkshop.bsky.social!
Check out the video and make sure to read the paper at pubs.rsc.org/en/content/a...!
Once you've seen the episode, head over to synthesis-workshop.com/problem-sets to check out the accompanying problem and solution set!!
Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!!
Link: youtu.be/rhhpewmsRBc
Big thanks to Reem for hosting and editing!
Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!!
Link: youtu.be/EVtEZwUSrbU
@jacs.acspublications.org doi.org/10.1021/jacs...
Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting!
Link: youtu.be/2InU6iFBYFQ
Nature 2025, 644, 96–101.
doi.org/10.1038/s415...
Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!!
Link: youtu.be/BDuyOmrTsqI
Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w
Curious to hear the story behind this paper?
doi.org/10.1021/jacs...
Tune in today on Synthesis Workshop to hear from Dr. Alessia Petti about this exciting advance: youtu.be/optSQ_YY5jE
@jacs.acspublications.org
Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing!
Link: youtu.be/k2nOfYnNk6U
Key paper:
Science 2025, 389(6757), 295-298.
www.science.org/doi/10.1126/...
Thanks to Karim for hosting!!
🔬 You know a young innovator in #organicsynthesis? Great!
Nominate them for the Thieme–IUPAC Prize 2026!
🎖️ €5,000 prize
📩 Deadline: Dec 12, 2025
📤 Send to: marcus.white@thieme.de
More: thieme.de/en/thieme-ch...
@synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social
Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky
Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner!
Link: youtu.be/-pyvGu56Suo
@jacs.acspublications.org 2025, 147, 21121.
We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli!
Link: youtu.be/uyKZgUbB5Fk
Link to our problem sets: synthesis-workshop.com/problem-sets.
Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine!
Link: youtu.be/lzDv8cJRTyQ
Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode!
Link: youtu.be/6XBF6Iqi3vE
Key paper:
doi.org/10.1039/D5SC...
Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!!
Link: youtu.be/6XD7dBUByyQ
Nat Chem. 2025, 17, 1076-1082.
doi.org/10.1038/s415...
This talk also comes with a great hands on tutorial activity designed by the speaker - check it out at synthesis-workshop.com/courses!
Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out!
Link: youtu.be/Hx8kVIsRlO4
Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education!
Link: doi.org/10.1021/acs....
The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry.
Highly recommended if you are in this area and would like to keep up to date with the field:
www.youtube.com/@SynthesisWo...
Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing!
Link: youtu.be/D513hX1gOTg
@chemicalscience.rsc.org
doi.org/10.1039/D5SC...
Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing!
Link: youtu.be/fnFfw9T5DTM
Key paper:
Nat. Chem. 2025, 17, 904–910.
doi.org/10.1038/s415...
Very excited to announce that our recent review has been featured on the cover of Synthesis!!
If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...
Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!!
Link: youtu.be/hbrrRyy0zfU
Key paper:
J. Am. Chem. Soc. 2024, 146, 48, 32919–32924
doi.org/10.1021/jacs...