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If a candidate for office won’t commit to accountability hearings from Day One, don’t vote for them.

1 month ago 2425 612 75 34

SHOULD THE U.S BLOT OUT THE SUN AND USHER IN AN AGE OF ETERNAL DARKNESS? - Gallup 2/20/26-3/5/26

NO - 41%
YES - 38%
UNSURE - 21%

1 month ago 13680 2957 322 186

Five corporations control 90% of the US media market.

Airlines merged from 12 major carriers in 1980 to 4 today.

Four giants control 80% of meat processing.

The evidence of corporate consolidation is everywhere.

It means more power for them and less freedom for you.

1 month ago 11992 4791 597 307
the-unflappablewolf
Who would you trust more?
total stranger in a star trek shirt?
94.5%
total stranger in a star wars shirt?
5.5%
99.421 Stimmen • Verbleibende Zeit: 2 Tage 23 Stunden
thebaconsandwichofregret
No exaggeration, the vote split on this poll is hysterical.

the-unflappablewolf Who would you trust more? total stranger in a star trek shirt? 94.5% total stranger in a star wars shirt? 5.5% 99.421 Stimmen • Verbleibende Zeit: 2 Tage 23 Stunden thebaconsandwichofregret No exaggeration, the vote split on this poll is hysterical.

No but this is entirely correct

1 month ago 5263 1126 99 174

One of the most clarifying and revealing things you can realize about authoritarians is that they are just irrepressibly soft, pathetic, and only comfortable if they are crushing skulls or playing the victim.

1 month ago 341 87 12 2

When you put it like this, a $75 million bribe to Melania and gutting the Washington Post seems like a small price to pay.

1 month ago 10708 3990 254 97
Preview
You Know What? Maybe the Time Is Right for an AOC Presidential Bid She’s only 36, and there’s a good argument that she should run for Senate and bide her time. But she also could be a formidable White House candidate.

AOC describes what has happened in Gaza as a genocide, praises the idea of wealth taxes and has condemned corporate monopolies. Those positions are correct, and they are shared by many Democratic voters.

But not by most of the party’s other 2028 hopefuls. trib.al/tjJdp9t

1 month ago 202 55 12 2
Preview
The hidden ICE blueprint that should horrify every American | Will Bunch An internal Department of Homeland Security document shows how ICE plans to cram thousands of detained human beings inside a Georgia warehouse.

What's more shocking than ICE's plan to cram as many 8,500 humans into massive, soul-crushing warehouses?

Seeing the actual DHS floor plan that echoes slavery ships and history's worst gulags with no rec space but a gun range for guards

My new column on the camps www.inquirer.com/opinion/ice-...

1 month ago 8133 4428 342 379
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Senior day! Stay tuned after the game for the 5 seniors being honored. Caroline, Azzi, Ayanna, Ice, and Serah. I believe it can be streamed on UConn's YouTube or UConn+!

1 month ago 17 1 0 0

I wonder how things might change if there was a law for companies over a certain size, that triggered during layoffs: If they layoff a percentage of the workforce, all their officers and board members have their base and stock compensation permanently reduced by that same percentage.

2 months ago 0 0 0 0
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i have just gotten off a productive call with sauron where i laid out our requests

- nazgul bodycams
- morgul knife must remain sheathed unless suspect is determined to be carrying the one ring
- shelob will be the new point of contact

2 months ago 10219 2931 109 72

Exactly right.

Bovino's leaving? Great, get Noem to resign.

Noem resigns? Great, defund and dismantle ICE.

Go after Stephen Miller too. Bring charges against ICE thugs at the state and local level. Lawsuits. New state laws restricting them.

Every possible angle.

2 months ago 19689 4997 421 187

The biggest risk in this moment is something sociologists call “symbolic compliance.”

That’s when an institution that is violating civil rights gives the public just enough symbolic victories that accountability efforts lose steam before there has been any meaningful change.

2 months ago 20798 8602 265 710

Bovino is just the beginning.
Keep up the fight.
Things are shifting.

2 months ago 938 161 18 4

They don't

2 months ago 0 0 0 0
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AOC: "How rich is it that she is saying showing up to the scene of a protest with a legally owned weapon should be grounds for a person's death, execution at the hands of the state, by the same party and administration that praises Kyle Rittenhouse."

2 months ago 11843 3789 221 179

Wake up. Make breakfast. Do email. Watch a murder. Go to a party for a 5 year old. Laugh with my daughter. See a different angle of that murder. Hear govt officials slander the victim. Play Barbies with my kid. Feed her dinner. Tear up at that victim reading last honors to a vet. Put kid to bed. USA

2 months ago 6990 1420 75 49

I wonder how many Twin Cities veterans had Alex Pretti as a nurse

2 months ago 144 24 2 0
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People think America became the Bad Place after Trump got elected when in reality we elected him because this is the Bad Place.

3 months ago 131 16 1 1
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That does it!

3 months ago 16 2 0 0

Nick Shirley at the US Capitol on January 6th, 2021.

3 months ago 3918 1296 80 46
Highlights
•Severity of Alzheimer's disease (AD) correlates with
NAD+ homeostasis dysregulation
•Preserving brain NAD+ homeostasis prevents AD in mice
• Restoring brain NAD+ homeostasis reverses advanced
AD in mice
• Multiomics across human and mouse AD brain identifies nodes for human AD reversal
Summary
Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases.
In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Abstract
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217.
P7C3-A20 also reverses advanced disease in tau-driven
PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Graphical Abstract (CREDIT: Cell Reports Medicine)

Graphical Abstract (CREDIT: Cell Reports Medicine)

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

3 months ago 1411 361 14 52

GOOD NEWS! Researchers have shown Alzheimer’s disease can be REVERSED- not just prevented. Using a potent neuroprotective compound called P7C3-A20, they found RESTORING balance to a central cellular energy molecule (NAD+) not only PREVENTED disease features but REVERSED them, EVEN at late stages.

3 months ago 11553 4499 220 428
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3 months ago 12066 4357 462 274

Labor gaining just the tiniest amount of power relative to capital a few years back absolutely broke employers' brains

4 months ago 2748 724 2 22