Valérie Borde (@lab-borde) Bsky

Epigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced Training The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47

5 months ago 11 8 0 0

Mei5–Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis Abstract. In budding yeast, Dmc1’s recombinogenic activity is controlled by the meiosis-specific heterodimer Mei5–Sae3. Mei5–Sae3 is required for assembly

Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!

We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.

doi.org/10.1093/nar/...

5 months ago 24 5 0 0

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social

www.science.org/doi/10.1126/...

5 months ago 53 22 6 1

Offer PhD Position Team Lambert | PDF | Genetics | Life Sciences 3-year PhD offer in biology to mechanisms of complex rearrangements of the genome.

A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...

6 months ago 7 8 0 0

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu

@univie.ac.at
@meduniwien.ac.at

6 months ago 45 10 0 3

Protecting double Holliday junctions ensures crossing over during meiosis - Nature Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...

6 months ago 10 8 0 0

#JobOffer

💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social

Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...

7 months ago 0 2 0 0

AI-generated MLH1 small binder improves prime editing efficiency A compact, AI-generated suppressor of DNA mismatch repair can enhance prime editing in vivo and in vitro and can be integrated into a variety of prime editing architectures.

Now online! AI-generated MLH1 small binder improves prime editing efficiency

8 months ago 1 2 1 0

RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossover...

www.biorxiv.org/content/10.1...

8 months ago 8 4 0 0

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complex In mitosis, sister chromatids are preferred repair templates for homologous recombination, whereas in meiosis interhomolog-based repair is promoted. How this switch, which is a defining event in sexua...

Revised version of our original Red1-Hop1-Mek1 story, together with @jweir.bsky.social lab now online @biorxivpreprint.bsky.social

Check it out: www.biorxiv.org/content/10.1...

8 months ago 4 1 0 0

Institut Curie hiring Postdoctoral Position in Mammalian DSB Repair (F/M) in Paris, Île-de-France, France | LinkedIn Posted 8:04:09 PM. About UsInstitut Curie Research CenterInstitut Curie is a major player in the research and fight…See this and similar jobs on LinkedIn.

We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR

8 months ago 4 9 0 0

Recruitment of Mre11 to recombination sites during meiosis The Mre11 nuclease, part of the conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs), is also essential to initiate meiotic recombination in budding yeast by promoting Spo11-induced DSBs. Recruitment of Mre11 to meiotic DSB sites depends on Rec114-Mei4 and Mer2 (RMM) that organize the meiotic DSB machinery by a mechanism involving biomolecular condensation. Here, we explored the role of Mre11 during meiosis and its relationship to RMM condensation. We show that both Mre11 and MRX complexes form DNA-dependent, hexanediol sensitive condensates in vitro. In vivo, Mre11 assembles into DNA damage-dependent foci in vegetative cells and DSB-independent foci in meiotic cells. In vitro condensates and in vivo foci both depend on the C-terminal intrinsically-disordered region (IDR) of Mre11. Importantly, while the Mre11 IDR is dispensable for vegetative DNA repair it is essential during meiosis. The C-terminus of Mre11 forms a short alpha-helix that binds a conserved region of Mer2, and mutating residues within this interface reduces Mre11 foci and DSB formation. Finally, we identified a SUMO-interacting motif within the Mre11 IDR that enhances recruitment of Mre11 during meiosis and facilitates DSB formation. This work identifies multiple mechanisms that collaborate to recruit Mre11 during meiosis to initiate recombination. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, 802525 Fonds National de la Recherche Scientifique, Bruxelles, BE, T.0031.22 Research Council VUB, SRP95, OZR3939 National Institute of Health, US, R01GM074223

We’re happy to present a new preprint from the lab, where we identify new mechanisms that drive the recruitment of Mre11 to recombination sites during meiosis. Work led by star student Priyanka Priyadarshini with help from colleagues and funded by the ERC and FNRS.

www.biorxiv.org/content/10.1...

9 months ago 7 5 1 0

Great work!

9 months ago 1 0 1 0

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

10 months ago 16 11 0 0

Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/

10 months ago 51 59 0 0

Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!

11 months ago 44 11 0 0

#JobOffer

💼 Ingénieur d’étude H/F en biologie moléculaire
📍 Equipe Prioleau
📅 1e septembre 2025
🔗 emploi.cnrs.fr/Offres/CDD/U...

Candidatez avant le 19 mai 2025

11 months ago 1 3 0 0

The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair @kajastelab.bsky.social
Join via Zoom: uniroma1.zoom.us/j/95149984403

11 months ago 5 4 0 2

MAYosis 2025

We have a complete program !

meiosis.cornell.edu/mayosis2025/...

The #Mayosis25 seminar series will open with a tribute to Scott Hawley by @jeffsekelsky.bsky.social.

Congrats to all the selected speakers and we look forward to hearing about your fantastic science !

#Meiosis4ever

1 year ago 7 6 0 2

A must for all DNA repair aficionados!

Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱
✔️ Confirmed top speakers
✔️ Ample opportunities for talks & posters

Don’t miss it: dnarepairmeeting-egmond2026.com

1 year ago 37 19 4 1

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

1 year ago 66 25 2 2

!! Postdoc position available to study homologous recombination in live cells through advanced microscopy analyses in a collaboration between our lab and Angela Taddei's lab, both at @institutcurie.bsky.social in Paris.
Apply to : job-ref-ib8q3lnnxn@emploi.beetween.com

1 year ago 7 11 0 0

📣 Last days to register to the "Physics meet Genome" summer school in beautiful Cargèse, Corsica, June 2nd to 6th 2025. Discover the full program and register by March 8th here: iesc-inscriptions.fr

1 year ago 3 2 0 0

Genome Instability and Human Disease | Institut Curie Advanced Training Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human d...

training.institut-curie.org/courses/geno...

1 year ago 0 1 0 0

Reconstitution of SPO11-dependent double-strand break formation - Nature Reconstitution of recombinantly expressed SPO11–TOP6BL complex recapitulates its DNA cleavage function and together with structural modelling and biochemical experiments, provides insights into the re...

Also see two accompanying papers by the labs of Scott Keeney and Ming-Han Tong reporting similar findings, focusing on the SPO11-TOP6BL complex.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

And here is a nice News&views by Mendez Diaz and Corbett.
www.nature.com/articles/d41...

1 year ago 9 6 0 0

Elvan Böke, Felicity Jones, Francesca Cole and Ofer Rog

Hear hear, our 4 keynote speakers! #MAYosis

May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social

meiosis.cornell.edu/mayosis2025/...

🧵⬇️

1 year ago 20 13 1 0

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish PRDM9 is a DNA-binding protein that helps determine the location of recombination hotspots in many mammals. This study of several species of salmonid fish reveals that PRDM9 function is conserved acro...

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish
journals.plos.org/plosbiology/... interesting findings on PRDM9 polymorphism and hotspot erosion

1 year ago 8 3 0 0

Research Laboratory Technician - Job Opportunities - University of Cambridge Research Laboratory Technician in the Department of Plant Sciences at the University of Cambridge.

We have a research laboratory technician post available in my group - the role will support plant work, and molecular biology, associated with our research on centromeres.
www.jobs.cam.ac.uk/job/47342/

1 year ago 28 28 0 0

MAYosis 2025

Happy new year everyone!

We are please to announce the return of MAYosis in 2025!

Every Wednesday in May at 4pm CET, come hear the latest #meiosis4ever stories!

Abstract sub deadline: March 8 (end of day wherever you are)

meiosis.cornell.edu/mayosis2025/

1 year ago 26 20 1 2

Posts by Valérie Borde