p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease - Nature Aging Salladay-Perez and colleagues explore senescence induction in human and mouse macrophages using multiomic profiling. They characterize a p21+TREM2+ senescent macrophage population, which they function...

p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease
www.nature.com/articles/s43...

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T...

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging
onlinelibrary.wiley.com/doi/abs/10.1...

DNA damage drives a unique, Alzheimer’s disease-relevant senescent state in neurons
www.biorxiv.org/content/10.6...

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, ...

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State
onlinelibrary.wiley.com/doi/full/10....

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics
www.medrxiv.org/content/10.6...

Comparative Oncology: Evolutionary Perspectives, Emerging Discoveries, and Analytical Advances Cancer is an evolutionary inevitability of multicellularity that emerges when cooperative cellular networks collapse into competition for survival and replication. Despite decades of extensive researc...

Comparative Oncology: Evolutionary Perspectives, Emerging Discoveries, and Analytical Advances
www.annualreviews.org/content/jour...

Box A of HMGB1 plasmid reverses the age-related changes in the plasma proteomic profile of perimenopausal monkeys
www.nature.com/articles/s41...

Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza
onlinelibrary.wiley.com/doi/abs/10.1...

Redox rhythms promote fitness by modulating ageing-dependent reprogramming - Nature Metabolism This study reveals that tissue redox rhythms are altered in ageing mice but can be restored through time-restricted application of antioxidants or pro-oxidants, leading to improved physiological funct...

Redox rhythms promote fitness by modulating ageing-dependent reprogramming
www.nature.com/articles/s42...

Psilocybin and human longevity - npj Aging npj Aging - Psilocybin and human longevity

Psilocybin and human longevity
www.nature.com/articles/s41...

Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice - Nature Communications This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potent...

Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
www.nature.com/articles/s41...

Interferon-related inflammaging links epigenetic age acceleration to multimorbidity Liu et al. investigated the relationship between two hallmarks of aging (chronic inflammation and DNA methylation alterations) in four independent cohorts covering different ages and health conditions...

Interferon-related inflammaging links epigenetic age acceleration to multimorbidity
www.cell.com/cell-genomic...

Organelle resilience as a comparative blueprint for longevity - EMBO Molecular Medicine The past decade has defined molecular hallmarks of aging, yet interventions that extend lifespan in short-lived organisms show limited and context-dependent translation to humans. Comparative studies ...

Organelle resilience as a comparative blueprint for longevity
link.springer.com/article/10.1...

An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging
www.nature.com/articles/s41...

Aerobic Fitness and Health-Related Phenotypes: A Two-Stage Phenome-Wide Mendelian Randomization Study
journals.lww.com/acsm-msse/ab...

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome Longevity conferred by reduced IGF-1 signaling requires an intact mitochondrial genome.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
www.science.org/doi/10.1126/...

SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways Developing interventions to delay aging and improve lifespan and healthspan is a critical goal in aging research. Individual geroprotective compounds fail to address the complexity, interconnectedn...

SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways
www.tandfonline.com/doi/full/10....

Young blood
www.science.org/doi/10.1126/...

Frontiers | Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms BackgroundChlorogenic acid (CGA) and taurine are well-known antioxidant compounds reported to reduce skin cellular senescence. However, the biological mechan...

Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms
www.frontiersin.org/journals/mol...

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease A 14-protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, an....

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease
onlinelibrary.wiley.com/doi/full/10....

Therapeutic mitochondria transplants made more efficient with targeting tool A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.

Therapeutic mitochondria transplants made more efficient with targeting tool
www.nature.com/articles/d41...

Translational changes upon aging and dietary restriction in progeroid DNA-repair-deficient mice
agingbiologyjournal.org/Current_Volu...

Adaptive Evolution of FOXO Family Regulating Lifespan Extension and Cancer Resistance in Long‐Lived Species We found that four FOXO genes were under rapidly evolution and positive selection in long-lived species. Our cell experiments revealed that bowhead whale FOXO3 and FOXO4 exhibited tumor-suppressive e...

Adaptive Evolution of FOXO Family Regulating Lifespan Extension and Cancer Resistance in Long-Lived Species
onlinelibrary.wiley.com/doi/abs/10.1...

Chromatin remodeling during brain aging
www.nature.com/articles/s41...

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Cell-type-targeted mitochondrial transplantation rescues cell degeneration
www.nature.com/articles/s41...

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA‐EX‐01 Randomised, Double‐Blind, Placebo‐Controlled Trial Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise (‘cycling hypothesis’). Whether...

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial
onlinelibrary.wiley.com/doi/10.1002/...

Acid–Base Dysregulation Links Aging Metabolism to Frailty Our Metabolic Buffer Model posits that chronic acid load from aging and accumulated stressors depletes total acid buffer reserve, disrupting intersystem crosstalk. This hidden homeostatic erosion dri...

Acid–Base Dysregulation Links Aging Metabolism to Frailty
onlinelibrary.wiley.com/doi/full/10....

Multitissue, multi–time point transcriptomic atlas of aging in mice and rats
www.science.org/doi/10.1126/...

Cell Type‐Specific Expression of p16, p21, and p53 Reveals Age‐Dependent Glial Senescence in the AppNL‐G‐F Mouse Model of Alzheimer's Disease Longitudinal senescence profiling in AppNL-G-F Alzheimer's mice reveals progressive microglial and astrocytic senescence (p16/p21 upregulation, morphological impairment, SA-β-galactosidase activity, ....

Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the AppNL-G-F Mouse Model of Alzheimer's Disease
onlinelibrary.wiley.com/doi/full/10....

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches
www.biorxiv.org/content/10.6...