Metabolite and nutrient regulation of macrophages in obesity and metabolic disease Nature Reviews Immunology, Published online: 15 April 2026; doi:10.1038/s41577-026-01292-4This Review discusses how select metabolites and nutrients act as signalling molecules to regulate the functions of tissue-resident macrophages in obesity and metabolic disease, with effects on disease outcome.

ICYMI: Metabolite and nutrient regulation of macrophages in obesity and metabolic disease

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease - Nature Reviews Immunology This Review discusses how select metabolites and nutrients act as signalling molecules to regulate the functions of tissue-resident macrophages in obesity and metabolic disease, with effects on diseas...

📢NEW Review article by Neil Sprenkle & Evanna Mills @danafarber.bsky.social @harvardmed.bsky.social discusses recent work showing that intermediary metabolites (lactate, succinate, itaconate) and nutrients (glusose, amino acids, free fatty acids) are crucial regulatory signals for macrophages

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease Nature Reviews Immunology, Published online: 15 April 2026; doi:10.1038/s41577-026-01292-4This Review discusses how select metabolites and nutrients act as signalling molecules to regulate the functions of tissue-resident macrophages in obesity and metabolic disease, with effects on disease outcome.

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease

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B Cells & Plasma Cells + B & T Cell Collaboration now streaming. Explore breakthroughs in germinal centers, antibody responses & immune cell interactions

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Cytokine multimerization: when more is more and sometimes less Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

ICYMI: Cytokine multimerization: when more is more and sometimes less

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01288-0This Review provides an integrated overview of Kupffer cell biology, from their embryonic origin and spatial organization to their functional specialization within the liver. It emphasizes how Kupffer cells act as immune sentinels while also shaping metabolic regulation, tissue repair, infection and cancer and discusses how emerging technologies are refining our understanding of their context-dependent roles across physiological and pathological settings.

ICYMI: Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

Great fun to write this review on Kupffer cells with Florent Ginhoux and Paul Kubes, covering origin, diversity and roles in immunity and metabolism, now out in @natrevimmunol.nature.com. Huge credit to Bruna Araujo David, Francesco Andreata and Camille Blériot for driving this work. t.co/rGpmTMRddV

Cytokine receptors do not get old, my friends!

Cytokine multimerization: when more is more and sometimes less Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

Cytokine multimerization: when more is more and sometimes less

ICYMI: Inhibition of NR4A1 potentiates a CD8+ T cell response against active tuberculosis

ICYMI: Haem from stressed mitochondria can drive T cell exhaustion

ICYMI: Ageing tissue fibroblasts support lung inflammaging

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01288-0This Review provides an integrated overview of Kupffer cell biology, from their embryonic origin and spatial organization to their functional specialization within the liver. It emphasizes how Kupffer cells act as immune sentinels while also shaping metabolic regulation, tissue repair, infection and cancer and discusses how emerging technologies are refining our understanding of their context-dependent roles across physiological and pathological settings.

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

Original preprint here: www.biorxiv.org/content/10.6...

Further discussion from @preprintclub.bsky.social here:
www.preprintclub.com/preprint-rev...

Journal Club article from @preprintclub.bsky.social discussing @biorxiv-immuno.bsky.social preprint by @lab-singhal.bsky.social showing that deletion of Nr4a1 in a mouse model of active TB increases the ratio of CD8+ to CD4+ T cells and improves survival

rdcu.be/fci3Y

📢NEW Highlight of @cp-immunity.bsky.social paper by @ucsfpenglab.bsky.social @ucsfaging.bsky.social that outlines a link between fibroblast ageing and inflammaging in 🐁🫁
rdcu.be/fb944

Inhibition of NR4A1 potentiates a CD8+ T cell response against active tuberculosis

Haem from stressed mitochondria can drive T cell exhaustion

Ageing tissue fibroblasts support lung inflammaging

Abortive infection: T cells as early, antibody-independent defenders Nature Reviews Immunology, Published online: 02 April 2026; doi:10.1038/s41577-026-01298-yNeutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is detectable by routine clinical assays, independently of antibodies. Recognizing this capacity reframes correlates of protection and calls for vaccines that harness T cells as early, decisive defenders.

ICYMI: Abortive infection: T cells as early, antibody-independent defenders

Abortive infection: T cells as early, antibody-independent defenders Nature Reviews Immunology, Published online: 02 April 2026; doi:10.1038/s41577-026-01298-yNeutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is detectable by routine clinical assays, independently of antibodies. Recognizing this capacity reframes correlates of protection and calls for vaccines that harness T cells as early, decisive defenders.

Abortive infection: T cells as early, antibody-independent defenders

🎉April issue now online🎉
www.nature.com/nri/volumes/...

Cover image inspired by a Review of neutrophil nuclear segmentation
www.nature.com/articles/s41...

Also featuring the Consensus Statement on 'Guidelines for T cell nomenclature'
www.nature.com/articles/s41...

ICYMI: NK cell mechanosensing through CD16a

ICYMI: Skin stem cell niches reprogramme resident immune cells into homeostatic partners

Three talks. One panel. One question. 🧬
How do regulatory T cells keep the system in balance?

Sakaguchi. Miyara. van der Veeken. Alissafi.
Plus live Q&A and panel.

🗓️ April 29 | 3:00 pm CEST
🔗 https://loom.ly/SY4rF60

#DOI2026 #ImmunologyWithoutBorders

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Two new @preprintclub.bsky.social Journal Clubs out now, discussing @biorxiv-immuno.bsky.social preprints on: •CD16a as a mechanosensitive receptor
•Immune cell programming by skin stem cell niches