What does aging-associated brain lipofuscin consist of?
Could this accumulating mass impair neuronal function and contribute to neuronal aging?
In situ identified proteins from human brain lipofuscin by proteomics
Among top hits PPT1 linked to genetic childhood lipofuscinoses
shorturl.at/ih7Cn
"This work establishes a versatile platform for concurrent biosynthesis and diversification of psychoactive indolethylamines, paving the way for their production in plants."
www.science.org/doi/10.1126/...
Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy
www.nature.com/articles/s41...
Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy
www.nature.com/articles/s41...
"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype"
www.nature.com/articles/s41...
"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype"
www.nature.com/articles/s41...
Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology
cell.com/cell-reports...
Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology
cell.com/cell-reports...
Alzforum: Phospho-Tau Might Take Down Viruses - But how does HSV-1 elicit increased tau phosphorylation and aggregation?
alzforum.org/news/researc...
Potent novel anti-Herpes Simplex Virus 1 drug:
• Effective in human brain organoids
• Targeting macrophage migration inhibitory factor (MIF)
• Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo
www.cell.com/cell-reports...
Potent novel anti-Herpes Simplex Virus 1 drug:
• Effective in human brain organoids
• Targeting macrophage migration inhibitory factor (MIF)
• Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo
www.cell.com/cell-reports...
Prof. Dr. Carsten Korth (rechts) und Dr. Andreas Müller-Schiffmann (links) vom Institut für Neuropathologie (UKD) in ihrem Labor. - Copyright HHU
Veröffentlichung in Cell Reports Medicine: Besseres Verständnis von Alzheimer-Risikofaktoren
Forschenden der Heinrich-Heine-Universität Düsseldorf (HHU) und des Universitätsklinikums Düsseldorf (UKD) ist es erstmals gelungen nachzuweisen, ...
weiterlesen
Online now: Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology
Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK
Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK
"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology"
Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...
"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology"
Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks: Cell www.cell.com/cell/fulltex...
"These results highlight the increasing synchronization between gut microbiota rhythmicity and sleep-wake cycles during infancy,..."
www.nature.com/articles/s41...
New today in @Nature: your visual cortex contains touch-based body maps. bit.ly/VisualBodyMaps
Your brain transforms what you see into first-person, body-referenced codes: A previously unknown bridge between vision and touch.
"we present an in situ proteome analysis of age-associated human brain lipofuscin that ... reveals PPT1 protein as one major constituent ...It remains to be demonstrated whether PPT1's ... sequestration to lipofuscin leads to ... functional impairments"
onlinelibrary.wiley.com/doi/10.1111/...
@sfnjournals.bsky.social , @hhu.de , @ckorth.bsky.social , @socforneuroecon.bsky.social , @sfn.org , @decisionneurop.bsky.social
#neuroscience #schizophrenia #sociallearning #social #socialneuroscience #neuroeconomics
doi.org/10.1523/JNEU...
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
