New onset auto-immune disease is a COVID special treat....

Thank you for the valuable insight 🙏🏻

Apparently.... Indefinitely 🤷🏻‍♂️

Run the Maths...

You can only contract Influenza A if a given strain - once

Cövid is readily available for repeated infections 3-4 times/year

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Berkeley's final crowdfunder for Trial By Error has almost reached 150 donations and 25% of the goal!!!

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Cognitive impairment in long-COVID: frequency, trajectories and risk factors in a cohort study from Italy - Neurological Sciences Neurological Sciences - Data on cognitive impairment in patients with Long-COVID remain controversial. The study analyzed in patients followed for Long-COVID the frequency and risk factors for...

🧠 Daily Feed of Brain Damage 🧠

link.springer.com/article/10.1...

Frontiers | Endothelial and cardiac dysfunction in long COVID With cardiovascular symptoms is associated with imbalance in the ADMA–DDAH–NOx pathway BackgroundPost-acute sequelae of COVID-19 (PASC) commonly feature lingering symptoms of persistent cardiovascular pathology, yet the mechanisms remain incomp...

www.frontiersin.org/journals/car...

😆😆😆🎯

🧠 Daily Feed of Brain Damage 🧠

Things that don't improve and will get worse with repeated infections ☠️

@atranscendedman.bsky.social 🙏🏻

www.nature.com/articles/s41...

Acute SARS-CoV-2 viral load and systemic inflammation are associated with neuropsychiatric and musculoskeletal symptoms in long COVID Background Long after recovery from acute-COVID illness, many patients show persistent multi-organ dysfunction consistent with Long COVID. Biochemical profile and measurements of inflammatory markers ...

🧠 Daily Feed of Brain Damage 🧠

journals.plos.org/plosone/arti...

The endless corruption of journals really escalated when they moved from being the prestigious portal where science went to be debated and refined...

Now??

Merely profit driven massive publicly listed companies

Money corrupts... Big money destroys all is owns

Awwww Shucks 🫢🙏🏻

I've been posting my Daily Feed of Brain Damage for 4 years, from memory. It's been a constant for many on Twitter.

There are days when people are on holiday, politics is overwhelming etc...

But, suffice to say, my EndNote library is sitting at about 2,000 + papers on the🧠

Essentially, the TSPO is a marker of auto-immune activation. It's increase in these older cohorts would suggest a component of their brain injury is auto-immune inflammation.

The suggestion of note if that the Neuropsychiatric disorders may be responsive to immune-Rx's

🧠 Daily Feed of Brain Damage 🧠

My unbroken run continues

doi.org/10.1016/j.jn...

😊👍🏻

Understanding the long-term neurological effects of SARS-CoV-2 infection - Nature Reviews Neurology Post-COVID-19 condition (PCC), also known as long COVID, is a heterogeneous condition marked by persistent symptoms following acute SARS-CoV-2 infection. This Review summarizes the spectrum of neurolo...

🧠 Daily Feed of Brain Damage 🧠

doi.org/10.1038/s415...

🙏🏻🙏🏻 Jonathan

Nomenclature has long been an issue

Frontiers | Two-year trajectory of cognitive decline and neurological sequelae in COVID-19 survivors with acute neurological symptoms IntroductionThe COVID-19 pandemic caused by SARS-CoV-2 has profound implications for global public health. It significantly affects the nervous system and co...

🧠 Daily Feed of Brain Damage 🧠

Insomnia is consequent to direct invasion of the Pre-frontal cortex. Reduced Slow Wave Sleep impairs Glymphatic Drainage

Not your friend☠️‼️

doi.org/10.3389/fnag...

Immune dysregulation in prolonged Long-COVID: lymphocytes emerge as key mediators of persistent inflammation, exhaustion and cytotoxicity - Journal of Translational Medicine Background Long-COVID affects at least 10% of COVID-19 survivors, displaying debilitating symptoms across multiple organ systems. Despite the widespread prevalence, Long-COVID aetiology remains poorly understood, but emerging evidence points to immune dysregulation as a potential mechanism involved in its development or persistence. Methods This study presents a unique analysis of the peripheral blood mononuclear cell transcriptomic profile of COVID-19 and Long-COVID patients at single-cell resolution. We reconstructed the cell state and intercellular communication using differentially expressed gene profiling and ligand–receptor interaction analyses. Results Our results reveal altered T and natural killer cell subset proportions, diminished proliferating lymphocyte and B cell signalling capacity, and the expression of exhaustion and cytotoxicity associated genes 1.5–2 years post-infection, suggesting incomplete immune recovery. Distinct interferon responses in these cell populations at the acute phase for patients who go on to develop Long-COVID indicate early disease mediator potential. Conclusions Collectively, these findings provide insight into the immune processes underlying the progression of COVID-19 into a chronic Long-COVID state. The observed changes in immune cell subsets at the acute phase of the infection may be predictive of Long-COVID progression and could be useful in understanding disease aetiology while the observed long-term effects are crucial to developing therapeutic and diagnostic tools.

COVID is immune damaging. What's concerning is the duration of dysregulation

doi.org/10.1186/s129...

Thank you for translating 😎🙏🏻

Frontiers | Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance IntroductionChanges to brain perfusion may be contributing to long-term cognitive dysfunction following COVID-19 infection. Lower brain perfusion beyond the ...

🧠 Daily Feed of Brain Damage 🧠

Hypoperfusion

doi.org/10.3389/fnhu...

Pentagon Pete will be under the bus before this even gets heard.

His mouth is bigger than Donnie's and that simply won't do in this Administration

File this under...

Fuck we are a shitful Species 🤬🤬

doi.org/10.1016/j.bb...

I would prefer EMDR to a Cøvid infection... But, hey 🤷🏻‍♂️, that's just me

Yeah 😂😂😂💪🏻

Yeah...

Ugly AS ☠️

COVID-19 and cardiovascular outcomes in patients with pre-existing hypertension - Journal of Human Hypertension Journal of Human Hypertension - COVID-19 and cardiovascular outcomes in patients with pre-existing hypertension

Cøvid is remarkably adept at finding whatever was hurting you prior... And pressing on that bruise

👇🏻👇🏻👇🏻

www.nature.com/articles/s41...

Nothing stays in one population...

With substantial falls in testing on PCR, only the more severe cases may be swabbed. Many older people may not be registered when tested on RA tests.

Kids are more likely to be swabbed for the purposes of excluding other pathogens.

The data is based upon very small numbers