Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer Early-onset colorectal cancer (EO-CRC) occurring in individuals under age 50 is rapidly increasing globally, while the incidence of late-onset colorec…

A new @carolinejohnson.bsky.social #johnsonlab study compares tumor metabolomes in early- vs late-onset #colorectalcancer, revealing distinct metabolic + immune features that could inform more tailored treatment strategies.
sciencedirect.com/science/arti...

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pi....

Look at this amazing work on #Senescence Cell Induction Methods with Diverse Metabolic Reprogramming & Underpinning Serine/Taurine Reductive #Metabolic Phenotype by the legends Domenica Berardi, @carolinejohnson.bsky.social, @nikrat.bsky.social in Aging Cell onlinelibrary.wiley.com/doi/10.1111/...

Faculty Research Awards Showcase YSPH Strengths in Science Whether developing a new test for malaria, exposing health risks associated with climate change, or highlighting the impact of stigma on LGBTQ+ population

Whether developing a new test for malaria, exposing health risks of climate change, or highlighting the impact of stigma on LGBTQ+ population well-being, our faculty advanced science in impactful ways over the past year.

Their efforts were recognized with the annual faculty research awards ⬇️

Dr. Oladimeji Aladelokun presents new findings #AACR25 highlighting a reduced tumor burden in females only in response to exogenous asparagine supplementation during colorectal tumor growth.
@yalesph.bsky.social

Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex - Human Genomics Background Sex-related differences in colorectal (CRC) incidence and mortality are well-documented. However, the impact of sex on metabolic pathways that drive cancer growth is not well understood. Hi...

Congratulations to Dr. Oladimeji Aladelokun, Postdoctoral Associate in our lab, on being named a finalist for the 2024 Office of Health Equity Research (OHER) Award for Yale Research Excellence! So very well deserved!!

Please see link to his research: humgenomics.biomedcentral.com/articles/10....