looking at some gorgeous starburst cells — congrats @yessicasantana.bsky.social !

👍

sadly, i can’t make it this year….

I see you - and I work on the retina!

Incredible study - is there anything this lab can’t do? congrats to the team!

Normal neuro-vascular maps of the macular inner-retina. Top half clinical imaging: Topographic analyses from 96 normal eyes for OCT thickness (Trinh et al., 2022b) and 57 normal eyes for OCTA signal (Trinh et al., 2021a), with exclusion of any retinal macular/optic nerve pathology. Common locations of the optic nerve head and retinal blood vessels were excluded from OCT scans (Burke et al., 2024a, 2024b; Tong et al., 2020; Trinh et al., 2020, 2021b, 2022b). OCT layers are depicted on the left using a standardised thickness scale (darker green = greater thickness), while OCTA slabs are depicted on the right using a standardised OCTA signal (darker red = greater OCTA signal). Vascular slab approximations were adapted from Campbell et al. (Campbell et al., 2017). For reference, the RPE-BM (drusen layer) is shown using OCT thickness, and the choriocapillaris is shown using OCTA signal. Bottom half histological imaging: Resin embedded, 100 nm serial section of mid-peripheral retina of aged, normal human eye (87 year old male) with amino acid immunolabelling of GABA, glycine, and glutamate mapped to the red, green, and blue colour channels, respectively, and rod opsin labelling indicated in yellow. The section illustrates the laminar organisation of the inner- and outer-retina for cross-reference with the OCT layers above and the distinct neurochemical signatures of neurons in these layers. White scale bar 100 μm. RNFL, retinal nerve fibre layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS/OS, photoreceptor inner- and outer-segments; RPE-BM, retinal pigment epithelium to Bruch's membrane.

New publication: Inner-Retinal Changes In AMD: Evidence, Mechanisms, and Future Perspectives.
A fun project with Matt Trinh, Michael Kalloniatis, myself, Glenn Yiu, Enrico Borrelli, and Lisa Nivison-Smith
bryanwjones.com/2026/03/inne...

Bogus autism treatments suck the oxygen out of the room for treatments that can help families. I’m running for Congress to help save democracy, but I’m also going to use democracy to save science.

An enteric neuron ionotropic receptor regulates salt stress resistance - Nature The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related...

Here's the link to the online OA version:

www.nature.com/articles/s41...

New paper out in @cp-neuron.bsky.social 🎉

What determines contextual modulation in V1? Why does the visual surround sometimes facilitate and sometimes suppress a neuron's response to its preferred stimulus?

mad neuroscientists marching in Berkeley

A neuroscientist in the House!….let’s help make this happen. Thank you @samwang.bsky.social for stepping up

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A big thank you to everyone in the Feller lab and the UC Berkeley MCB/Neuroscience community for their feedback on this project. Special shoutout to Feller lab contributors @gliangel.bsky.social, Ben, Matt, Aileen, and Kiara!

We are excited about this result because it suggests Müller glia could be engaging with growing vessels through an activity-independent, parallel developmental program to provide instructive cues. (10/11)

Müller glia show calcium transients in their stalks, lateral processes, and endfeet, but each compartment behaves differently. Stalks were the most correlated with neural activity, but endfeet were weakly correlated, even with increased neurotransmitter spillover (9/11)

We combined two-photon calcium imaging of Müller glia and voltage-clamp recordings from retinal ganglion cells (RGCs) to measure signaling at Müller glia endfeet during development. Is endfoot calcium signaling driven by spontaneous neural activity? (8/11)

Using sparse labeling, we visualized Müller glia (green) during the early stages of angiogenesis. At the angiogenic front, endothelial tip cells (purple) directly contact Müller glia lateral processes! Could these contacts be providing instructive cues for angiogenesis? (7/11)

In deeper vascular layers, blood vessels are surrounded by a thick plexus Müller glia, even at the earliest stages of their growth. Subsets of glial lateral processes form specialized contacts (called “endfeet”) with the vasculature.(6/11)

Is spontaneous neural activity required for angiogenesis? We looked in mice with perturbed retinal waves and saw that angiogenesis proceeds normally. Could Müller glia be influencing vasculature development, independent of neural activity? (5/11)

First, we mapped vascular development across angiogenesis. We stained vessels and quantified density as a function of distance from the optic nerve and saw that density was remarkably consistent during outgrowth (4/11)

Astrocytes guide the growth of the superficial vasculature layer, but do not travel to the inner parts of the retina. As Müller glia extend throughout the width of the retina, we wanted to investigate if these glial cells play a role in inner retina angiogenesis.(3/11)

In mammals with thick retinas, inner retina vasculature stratifies into 3 distinct layers. In mice, the development of these layers occurs postnatally. This occurs alongside spontaneous neural activity (“retinal waves”) and dynamic Müller glia maturation. (2/11)

Posting on behalf of (soon-to-be) Dr. Samira Monshietehadi (not on Bluesky) -- "I’m very excited to announce that my PhD thesis project is now a preprint! www.biorxiv.org/content/10.6.... We show how Müller glia engage with growing retina vasculature in an activity-independent manner."(1/11)

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wonderful news!!

Bay Area friends, I'm coming out this weekend! Meet up with me in the Stanford/Silicon Valley area. We have a great event on Saturday. Please come!

RSVP for details:
secure.actblue.com/donate/wange...

In a hotly contested primary in NJ-12, help send a scientist and democracy reformer to Congress!

New preprint from the group on the evolution of retinal cell types. Check the summary by Dario @dariotommasini.bsky.social !

gorgrous day to @standupforscience.bsky.social in SF with Stanford Colleague @wormsense.bsky.social and @ucberkeleyofficial.bsky.social #neuroscience and #mcb colleagues.

Go @annaintegrated.bsky.social !!