Love the first sentence of the significance statement! 👍

A cell fate specification and transition mechanism for human foveolar cone subtype patterning | PNAS In the central region of the human retina, the high-acuity foveola is notable for its dense packing of green (M) and red (L) cones and absence of b...

I'm excited to share our PNAS paper from 1st author Kasia Hussey. We study how the foveola, the high acuity region of the retina, is patterned by RA and TH. We were surprised to find that cone subtypes appear to convert fates. Our studies are important for AMD sufferers. www.pnas.org/doi/10.1073/...

Thanks for the invite! It was great to see you all and learn about your department!

We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.

Happy Halloween from the Meyer Lab! 🎃

Excited to share the latest paper from our lab! Excellent work from Cátia Gomes and Kang-Chieh Huang!

Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell–based microfluidic platforms

May 2025. The people on the Segway tour must be the violent gangs and bloodthirsty criminals we are warned about 🤣

Shelby Hetzer, a postdoc in the @meyerlab.bsky.social , crushing it at the Stark Neurosciences Institute Summer Science Symposium!

too bad your path didn't take you through Indianapolis - best of luck with the move!

Another exciting pre-print from the lab! This time featuring the work of MSTP student Kaylee Tutrow, we explored the functional consequences of the CX3CR1-V249I polymorphism in human stem cell-derived microglia models!

www.biorxiv.org/content/10.1...

A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to irreversible vision loss. Increasing evidence implicat...

Happy to share a new pre-print from the lab. Here we use human stem cell models to explore how microglia modulate retinal ganglion cells in developmental and neuroinflammation, both directly and in concert with astrocytes. Amazing work from PhD student Jade Harkin!

www.biorxiv.org/content/10.1...

Lab photo (or at least most of the lab) during a tour of the new Medical Education and Research Building at IU School of Medicine. Can’t wait to move in later this year!

a cartoon of a woman sitting in front of a computer ALT: a cartoon of a woman sitting in front of a computer

waiting on IRG scores to post.....🫣

Bill Gates: I lost my father to Alzheimer’s. But I’m more optimistic than ever about fighting the disease Bill Gates writes: “We are on the cusp of turning the tide against dementia — which makes this an especially bad time to pull back on research.”

Highly impactful read on the state of Alzheimer's research, and neurodegeneration more broadly. And quite a shout out to Indiana University and the neuroscience programs here at the Stark Neurosciences Research Institute!

www.statnews.com/2025/06/17/b...

Lab lunch to commemorate Kate’s time with the group as she departs for medical school.

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species The World Health Organization has linked alcohol consumption to over 200 diseases including neurodegenerative diseases. A dysfunctional blood–brain ba…

Check out the latest research from the lab of #IUStemCell member Scott Canfield! In this study, they demonstrate that excessive alcohol levels impair the integrity of the blood-brain barrier in human stem cell-derived models, contributing to the onset or worsening of neurological disorders.

In this strange times, attending #ARVO2025 has been a breath of fresh air. Inspired by the work, energized by the community and just so so grateful for the chance to spend time with friends and colleagues ❤

New preprint from the lab! Check it out!

Finally, Kiersten Peña presents a poster on the development of a retinal organoid model for studies of ocular phenotypes associated with CHARGE Syndrome, A0061

Carson Prosser presents her work on the induction of an aged phenotype in stem cell-derived retinal ganglion cells, A0053

Also check out Kate Cowger, presenting a comparison of stem cell-derived retinal ganglion cells across three commonly used differentiation methods, A0063

Next is Shelby Hetzer presenting on an in vitro model of eye to brain connectivity, A0058

5 posters from the Meyer Lab today! Come check out some exciting work from the lab! First is Shruti Patil presenting work on NF1 model of optic pathway gliomas, A0075

Thanks Anna! Quite a compliment coming from you!

Check out two awesome posters from the lab this afternoon at 2:00 at #ARVO2025! Cátia Gomes will present work on complement activation in astrocytes for glaucoma (A0433) and Aaron Baker will present work exploring stem cell models of APBB2 gene variant in glaucoma (A0434)

Annual gathering of our #AudaciousGoalsInitiative team at @arvoinfo.bsky.social. Lots of exciting work together, and more great ideas to come! #ARVO2025

After meeting get-together with the ARPA-H project crew!

Looking forward to moving into our new, expanded lab space!!!

@meyerlab.bsky.social at the #ARVO2025 Sunday social

Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids Guo and colleagues developed vascular network-inspired diffusible (VID) scaffolds for engineering midbrain organoids, providing a versatile technology for organoid development and therapeutic innovati...

Congratulations to Feng Guo and his lab for their recent exciting publication in @cp-cellstemcell.bsky.social where they pursue the use of diffusible scaffolds for functional maturation of midbrain organoids! Very cool work!