#GliaPapers #GliaSpecial2025 REVIEW

Stanislaw Majewski, …, @benclarkeuk.bsky.social, Rickie Patani
www.crick.ac.uk/research/fin...

Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB - Molecular Neurodegeneration Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, ...

Excited to share our new paper!Using iPSC-microglia with VCP mutations, we uncovered immune & lysosomal dysfunction. Secretome transfer revealed JAK-STAT activation in neurons & astrocytes. A big team effort over many years!

molecularneurodegeneration.biomedcentral.com/articles/10....

This is great thanks! Would love to be added