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Posts by Khalspi

Header for my new publication (linked)

Header for my new publication (linked)

It’s published… the first manuscript from the Rich Lab is officially typeset and published!!!

What an absolutely surreal moment… that I’m going to try my best to enjoy while awaiting the results of a study section from last week 😅😅😅

journals.plos.org/ploscompbiol...

4 hours ago 10 1 0 0

New work w/ Zach Kelso and @madeleinecsnyder.bsky.social
www.biorxiv.org/content/10.6...
Our negative results on classical conditioning in planarian flatworms. This was surprising, given the long history of work (including sensational findings of memory transfer and retention through decapitation).

7 hours ago 65 27 5 4

One of the things that has always bothered me about TV. Everything is fundamentally filtered through how a TV writer sees the world. It's a very...*particular* sort of worldview — only a very particular sort of person lives in LA and gets work as a TV writer — and once you see it you can't unsee it.

12 hours ago 15 2 3 0

When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased.

3 days ago 36 3 1 0
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Medial temporal lobe encodes cognitive maps of real-world social networks | PNAS Humans routinely solve social problems by navigating densely interconnected networks—gossiping strategically, brokering across cliques, and coordin...

Now out in PNAS with @jaeyoungson.bsky.social, Alice Xia, @apaxon.bsky.social & @orielf.bsky.social. Medial temporal lobe encodes predictive representations of people's real-world social networks which afford them key advantages in social navigation. www.pnas.org/doi/10.1073/... 🧵

6 days ago 55 20 1 2

Looking forward to presenting our work on the origin and flexibility of reward signals at the @arc-mpib.bsky.social next week!

4 days ago 5 1 0 0
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

1 week ago 262 111 21 10

Amazing study and the coolest results (from my point of view!) is that LC norepinephrine neurons projecting to the frontal cortex encode reward prediction error

1 week ago 15 5 0 0
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Delivering tactile stimuli via mobile browsers: A method for remote multisensory research - Behavior Research Methods Online methods are becoming an essential part of the behavioral scientist’s toolkit. While the remote presentation of visual and auditory stimuli has been shown to be reasonably accurate (Bridges et a...

Do you want to use vibration stimuli in remote research studies? 👀 📳🤳🏼

Our latest paper in Behaviour Research Methods might be of interest to you!

Coauthors include: @kalvinroberts.bsky.social @peircej.bsky.social @multisensorylab.bsky.social

link.springer.com/article/10.3...

1 week ago 19 10 1 0

Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...

Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

1 week ago 239 113 6 16

what's your ai strategy?
what's your quantum computing strategy?
what's your ww3 strategy?
what's your collapse of consensus reality strategy?
what's your restructuring of global supply chains strategy?
what's your pedophile billionaire cabal blackmail ring strategy?

1 week ago 657 109 29 38
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"The cerebellar circuitry may be uniquely poised to learn the probability of events in the world and internalize these as prior knowledge." pubmed.ncbi.nlm.nih.gov/41946969/ The Bayesian little brain?

1 week ago 14 2 0 0
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PoM: A Linear-Time Replacement for Attention with the Polynomial Mixer This paper introduces the Polynomial Mixer (PoM), a novel token mixing mechanism with linear complexity that serves as a drop-in replacement for self-attention. PoM aggregates input tokens into a comp...

🚨 arxiv.org/abs/2604.06129

PoM: A Linear-Time Replacement for Attention with the Polynomial Mixer

This paper is the result of doing a lab-wide hackathon on an idea I've had for some time. Probably the paper with the highest number of authors I've ever done.

It's a CVPR Findings 26.

Thread 🧵👇

1 week ago 58 18 4 2

This wonderful collaboration, led by @idoba.bsky.social and co-supervised by me and @shaharnitzan.bsky.social, is now published in Translational Psychiatry (www.nature.com/articles/s41...).

We find that autistic individuals show more accurate and less biased credit assignment during an RL paradigm.

2 weeks ago 6 2 1 0
Video

new proof of concept: ATProtoCall! video calling over atproto with just static files and no dedicated signaling or streaming infrastructure.

2 weeks ago 257 34 11 11
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‘The Brain, In Theory,’ an excerpt In his new book, Brette pushes back against theories that describe the brain as a “biological computer.” In this excerpt from Chapter 4, he challenges equating brain evolution with programming…

"The Brain, In Theory" is out today!

A short excerpt in The Transmitter @thetransmitter.bsky.social

www.thetransmitter.org/theoretical-...

2 weeks ago 69 26 3 0
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I like how Anthropic is just obliquely releasing their work on recursive self-improvement.

2 weeks ago 156 17 8 11
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Israel says it will keep control over part of southern Lebanon after war with Hezbollah ends Defence Minister Israel Katz also says houses in Lebanese villages near the Israeli border will be demolished.

If racism was a country: www.bbc.co.uk/news/article...
“In addition, the return of more than 600,000 residents of southern Lebanon who evacuated northward will be completely prohibited south of the Litani until the safety and security of northern (Israeli) residents are ensured”

2 weeks ago 8 2 0 0

I liked this thread: bsky.app/profile/gui....

It highlights that the power of the platform is in the API access it exposes and controls.

The great thing about ATproto is that most of the data is freely accessible: posts, likes, follows. 🧵

2 weeks ago 32 3 1 0

But behind the scenes, Israeli officials have conveyed a more targeted message.

In private calls to local leaders across southern Lebanon, Israeli military officials have assured several Christian and Druse communities that they could remain in the evacuation zone. They have pressed them, however, to force out any Lebanese from neighboring Shiite Muslim communities who have sought refuge among them as Israeli bombardment flatten Shiite towns, according to local Christian, Druse and Shiite leaders who spoke to The New York Times. The Shiites make up the majority of southern Lebanon.

But behind the scenes, Israeli officials have conveyed a more targeted message. In private calls to local leaders across southern Lebanon, Israeli military officials have assured several Christian and Druse communities that they could remain in the evacuation zone. They have pressed them, however, to force out any Lebanese from neighboring Shiite Muslim communities who have sought refuge among them as Israeli bombardment flatten Shiite towns, according to local Christian, Druse and Shiite leaders who spoke to The New York Times. The Shiites make up the majority of southern Lebanon.

So what this describes is ethnic cleansing www.nytimes.com/2026/04/01/w...

2 weeks ago 5705 2166 89 88
The alt text for this image is available upon reasonable request.

The alt text for this image is available upon reasonable request.

Majestic, well done @rickcarlsson.bsky.social

2 weeks ago 67 27 2 0

Stoked this is finally out! We ask: how can we simulate the brain from the bottom up? It's not sufficient to grab the connectome and wire it up in silico! We need 1) ultrastructure 2) (causal) calibration data 3) functional data. Then we can build a simulation compiler. 1/

3 weeks ago 19 5 1 0
Plots showing that within population fragments genetic diversity plummets following habitat fragmentation.

Plots showing that within population fragments genetic diversity plummets following habitat fragmentation.

What is happening is that locally the species is actually becoming significantly _less_ genetically diverse, but the fragmentation disconnects parts of the species, which slowly diverge from each other.

The species-wide diversity masks the plummeting local diversity. Again, this is BAD.

3 weeks ago 3 2 1 0

This is BAD. If we monitor the genetic diversity of a species, we might be convinced that it's doing okay, when in fact it may continue to lose genetic diversity for a long time even without losing any more of its habitat!

3 weeks ago 2 2 1 0

Delighted to share our latest preprint: Julie Zhu identifies a surprising reason why the genetic architecture of brain-related traits is so different than other traits. Check it out!

3 weeks ago 28 9 0 0
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3 weeks ago 9676 2555 13 118

The hardest part of science is posing the right question, not answering it.

3 weeks ago 242 52 4 2

New work from our lab spearheaded by the amazing @kaixiangzhuang.bsky.social offering a fresh look at the big five personality traits.

3 weeks ago 5 1 0 0

Super excited to see the first paper from my PhD out! 🐭 Very satisfying to get to build an interpretable model of how the brain does a thing. A nice palette cleanser in the current sea of LLMs and deep ML.

3 weeks ago 26 10 1 0
chart showing how scientists tested chatbot sycophancy

chart showing how scientists tested chatbot sycophancy

What I love about this paper on chatbot sycophancy is how they did their experiment, by comparing chatbot responses and human responses to Am I The Asshole threads on Reddit.
www.science.org/doi/10.1126/...

3 weeks ago 24 5 0 0