Sleep matters for joint health!

In our new paper led by Dr Liz Rowlands, we studied sleep habits of 500,000 people. Osteoarthritis risk was highest with <6 hours of nightly sleep and significantly increased by shift work.
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Osteoarthritis as a systemic disease Nature Reviews Rheumatology - Emerging evidence suggests a paradigm shift in viewing osteoarthritis (OA) as a systemic, bidirectional disease. This Review examines the current data supporting this...

Honored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.

Thanks for all your participation in the session!

Thanks so much @ardemp.bskyverified.social!

Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice - Arthritis Research & Therapy Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the under...

Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....

Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...

Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!

Chronotherapy in RA Treatment: Tantalizing but Understudied Research is evaluating chronotherapy to target drugs to reduce morning stiffness and flares in rheumatoid arthritis, but it has a long way to go before it reaches the clinic.

Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied
www.medscape.com/viewarticle/...

9 Federally Funded Scientific Breakthroughs That Changed Everything

We don’t always know what questions will change the world.

But public science has a way of answering them anyway.

Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility.

www.nytimes.com/2025/05/16/s...

Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....

Your research on Ion Channel Regulation might be the next watershed discovery! Join FASEB for the latest findings at #ICRSRC with keynote speaker @farsh-g.bsky.social
and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp

Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....

Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!

🚨 Big updates!
✅ Successfully defended my PhD thesis:
“Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration”
✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine!
Grateful & excited !

Please widely share these 3 new advocacy letter templates with your colleagues.

@lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social

Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!

www.science.org/doi/full/10....

Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab

Ion channel research can have major consequences for cancer and cardiovascular disease treatments. Join FASEB at #ICRSRC for the latest findings with keynote speaker @farsh-g.bsky.social and organizer @roseedixon.bsky.social. Check out the full program and save your space: buff.ly/d213NE1

Congrats ‪@kelseyhcollins.bsky.social‬ on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!

put me in, coach...

Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics.

April 24 | 4:00 PM ET
Register Here: lnkd.in/eTrzEem6

Joint the AOC at myaocconnect.com!

Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!

Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!

Congrats Hope!

A Definitive Guide to Racquet Sports, From Tennis to Pickleball to Padel There are so many racquet sports with varying levels of difficulty, benefits, and #vibes. Find the one that's right for you here.

www.menshealth.com/health/a6375...

The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛

AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇

takeaction.io/aimbe/suppor...

Engineered stem cells automatically deliver arthritis drugs at prescribed times of day “This technology has the potential to change a lot of lives.

Engineered stem cells automatically deliver arthritis drugs at prescribed times of day
apnews.com/press-releas...
www.nature.com/articles/s41...

Thanks Amro!

Thanks Duygu!

Great collaboration with Erik Herzog and Qing Jun Meng labs!