1/4💻Séminaire PACRI : modélisation de la bactérie Clostridioides difficile 💡
Étudiante en M2 de Bio-ingénierie à l’Université libre de Bruxelles, une formation à l’interface entre les sciences du vivant et l’ingénierie, Lolita Antunes s’est spécialisée en bio-informatique depuis son master.
Photo taken at St Pancras train station in London
A little trip back to London today to think about age, gender and antimicrobial resistance 🤓
Super interesting to hear about how biological and social factors interact to change AMR burden... And yet how little data we have to disentangle that!
Thanks @gmknght.bsky.social for the workshop!
1- Le laboratoire MESuRS recrute un stagiaire pour une durée de 5 à 6 mois dans l’objectif d’analyser des données issues d’un large système français de surveillance de l’antibiorésistance en ville et en Ehpad pour mieux comprendre les phénomènes de multirésistance chez K. pneumoniae.
New workshop alert 🚨 We are organising a Symposium and Workshop on Socioeconomic and Ethnic Inequalities in Infectious Disease Transmission at the LSHTM on 22–24 April 2026. Sounds like something you're working on? Find out more and apply before 21st Jan 2026 iddconf.org/lshtm-sympos...
Mais l'évaluation des chercheurs par les publications reste (malheureusement) "pratique" pour l'aspect quantitatif... Tant qu'il n'y a pas d'évaluation quantitative d'autres types de productions (communications, activités de médiation...), dur de voir comment les comités vont se passer des publis !
EVI-led #PrIMAVeRa_AMR project has published an article on BioProcess International on the use of monoclonal antibodies to tackle #AMR, & how PrIMAVeRa's open-access digital platform can support evidence-based public health decisions.
📃 www.bioprocessintl.com/monoclonal-a...
@ihieurope.bsky.social
🔴 Our last paper just published in The Lancet @thelancetendo.bsky.social with an amazing international team ! @ongsantdiabte.bsky.social
"Task shifting and task sharing in paediatric type 1 diabetes care: a global survey" #T1D #type1diabetes
www.thelancet.com/journals/lan...
Le séminaire PACRI de novembre a présenté l’évolution de projets en cours dans l’unité PACRI.
Pour MESuRS, @quentinlclrc.bsky.social a apporté des précisions sur les travaux réalisés pour «AMR Data Challenge 2025», avec Laura Temime, Chloé Aupépin et Eve Rahbé. www.youtube.com/watch?v=UHkg...
A LinkedIn post with an AI-generated image of an antibiogram, containing unreadable text
One of the great science communication mysteries to me: *why* is there so much AI-generated content on LinkedIn?
Not sure an AI-generated antibiogram like this is useful to convey the importance of AMR to a wide audience... 🥲
Chloé Aupépin next to her poster on the the impact of vaccines on AMR at the AC modélisation annual meeting
And finally Chloé Aupépin presented a poster on the impact of bacterial vaccines on #AMR ! 🦠
Using modelling, we can identify which bacteria and vaccine characteristics influence most the impact of these vaccines on reducing infections 📉
Another day another presentation, this time by Elise Hodbert on patient-transfer networks within and between hospitals! 🏥
Networks are mostly used for surveillance, to identify the facilities to monitor to detect outbreaks early. Possibly under-used for infectious disease transmission modelling...?
Two months ago, I also had the chance to present my simulation study at the #ICPIC2025 conference in Geneva 🫕
Aurélie Maurin presenting her work in front of a audience at the AC Modélisation annual meeting
Day 2 of the AC Modélisation annual meeting at @pasteur.fr 💻 🦠
Several presentations by PhD students of the @mesurs-cnam.bsky.social lab, first one by Aurélie Maurin on vaccination dynamics against S pneumoniae - work directly informing vaccine strategy in France!
And now I'm very much convinced that the best way to talk about AI in research is to advocate for responsible use... Of course it has limits, like any tool, but it also has its usefulness!
The key is explaining the balance between the two sides... Like we do with any other tool
Photo of a lecture hall with the speaker showing a slide on the risk of hallucinations by LLMs, in the context of a discussion on the use of LLMs in scientific writing
Day 1 of the AC modélisation annual meeting at @pasteur.fr 💻
First day is "early-career researchers day", with a round table on careers in academia in France, and now a discussion on the use of AI in scientific writing! Good to think about why we shouldn't list ChatGPT as an author on papers...
Excited to say that we have a PhD project out on our age-sex research - looking at combinations of #AMR. With the fabulous @jodi-lindsay.bsky.social and Lanre Edun! Do get in touch for more information!
mrc-lid.lshtm.ac.uk/2026-27-proj...
« AMR Data Challenge 2025 »
MESuRS remporte le prix Innovation avec Chloé Aupépin, Quentin Leclerc (@quentinlclrc.bsky.social) et Laura Temime.
Une compétition internationale organisée par Vivli où l’objectif est de proposer de nouvelles analyses pour mieux comprendre l’antibiorésistance
Overall, we identified optimal conditions to maximize quarantine hospital strategy benefits in an epidemic situation. We propose several recommendations to implement such a strategy when facing a virus with characteristics similar than SARS-CoV-2.
Thanks again to all co-authors for this work! 😁
7/7
Of course, deciding whether or not to implement this strategy depends on other factors.
However, importantly, other studies did not find a difference in the mental health of HCWs between quarantine and non-quarantine hospitals, suggesting this would not be a barrier to implementation.
6/7
However, we find that this strategy only has a strong impact if:
- epidemic control is high in the community
- symptomatic HCWs comply well with self-isolation
Otherwise, increased transmission in the community counters the benefit of reduced nosocomial risk.
5/7
Epidemic curves showing that the quarantine hospital strategy leads to a small epidemic peak and attack rate in both HCWs and non-HCWs.
In a medium-sized city with two hospitals, we estimate that converting one of the two hospitals to a "quarantine hospital" can decrease the attack rate in HCWs by more than 10 percentage points, and the attack rate in non-HCWs by more than 20pp.
4/7
As shown in other work (eg bmcinfectdis.biomedcentral.com/articles/10....), hospital-acquired infections can significantly drive overall COVID-19 dynamics, hence the importance of reducing them.
In our work, we show that the quarantine hospital strategy can be effective for this purpose.
3/7
Mathematical model diagram. The model captures movements of individuals (non-HCWs and HCWs) between the community, quarantine and usual hospitals.
Quarantine hospitals were fully dedicated to the care of COVID-19 infected patients & staffed by healthcare workers staying continuously inside for 1-2 week-long shifts.
To understand their impact compared to keeping usual hospital organisation, we built a model coupling hospitals & community 💻
2/7
An strategy generalised in Egypt to control nosocomial risk during the COVID-19 pandemic was the use of "quarantine hospitals" 🏥
In this new PLOS Comp Bio paper, we show how this strategy impacts epidemic dynamics 📉
w/ Théo Pinettes @kvn-jean.bsky.social Laura Temime @mesurs-cnam.bsky.social
1/7
Screenshot of the website for project proposal submission with the error "This site can't be reached"
What trying to submit a project proposal 24h before the deadline looks like:
(mais apparemment c'est la même chose chaque année pour les projets ANR, je découvre juste 🤓)
And no, I will never stop reminding people that these are burden *estimates* and not data, this is most certainly a hill I will die on 🙃
A great example to highlight the problem of publication metrics, as it shows that the line between "good" and "bad" science is blurry...
In AMR research, we all frequently refer to the IHME burden estimates, so this is worth keeping in mind 👇
Mais au fait, qu'est ce qu'on fait au labo @mesurs-cnam.bsky.social ? 🦠😷💻
Il y a 2 semaines, j'ai présenté le labo en 3min lors du séminaire de rentrée du Cnam. Pour la Fête de la Science, je me suis dit que ça serait utile d'avoir cette intro en vidéo, et voilà ce que ça a donné 👇
Haha merci, je transmettrai à mon pote caché dans le public qui a joué au photographe pour l'occasion 😂
