What does it take to truly understand #cancer in all of its complexity?
Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️
www.cell.com/cell/fulltex...
A new feature @science.org on the clusters of cells that enhance the spread of cancer, and what can be done to break them up
www.science.org/content/arti...
The brain is a garden where neurons ("butterflies") thrive on on immune "nectar", shaping plasticity, protection, and repair
When exposed to inflammatory signals, astrocytes can display MHC class II complexes needed for antigen presentation
Astrocytes, once viewed as passive support cells in the brain, can become cells that regulate the immune system, Emory researchers led by @sloanlab.bsky.social have demonstrated. The results are published in Neuron -- @cp-neuron.bsky.social www.cell.com/neuron/abstr... 1/3
Nature research paper: Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
go.nature.com/4t2SpS5
Aging rewires tumor biology by activating the integrated stress response to suppress primary tumor proliferation and enhance metastatic competence
Whether you inherit your X chromosomes from your mother or from both parents could impact brain aging and cognition: www.simonsfoundation.org/2025/02/05/new-research-... #BrainAwarenessWeek #neuroscience #science #BrainWeek
We're back from the @theaacr.bsky.social Special Conference on Early Onset Cancers! A major highlight was the update from Mark Foundation-Waxman Foundation grantee Ashani Weeraratna on her research into how the aging tumor immune microenvironment influences tumor progression. #AACRearlyonset25
Are you using the right tumor micro environment model? Cancer is a disease of aging @sitcancer.bsky.social #SITC25 great session at the annual meeting on the aged immune system and the tumor micro environment moderated by Drs DA and A Weeraratna.
How to disconnect therapy-resistant tumor networks in glioblastoma?
In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...
Review 🚨
Easwaran&Weeraratna outline how #ageing leads to epigenetic alterations in the #TME, enhancing clonal expansion of mutations and ultimately increasing cancer risk.
📖 👇
In the United States, cases of early-onset cancer are on the rise. Featured in a recent #AACRBlog on early-onset cancer, this Cancer Discovery article explores how changes in risk factor prevalence and/or improvements in detection could affect risk across an age range. Read more: buff.ly/NLssp4H
Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse
go.nature.com/41iIdJR
Biochemistry and Molecular Biology PhD Defense Seminar. Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment. Alexis Carey. PhD Candidate, Weeraratna Lab, Biochemistry and Molecular Biology Department. Cellular and Molecular Medicine Program.
Congratulations Dr. Alexis Carey! Alexis Carey is in the Cellular & Molecular Medicine program and successfully defended her PhD today. In today's seminar she shared her about work in the Weeraratna Lab on “Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment”
Listen to BDP @ashi-w.bsky.social discuss her work in #melanoma research on the Kimmel Cancer Center podcast, Cancer Matters.
hopkinskimmel.libsyn.com/cancer-matte...
"No tumor is an island" and "oncology recapitulates embryology" - a fascinating conversation with the incredible @ashi-w.bsky.social at the CSHL symposium on aging.
We talk about how cancer rates increase with age, the T(I!)ME, and the role of Wnt signaling www.youtube.com/watch?v=_Txf...
This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...
We explore the utility of an immunohistochemical panel consisting of Sox10, p16, and cyclin D1 in differentiating MAP kinase-activated low-grade gliomas from piloid gliosis.
#neuropath #pathsky
journals.lww.com/ajsp/fulltex...
Congratulations to the new #AACR #TME working group Chair elect!!!
The one and only (best friend and colleague) @ashi-w.bsky.social
www.aacr.org/professional...
Golden weekend
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
A sausage shaped tumor with attached filamentous band
A squash preparation of a fibrillary neoplasm with myxoid background
Small rosettes in a squash preparation
H&E stained section of papillae with myxoid cores
Myxopapillary ependymoma grossly has a characteristic sausage-shaped appearance. Commonly found associated with the filum terminale, it has a fibrillary glial appearance in a myxoid background. Though previously categorized as CNS WHO grade 1, it is now considered grade 2 #pathsky #medsky #neuropath
Could I be added to the list? Thanks!
Among the Cancer-related Starter Packs currently available, I didn’t find one on Tumor Microenvironment.
Here, the list of who I found until now… If you want to be added, please reply below!
go.bsky.app/CtQMJyW
go.bsky.app/7xTwrrn
🧠 barriers & neurovasculature starter pack - please reply here if you are not on it yet & would like to be added 😊 go.bsky.app/RB6RXKy
