Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab!
www.science.org/doi/10.1126/...

Congratulations! What a great story!

Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer.

🔗: https://bit.ly/4v8miCC

Very cool to see this published! Congratulations!

👋 To all aneuploidy and chromosome instability aficionados check out the Consequences of Aneuploidy FASEB conference (Florida-USA 🏖️) co-organised with @peterlylab.bsky.social, Mike Lampson, Alison Taylor and myself: events.faseb.org/event/Aneupl...
👉 Deadline for abstract submission: August 3rd.

You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...

Congratulations!!

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity Ostendorf et al. show that activation of liver-X-receptors preconditions T cells to render them more receptive to adopting effector states upon activation.

Delighted to share our new paper on LXR agonism pre-conditioning T cells to more readily adopt effector states, out in @jem.org today. This was a long project started in @sohailtavazoie.bsky.social's lab and completed across the atlantic here in Berlin at Charité.

If you're a physics researcher, please sign this letter. Anyone in the biomedical sciences know of a similar letter for our fields? Or anyone interested in putting one together? ecr-openletter-stfc.github.io#sign-form

UK ‘could lose generation of scientists’ with cuts to projects and research facilities UK’s research funding body says best scientists are taking posts overseas due to lack of job stability at home

Physics are hit worst, but it's not just physics. @ukri.org, it's not too late to reverse course. www.theguardian.com/science/2026...

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...

In any case, regardless of any potential future emphasis on commercial enterprises, nothing that was said by Ian Chapman justifies the pause in research funding. Surely re-orienting can be achieved without this pause?

In contrast, in discovery science, research is published, and thereby available to benefit everyone, not just a few investors or company founders.

UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

As I predicted, the cutting of @ukri.org funding is to provide "more emphasis on commercialisation". This is an absolutely terrible decision. Most startups fail, or are bought by larger competitors. In both cases, their research is frequently lost from the public domain www.bbc.co.uk/news/article...

Awesome! Congratulations!

Congratulations!!

Exactly. Apart from the madness of halting funding for a period of time, this seems to herald a shift from long-term research investment to supporting short-term business interests.

It would be very helpful if this letter could be distributed to other news outlets as well, as it should be widely available and not paywalled.

Yes @ukri.org, please provide clarity and reasons for this chain of events. It would be a huge disadvantage to UK innovation if we went down a path of science funding that is similar to Trump's USA.

I wasn't even aware of that. Unbelievable.

It's also absolutely devastating to observe the UK being taken down a Trumpian path in yet one more context. We all were abhorred by news of slashed NIH study sections. And now the same is being done to us...by a "Labour" government.

This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.

I don't understand why the current grant rounds cannot continue as planned whilst the UKRI is repositioning itself. I also do not understand how this is not discussed in any news outlets. It will massively set back UK-based biomedical research.

Great news to see this out now! Congratulations!

I would also like to say that this was the first time I wrote a review across research groups, combining complementary expertise. It was a lot of fun, and I also learned a lot in the process.

Mitotic errors as triggers of cell death and inflammation - Nature Cell Biology Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or und...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...