Aligned with ferroptosis restricting circulating cancer cells, the BDH2–2,5-DHBA pathway protects mesenchymal cells from ferroptosis in the blood, boosting their capacity to seed secondary organs.

Restoring BDH2 or supplementing 2,5-DHBA rescues iron transfer, lysosomal pH, and ferroptosis resistance.

When BDH2 is lost, iron gets trapped in lysosomes, lysosomal pH rises, and contacts weaken. As a consequence, mesenchymal cells become highly vulnerable to ferroptosis.

We show that BDH2 is a key regulator of inter-organelle Fe(II) transfer. In melanocytic cells, BDH2 localizes at mitochondria–lysosome contacts. There it produces the siderophore 2,5-DHBA, which ferries Fe(II) into mitochondria. This supports respiration and lysosomal acidification.

Excited to share my PhD paper out now in Nature Metabolism! 🚨 We studied how intracellular iron trafficking controls ferroptosis vulnerability in melanoma. Shout-out to @agostinislab.bsky.social and all collaborators who made this possible! @natmetabolism.nature.com

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🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology - Nature Neuroscience Human microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are differentially regula...

Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...

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Hi Bluesky community 👋🏻🦋 just moved in! I’m a PhD student @ VIB (Belgium), interested in iron metabolism, membrane contact sites, ferroptosis, and cancer biology. If this sounds like something for you, take a look at our latest preprint 👉 www.researchsquare.com/article/rs-5...