Our latest work on PAM is out #GenomeMedicine
We show that PAM-T2D risk alleles result in "GLP-1 resistance".
I am so proud of this collaborative work championed by two incredible early career academics - Mahesh Umpathysivam & Elisa Araldi (not on BlueSky)
link.springer.com/article/10.1...
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
Tracking the details of an experiment in successively cited Methods sections
Congratulations Professor Gloyn! @Stanford @TheEndoSociety endocrinenews.endocrine.org/anna-gloyn-w... @annagloyn.bsky.social 🧪
Anna Gloyn (@annagloyn.bsky.social), Jie Liu, Noel Burtt, and Marcela Brissova from the PanKbase team gave a webinar for the HIRN webinar series. If you missed it and want to know how PanKbase might help compliment your type I diabetes research, watch it here: youtu.be/3qLiBdIOJhY?...
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It's a big day at the Academy as we welcome our 2025 Fellows 🎉
We’re celebrating 54 remarkable scientists joining our esteemed Fellowship of 1,450 leading researchers.
📣 Meet our new Fellows: ow.ly/VtGs50WmPqc
🌟 And our Honorary Fellows: ow.ly/4syL50WmPyi
And stay tuned for highlights!
A man presenting at a lectern with a PowerPoint presentation behind him
A woman asking a question into a microphone
A woman presenting at a lectern with a PowerPoint presentation behind her
Two people standing and talking to each other
🎉 Our New Fellows Admissions Day is in full swing!
We're welcoming an inspiring group of leaders advancing research and shaping the future of medicine! 💡
Really proud of this Exeter–Stanford collaboration identifying bi-allelic variants in PAX4 as a novel cause of transient neonatal diabetes—the first new genetic cause of this subtype described in over a decade. This work expands our understanding of beta cell development.
🔗 doi.org/10.1016/j.mo...
Our DEG explorer enables interactive visualizations of differential gene expression within human pancreatic islets. Data was generated from the integrated single-cell RNA sequencing from 140 human donors sourced from HPAP, IIDP, and Prodo. Check out the tutorial here: youtu.be/jL8SgEMF_sg?...
It was such a great session!!! I was honoured to present with you and Romi with superb Charing from Miriam!! 🧬
Please check out our new paper on bioRxiv evaluating genetic background influences on heterogenous responses to S64F MAFA!: www.biorxiv.org/content/10.1...
Thrilled and honored to be a part of this amazing session on rare genetics and GWAS in diabetes with @Romina39356029 @annagloyn.bsky.social and @miriam_udler ! #ADA2025
Dr. Anna Gloyn at #ADA2025: Multiomic data reveals diabetes heterogeneity, linking polygenic scores, islet traits, and regulatory networks.
@amdiabetesassn.bsky.social @annagloyn.bsky.social
#ADASciSessions #T2D #genomics #multiomics
PanKbase #ADA spotlight: PanKbase PI, Dr. Jie Liu, Associate Professor of Computational Medicine and Bioinformatics
Michigan Medical School will be presenting during the session "Decoding Diabetes—AI-Driven Advances in Genetic Research". June 23rd 3:15 PM - 4:15 PM. Look forward to seeing you there!
Edit to the time, Julie will now be presenting at 5:30pm.
PanKbase #ADA poster alert!!! Dr. Ha Vu (@hahvu.bsky.social) will be presenting her work on our PanKbase platform: "PanKbase Integrated Single-Cell Map—A Comprehensive Atlas of Human Pancreatic Islets Unlocking Insights into Type 1 and Type 2 Diabetes" Sunday, June 22 at 12:30p CT (Poster 2121-LB).
Planning your #ADA2025 visit? Don’t miss the NIDDK #DataScience Corner hosted by #dkNET!
📍 Between ADA Member Lounge & Product Theater 1
🗓 Visit during the reception or exhibit hours
🎉 Celebrate 75 years of #NIDDK!
🔗 dknet.org/data-science...
#ADASciSessions
Welcome to Chicago! If you're at the 85th Scientific Sessions of the #ADA, stop by the PanKbase booth 1047 in the exhibit hall to learn about the our updated single cell browser, ask questions, or give us feedback. youtu.be/sNEGvSIjh3M?...
Romina Bevacqua and PanKbase PI Anna Gloyn (@annagloyn.bsky.social) preview the presentations of #ADA session Genetic Regulation of Beta-Cell Mass and Function in Humans—Lessons from GWAS and Rare Genetics happening June 22, at 1:30 p.m. CT in Room W194 AB www.adameetingnews.org/genetic-regu...
Check out the platform at pankbase.org. Come see us at the 85th Scientific Sessions of the American Diabetes Association #ADA2025 #DataScience Booth 1047!!! We'd love to discuss more what we're doing and hear your feedback.
What is PanKbase? Watch our introduction video to find out: youtu.be/glGHni2tXGg?....
We're less than two weeks away from #ADA2025. PanKbase, booth 1047 will be located in the NIDDK #DataScience corner. Come see us to learn more about the platform and meet the PanKbase team.
PanKbase #ADA2025 spotlight: PI @annagloyn.bsky.social presents Sun. the 22nd at 2pm CDT. Session: Genetic Regulation of Beta-Cell Mass and Function in Humans: Lessons from GWAS and Rare Genetics. Her talk: "Integrating Multiomic Data to Understand Complex Gene Regulatory Networks in Islets"
Progress in Polygenic Risk Scores (PRS), which take multiple disease-modifying variants into account, are increasingly powerful tools to identify, predict and classify #diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Wishing I were Ferris!
🤯 40 years ago!
Out today from #HectorOrtega & #SethASharp A state of the art review on polygenic risk scores (#PRS) in diabetes. This is your #101 on what we currently know about them and their application to understanding disease heterogeneity & clinical translation.
Read for free here - rdcu.be/eprel
