Photo into the lecture hall of for the GRC Collagen

First full day of the #GRC #Collagen, obviously can't share anything, but there were already amazing talks!

This sounds really interesting! Eager to test it with some structures we have lying around. 👍

Okay, it's officially summer in Cologne, when I have to move our CryoEM machine from my office to an air conditioned room... ☀️(In Winter I am using it's heat for saving a little on heaters)

Are we really aging in bursts? If you are nearing 44 or 60, don't panic.

Do we really age in bursts like that recent study suggests? @drjenndowd.bsky.social yet again provides a terrific overview and explainer of that study.
🛟🧪 medsky 😷demography sociology

Thanks for this! The study was all over the news in Germany, but somehow I never cared to check. As a scientist myself I really should have 🙄 Overselling scientific findings is really a problem in our days - it decreases trust in the scientific process...

Und ich dachte es sei ein Witz... 😂 Olli glaube ich auch, oder zumindest hat er so getan...

There is an #science feed and #ML in structural biology feed, but is there an protein #crystallography feed? And if not would we need one 🤔

Only have some slides to explain protein domains and the importance to predict those to a public audience. Not sure if those help... 🤷‍♂️

Full ack... Sadly the AI proponents often do not share our caution 😉

I see your point, but I've heard this argument to often. "AF is different? - maybe just an important different confomer!" I do agree that crystal artefact exists and maybe this one deviation is upsold a little bit in the article, but in principle it's important to strengthen experimental strubio.

Is Folding@Home still a thing? I have the impression neuronal network based methods have outpaced the energy based prediction software so far....or did they change the basis for the client? 🤔

Not so fond of the war theme, but I agree with the message👍. I see so many projects just doing fancy -omics, trying to solve mechanisms - but sometimes you just have to get your hands dirty and purify that f*** protein.

room for improvement - it is an essential part of the scientific progress... So, is this just me?

Don't get me wrong, the study seems legit and I am eager to dig into it. Although every bit of focus on collagens research is great. But I don't like this "new" trend on reporting on practically unpublished results. I think we have a peer-review system for a reason and while there might be (2/n)

I am a structural biologist working with collagens, so naturally I am very interested. I only had time to skim over the paper, but I have to admit I currently fail to see why this is _major_ news. Especially, as it is not yet peer-reviewed. I frankly have more questions than answers (1/n)

I have the feeling that we lived in the golden age of medicine, already before AF. Knockouts mice, crispr/cas, mRNA vacs.These are all tremendous developments - independent of AF. Don't get me wrong: I am a structural biologist and use AF every day. It's great, but medicine was great already before

Congratulations to this year’s winner of the Young Investigator Award: Kristina Bubb from Cologne! @nystromlab.bsky.social

Thank you 🙏

Thanks! Finally I found it... 🥰 Somehow, expected it would be coot-1 or something along that line...

Thanks 👍

Hi, could you please add me to the science feed? I am a structural biologist. You'll find the University facility I supervise here px.uni-koeln.de and papers on my own page Gebauer.koeln thanks a lot!

I also thought about protein structures, but there is no left-handed alpha helix 🤔 but maybe that's the point? On the other hand the zigzag is not disordered... Frankly no idea... From which science area is it?

And still, it's relatively often wrong - at least for protein complexes 😉

I added support for Boltz1 so we can calculate ipSAE and other scores for pairwise protein-protein interactions on AF2, AF3, and Boltz1 models. Will add nucleic acids eventually. github.com/DunbrackLab/...

This sounds interesting and maybe exactly what I need. Plan to di some screening with #AF3 and a proper implementation ofna scoring function was still missing 👍 thanks!

It might be a stupid question, but given I have installed coot 1 via ccp4 on WSL how do I run it? Couldn't find an executable anywhere...

BMC has a solid JIF and welcomes all scientifically valid studies—so write up your story now and submit!

📩 DM me if you have questions or check out www.biomedcentral.com/collections/...

#ExtracellularMatrix #ECM #CellBiology #CallForPapers #StructuralBiology [2/2]

Get your data out now! 🚀

BMC has a special edition on “The Extracellular Matrix,” and I’m honoured to guest edit. We’re accepting manuscripts on all aspects of ECM, but if you know my background, you’ll know I’m especially excited about structural data and collagens 😉.
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Sorry, but this is a gross misrepresentation of Alphafold and FoldIt. Google did put together some old ideas (amino acid coevolution), some brilliant ideas about neural networks and a LOT of computer power to solve the problem. AFAIK they never used FoldI(the game), but CASPnto judge their result.

Wow, wasn't even aware, that the genbank was ever distributed by CD-ROM 😲