In vitro reconstitution of hippocampal cell assemblies Three-dimensional neuronal cultures, such as brain organoids, have proven effective for in vitro modeling of brain development and disease. However, it remains unclear whether these systems can intrin...

Are we born as a blank slate, or with a neural “operating system”?
We show hippocampal neurons self-organize into memory-like networks in a dish.
We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator.
www.biorxiv.org/content/10.6...

Scalable, affordable, submicron 3D imaging of multi-centimeter scale samples. - YouTube Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy. Authors: Cheng Gong, Pauline Affatato, Matt Fay, Sudha R...

Sharing new work from us+collaborators. We take a step toward making organ-scale, subcellular 3D imaging as scalable & affordable as next-gen sequencing, to eventually fuel next-gen of AI-foundational models of tissues, organs. www.biorxiv.org/content/10.1...
Videos: www.youtube.com/playlist?lis...

The key figure:

A milestone worth reflecting on - 1000 citations for our cleared tissue light sheet paper - the COLM.
Gratifying that core ideas have stood the test of time and are broadly adopted:
Cuvette-based sample mounting;
Virtual slit effect with rolling shutter CMOS;
and Linear adaptive offset correction!

Love this!! I don’t think I’ve ever seen anything like this before -- high-res light sheet microscopes designated for use by individual researchers in one lab!! Fantastic to see real-world impact emerging, starting with Bianca’s lab at JLG, Columbia!

3D Imaging Just Got Easier Columbia researchers have developed a powerful new microscope that could enable more scientists around the world to conduct cutting-edge biomedical research.

We’re proud to work with Dr. Tomer & his team at Columbia University to bring SLICE to life, a compact, affordable light-sheet microscope making 3D imaging more accessible worldwide.

📖 magazine.columbia.edu/article/3d-i...

@rtomer.bsky.social @columbiauniversity.bsky.social

#SLICE #lightsheet

We had to join the trend.

Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕

In science, there are no small people—just big ideas.
#ScienceMatters #STEM #Microscopy

Our digital times :-)

I suppose both mind states are needed. Fresh mind to think out-of-box and an informed mind to make sure it is indeed out-of-box.

Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...

Nothing better than that! :) (15h flights for us when visit family in India)

Not surprising!

this might have been a scheduled downtime for maintenance: "eRA's scheduled March maintenance will start at 7 p.m. (ET) on Saturday, March 8, 2025, and will end at 8 a.m. (ET) on Sunday March 9, 2025"

skin?

which one you get Rita? iHealth?

Congrats, fantastic work Reto and team!!

have ppl found any funders that support toolmaking? I want to keep making tools for people, but there is a seemingly irresistible force pushing us towards hypothesis-driven research. In my experience, funders don't want to hear about tech dev. Any insights? for both neuro & climate would be great tx

Synaptic basis of feature selectivity in hippocampal neurons - Nature A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...