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Posts by Michael Sinden

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Join IonOpticks and Dr Tim Heymann (@mannlab.bsky.social Max Planck Institute) for our webinar on March 27, combining advanced MS with optimised separations. Learn how workflows on Orbitrap Astral and ZenoTOF 8600 enable reproducible, high-performance proteomics. Registration opens Friday March 13.

1 month ago 2 2 0 0
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We're proud to support the next Montreal Mass Spectrometry Discussion Group event, including a featured talk by our nominated guest speaker, ‪@brendonseale.bsky.social

Join us Monday, March 17 from 6pm – 8pm at @umontreal.ca Université de Montréal – MIL Campus.

Great knowledge sharing initiative.

1 month ago 3 1 0 0
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Armed and ready: How Alejandro Brenes is uncovering the hidden lives of neutrophils in brain cancer Dr. Alejandro Brenes, a Wellcome Trust Early Career Fellow at the University of Edinburgh’s Institute for Regeneration and Repair, is uncovering hidden neutrophil populations in glioblastoma that coul...

Single-cell proteomics revealed neutrophil populations in glioblastoma that transcriptomics missed. Some may be blocking blood vessels & worsening outcomes. @ajbrenes.com on the hidden complexity of "soldier cells" & his journey from accidental researcher to Wellcome Trust fellow: bit.ly/46HuIGu

1 month ago 8 3 0 0
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Brunken et al. investigated the process that drives CIN through mechanisms relevant to early cancer development. Peptides separated on a Vanquish Neo with Aurora Rapid 8x75 XT column. MS performed on an Orbitrap Astral.

Learn more: bit.ly/4d3UuIH

Image from Brunken et al. bioRxiv (2026):

1 month ago 3 1 0 0
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IonOpticks recently visited China to meet researchers & partners across leading labs including Shanghai Jiao Tong University, PiHub, Suzhou Institute of Systems Medicine & Roche Shanghai. With our distributor OmicSolution, the team discussed LC-MS workflows & future collaboration across the region.

1 month ago 2 1 0 0
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IonOpticks’ Fabrice Odefrey will be in Hong Kong on March 30–31 and has limited availability to meet with local researchers. If your lab is working in proteomics or LC-MS workflows and would like to connect, please contact Fabrice directly via LinkedIn or WeChat to arrange a time during his visit.

1 month ago 2 1 0 0
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At SCIEX's #USHUPO2026 Seminar, Dr Tim Heymann showed how the ZenoTOF 8600 + Evosep Eno + Aurora XS columns deliver robust, high-quality data across single-cell, global & targeted proteomics, without rebuilding workflows. Up to 4,700 proteins from a single cell with low CVs using 1400ms ZT Scan DIA.

1 month ago 18 4 0 0
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Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis - Nature Communications The underlying molecular mechanisms of neuroinflammation and axonal damage in progressive multiple sclerosis remains unclear. Here, authors show proteomics results of human progressive multiple sclero...

Wang et al. shed light on the proteomic landscape of PMS, potential implications for biomarker discovery and future therapeutic targeting of neuroinflammatory pathways.
Data acquired on Orbitrap Fusion Lumos + EASY-nLC 1200, peptides separated on Aurora Ultimate 25x75 column.

go.nature.com/46lY3Gd

1 month ago 2 1 0 0
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With day 2 about to kick off, #USHUPO2026 is in full swing. Still building your agenda? With so many excellent poster presentations, here are some that we think are worth checking out today - all in the Regency Ballroom from 4:30pm - 6:30pm.

See the full list: bit.ly/3NZ3IMa

1 month ago 8 1 0 0
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Day 1 of #USHUPO2026 is underway with strong interest in our Nanoshield™ trap columns and Aurora 150 µm analytical range for robust, high-throughput workflows. Dr. TJ Blackburn’s trap comparison poster engaged valuable discussion. Visit Booth 7 to meet our team and discuss your separations needs.

1 month ago 4 1 0 0

Join SCIEX’s #USHUPO2026 lunch seminar to hear Tim Heymann present how pairing the ZenoTOF 8600 with Aurora XS columns delivers high-sensitivity, stable, and reproducible proteomics workflows, powering applications from single-cell analysis to large-scale discovery studies.

1 month ago 7 1 0 0
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Are you at #USHUPO2026? Catch Dr. TJ Blackburn's lightning talk from 3:15pm to 4:30pm (Grand DE).

Can’t make it? TJ will also share this work as a poster presentation P10.03 in the Regency Ballroom from 4:30pm - 6:30pm.

Learn about our full scientific presence at US HUPO: bit.ly/3NZ3IMa

1 month ago 2 1 0 0
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Beyond the ‘wizard in the basement’: How Luke Gamon is simplifying spatial proteomics for clinical discovery Assistant Professor Luke Gamon, at the University of Copenhagen, is rethinking how we study heart disease by zooming in on the microscopic battles that occur within atherosclerotic plaques. Throughout...

"If you know your sample well, you can do meaningful spatial proteomics with just your hands and a microscope, basically." @lgamon.bsky.social is proving that breakthrough science doesn't always need expensive automation. Read about his accessible approach to heart disease research: bit.ly/3MDkjVc

2 months ago 3 1 0 0
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Not long until #USHUPO2026 - check out Dr. TJ Blackburn’s lightning talk & poster presentation P10.03 on Mon, Feb 23 from 3:15pm. Learn the science behind NanoShield™ trap columns, how they perform in real workflows, and what that means for your robustness and consistency.
Learn more: bit.ly/3NZ3IMa

2 months ago 1 1 0 0
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Today we recognise and celebrate the women of IonOpticks on the UN's International Day of Women & Girls in Science. This year's theme reflects the importance of inclusion, opportunity & progress. Thank you for the talent, care & impact you bring to our team & the scientific community every day.

2 months ago 3 1 0 0
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IonOpticks was proud to attend the @ubuntuproteomix.bsky.social Summer School for 2026. Dr @jsandow.bsky.social presented on chromatography fundamentals, we sponsored three students & provided our popular IO hats for all. Thanks to the organisers for another great event & we look forward to 2027.

2 months ago 6 1 0 0
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Heard the hype about NanoShield™? Join Greta Briedytė at #LorneProteomics poster #105 to see how our new trap column improves sample cleanliness, extends analytical column life, reduces loading time, and delivers near direct-injection performance. Grab the application note at our booth.

2 months ago 5 1 0 0
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After a great day of talks and posters at #LorneProteomics 2026, it was fantastic to host our IonOpticks Peaks and Pints event at the Lorne Hotel. Thanks to the 68 guests who joined us for a relaxed evening of conversation and catching up. Looking forward to another great day ahead.

2 months ago 3 1 0 1
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Poster Spotlight: Emery-Corbin et al, #LorneProteomics poster #34, benchmark plasma proteomics workflows using Aurora® Ultimate™ 25×75 and Elite™ 15×75 columns. Their study shows workflow selection must be cohort-specific, revealing distinct sub-proteomes across clinical and translational settings.

2 months ago 1 1 0 0
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Poster Spotlight: Multari et al’s #LorneProteomics poster #3 explores single-cell proteomics in Diffuse Midline Glioma (DMG). Using IonOpticks Aurora Rapid 8×75 column, it reveals radiation response heterogeneity and early resistance mechanisms, supporting discovery of future therapeutic targets.

2 months ago 4 1 0 0
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Day one, #LorneProteomics ready.
Our full delegation is on the ground and ready to connect, answer your questions, and explore how IonOpticks can help you get the most out of your LC-MS workflows. Stop by the booth during the breaks today for a chat.

Better columns. Better data. Better research.

2 months ago 3 1 0 0
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IonOpticks is at APS’s 31st Lorne Symposium (Booth 14). Discover Gen 4 Aurora Series® 75 & 150 µm columns, NanoShield™ C18 trap columns, and HeatSync™ heating. Meet our team and CCO Darren Sher, and join ‘Peaks and Pints’ at the Lorne Hotel: lnkd.in/gCEFyRiM

2 months ago 2 1 0 0
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Shout out to our sponsors who put a little #SwagInTheBag! @evosep.bsky.social #DCYPHR @diplomics.bsky.social @ionopticks.bsky.social @resynbio.bsky.social

2 months ago 5 2 0 0
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Register now: bit.ly/LornePeaksan...
Heading to next week’s Lorne Proteomics Symposium 2026 at Mantra Lorne? With just 2 days left to register, now’s the time to lock in your spot at IonOpticks’ 'Peaks and Pints' user event on Friday 6 February, 6-10pm.

2 months ago 3 1 0 0
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IonOpticks appoints Darren Sher as Chief Commercial Officer to lead global commercial strategy IonOpticks IonOpticks, a world-leading provider of chromatography solutions, today announce two key appointments to strengthen its global operations, enhancing access and support for the LC-MS industry. Erik Ver...

IonOpticks is pleased to announce the appointment of Darren Sher as Chief Commercial Officer: a strategic executive role providing coordinated leadership across global sales, marketing, customer support + customer processes as the company continues to scale internationally. Read the full release.

2 months ago 2 1 0 0
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IonOpticks is proud to sponsor the 2026 @ubuntuproteomix.bsky.social in George, South Africa. Join IonOpticks' CPO @jsandow.bsky.social, on site all week and catch his sponsor presentation “Chromatography Fundamentals for Proteomic Analysis” Thursday 5 Feb, 10:30am - 12:30pm.

2 months ago 4 1 0 0
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Unlocking sensitivity for low-sample-input quantitative proteomics using ZT Scan DIA on the ZenoTOF 8600 system This technical note demonstrates how the ZenoTOF 8600 system, powered by ZT Scan DIA 2.0, enables high-depth quantitative proteomics from sub-nanogram sample amounts using data-independent ...

IonOpticks Aurora® Elite™ 15x75 XS columns with the @sciex.bsky.social ZenoTOF 8600 deliver standout low-input proteomics. SCIEX's latest app note shows ZT Scan DIA 2.0 identifying 4,000+ proteins from just 62.5 pg, with up to 94% more quantifiable proteins and CVs below 20%. Read online:

2 months ago 5 1 0 0
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With Lorne Proteomics just a week away, join the IonOpticks team next Friday (6–9pm) at the Lorne Hotel for Peaks & Pints: an informal meetup where proteomics meets pints. Cold drinks, sharp peaks, great company.

Registration essential: bit.ly/LornePeaksan...

2 months ago 3 1 0 0
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Preprint: Deep learning-driven fragment ion selection for improved quantification in MS based proteomics - IonOpticks This Mann lab study into deep learning-driven fragment ion selection by Vu et al. used IonOpticks Aurora Rapid 5×75 UHPLC columns.

QuantSelect: Mann lab's new deep learning framework improves DIA proteomics quantification by 12-15%. Validated on Orbitrap Astral + Evosep One with Aurora Rapid 5x75 columns. Up to 4× better sensitivity in differential expression analysis.

Learn more: bit.ly/3NyqqKG

@mpibiochem.bsky.social

2 months ago 4 1 0 0
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We’re proud to support the Queensland Mass Spectrometry Symposium 2026, which kicks off next week at the Global Change Institute.

Fabrice, our Distribution Channel Manager - APACI, will attend on both days, January 28-29. If you’ll be there, see if you can spot Fabrice - he'd love to connect

3 months ago 2 1 0 0