Intrinsically disordered regions as facilitators of the transcription factor target search - Nature Reviews Genetics Intrinsically disordered domains (IDRs) are increasingly appreciated as important components of protein function. This Perspective discusses the emerging evidence for IDRs from transcription factors a...

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Excited to share our recent Perspective on the role of intrinsically disordered regions of eukaryotic transcription factors in the target search process 🔎:
www.nature.com/articles/s41... 😱

Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors Abstract. Activation domains (ADs) within transcription factors (TFs) induce gene expression by recruiting coactivators such as the Mediator complex. Coact

Maybe a bit late, but I want to bring this article to this platform as well!

Incredible work done by Vladimir Mindel and Dr. Sagie Brodsky!

academic.oup.com/nar/article/...