I'm not saying fenebrutinib DOESN'T work in PPMS, I'm just saying this study doesn't prove that it DOES work. I am open to other viewpoints on this.

#AANAM2026 non-inferiority study of fenebrutinib vs ocrelizumab in PPMS. fenebrutinib is non-inferior to ocrelizumab BUT the inactive PPMS population differs from the original ORATORIO trial, so non-inferior to what? I don't have great confidence in ocrelizumab's efficacy in this population.

My Take away: disability level should not exclude PPMS pts from ocrelizumab tx. Age and active vs. inactive MS continue to be considerations.

#AANAM2026 ocrelizumab vs placebo in older and more disabled PPMS patients: delayed disability progression in EDSS and 9 hole peg. Better in younger, Active MS, and More disabled subgroups.

Exciting results in the clinical trial Plenary at #AANAM2026.
the first positive phase 3 trial in MOGAD! satralizumab significantly reduced relapse rates in relapsing MOGAD compared to placebo with stable baseline open label immunosuppression allowed. IVSM use & MRI also favored satralizumab.

Exciting results in the clinical trial Plenary at #AANAM2026.
First, phase 2 trial on neuro protection in acute optic neuritis. Privosegtor 3mg/kg dosed within 12 days of symptoms WITH concurrent IVSM showed benefit in low contrast visual acuity and OCT. notably aqp4+ excluded.

#AAN2026 #neurosky
Today's presidential plenary session. Consistent examples of the importance of basic science translation in neurology. From understanding the role of nuclear porins in sporadic ALS studying childhood genetic disorders. The future of translational neurologic science is bright!

#AANAM #neurosky On future physician shortages: US physician workforce is expected to be at only 88% of need in 2038, Neurology is expected to be fully staffed at 104%. The room of neurologists disagreed.

Do we have enough neurologists in the training pathway?

bhw.hrsa.gov/sites/defaul...

Newest publication out from several of the outstanding trainees at Barrow Neurology: necrotizing granulomatous encephalitis after endovascular therapy. Congratulations Drs Kaneko, Khanna, and Malaty!

doi.org/10.1212/WNL....

Day 3 of #ECTRIMS2025
extension results for ravulizumab in NMO disease (AQP4+). 0 relapses in 105 patient years! absolutely incredible efficacy!

Our abstract on High Efficacy Therapy Use by race/ethnicity. We found that while non-White individuals had higher rates of HET use, the association disappeared when adjusted for disability implying that clinical factors drive prescription patterns. # ECTRIMS2025

#ECTRIMS2025. only 50% of MS patients are up to date vaccines. Inactivated vaccines are NOT associated with relapses and are safe to take in MS. Vaccines are a safe way to reduce infection risk on DMTs. live vaccines may be contraindicated on tx but Can be given 4 weeks before DMT initiation.

Imaging in chronic inflammation session at #ECTRIMS2025 was quite interesting. Several abstracts looking at associations between choroid plexus size and PIRA and chronic active MS lesions. A future easily accessible progressive MS biomarker? #multiplesclerosis

eposter up and available at #ECTRIMS2025. HTN awareness is lower in Hispanic people with MS than the general population and lower than a recent predominantly White MS cohort. younger age is associated with worse awareness, but integrated healthcare is associated with better awareness.

P113 American Heart Association Blood Pressure Categories Have Stronger Associations with Worsening Disability than other Hypertension Metrics In Multiple Sclerosis.
- AHA stage II HTN may be a better tool than SBP or DBP alone for future MS HTN comorbidity research
Come visit!

-cerebellar lesions now count as a typical presentation

-some additional new "typical" MRI findings
-confidence of diagnostic criteria now separated by quality of antibody test

AQP4 + NMOSD disease is in fact a disease not a syndrome and is now named as such.
-NMO spectrum is now only the people who are antibody negative incomplete syndromes should be named as they present (recurrent ON, recurrent TM etc)

2025 NMO criteria. Lots of nomenclature updates but the core is still what we already knew...

One difference from the broad understanding of last year's release... Paramagnetic rim lesions can only be used as secondary confirmation in people without DIS (people who need 2 forms of confirmation) they can not be used as the only confirmatory test in people who only need one confirmatory test

#ECTRIMS2025
Lots of diagnostic updates on day 1! 2024 McDonald criteria re-released in conjunction with the lancet papers last week. Reaffirming most of the major changes and attempting to provide better algorithms. Heads up the online PDF had errors last week. Re-download now if you got it before.

Looking Forward to a wonderful three days of scientific discussion around improving the care of MS! #ECTRIMS2025

Fall history moderates the relationship between concern about falling and reactive stepping performance in people with multiple sclerosis Reactive balance (quick motoric responses to an external balance challenge) and affective characteristics are linked to falls and negatively impacted …

fear of falling and objectively slower reactive stepping are associated with each other in people with MS, especially in those with a history of falls. Thanks Dan Peterson for inviting me to collaborate. I look forward to working with you in the future. www.sciencedirect.com/science/arti...

Hypertension Awareness Gaps in Patients With Multiple Sclerosis: Michael Robers, MD, MS The assistant professor of neurology at Barrow Neurological Institute talked about the lack of public awareness for hypertension among individuals with MS despite many meeting diagnostic criteria. [W...

I haven't had a chance to post this, but I had the opportunity to discuss our research on Hypertension Awareness with neurology live at CMSC. check out this short highlight!

Hypertension Awareness Gaps in Patients With Multiple Sclerosis: Michael Robers, MD, MS share.google/wTGUzi2pwaX4...

Nice that Barrow was recognized for neurological care, but I'm especially happy to see our #MultipleSclerosis center recognized as a "stand out specialty".

rankings.newsweek.com/americas-bes...

www.forbes.com/sites/robert...

These changes and loss of access to loans will destroy medical students ability to be full time students. Want to guarantee worse doctors? This is it. Call your representatives and oppose these changes!

here is Maya Jayaram's and my abstract on HTN unawareness in MS. 55% of MS pts with HTN are unaware!

Check out: Disparities of Hypertension Awareness in Multiple Sclerosis: Age, Sex, and Severity @ 2025 Annual Meeting of the Consortium of Multiple Sclerosis Centers cmsc.confex.com/cmsc/2025/me...

comorbidities such as hypertension (HTN) are important in #multipleSclerosis care. A Gap in care exists where many people with MS are unaware they have HTN. I look forward to presenting our findings on HTN Unawareness today at #CMSC In the "Disease Management" session (north 122abc from 3-5pm).

#CMSC great tips for energy conservation at the interdisciplinary approach to wellness session. moving high frequency items to arm level storage in the home reduces the number of times people have to bend over or reach over their head both of which take more energy.

at the opening lecture for #CMSC discussing the history and importance of comprehensive MS care. one of the things I enjoy about this conference is the interdisciplinary discussions and networking. looking forward to a great 4 days focused on the care of MS!

How Unsaturated Fats Help You Process Carbs (and Why That Matters for Diabetes) When you think about managing diabetes, you probably focus on carbs. But here’s a little-known trick: Pairing carbs with healthy fats—specifically unsaturated fats—can slow digestion, help keep blood…

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