🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social
📅 1 May–15 June 2026
📩 search2026@igmm.cnrs.fr
📎Full information 👇
#LifeScience #MolecularBiology #Research #PI #CNRS
📣📣 Deadline approaching 📣📣 (Please re-post)
If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the
@i2bcparissaclay.bsky.social
Diversity of topics, interdisciplinary environment and excellent platform support! Recommended!
So admittedly: the extra coverage in nCATs comes at an immense loss of coverage…
For adaptive sampling the coverage is more like 20-50 fold (half a promethion cell; nCATS was on a single minion). With adaptive sampling we’re indeed targeting ~ 3% of the genome
We have used both nCATS and adaptive sampling. nCATS got us around 100-200x coverage over ~200 kb of the mouse genome. But we didn’t do multi-plex. Can’t you just leave the 5’ phospho step out?
Spring has arrived on campus
Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! 📢
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University 🇩🇰
Deadline May 1 👇
Please share with anyone who might be interested!
Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!
We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...
We;re hiring Junior Group Leaders! 🔬✨
We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment.
www.nki.nl/news-events/...
Congratulations Agnese! Happy to have you in the Paris area
We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology
#CellBiology #ComputationalBiology #TeamLeaders#I2BC
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Focus on interdisciplinary projects in structural, molecular, cellular and computational biology. Deadline is the 22nd of April. DM me if you want to get more info!
🚨🚨🚨 My institute, the @i2bcparissaclay.bsky.social in beautiful Gif-sur-Yvette and part of @univparissaclay.bsky.social, is recruiting group leaders!
Announcement here:
www.i2bc.paris-saclay.fr/join-i2bc/te...
Open to early career scientist from anywhere or mid-career already in France. Please RB!
Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
Thank you Max, I’ll transmit the message 😃
That looked like an excellent visit!
New paper from the Feil lab! congratulations🍾👏
Great thread below ⤵️
@agencerecherche.bsky.social @frm-officiel.bsky.social Thank you for your support
@cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social @biolum-montpellier.bsky.social
#epigenetics
This has been an exciting collab with (all non-BS): Yui Imaizumi in Robert Feil’s lab (@igmm-montpel.bsky.social ), Francois Charon and Benoit Moindrot from @i2bcparissaclay.bsky.social and Jean-Charles Cadoret (@ijmonod.bsky.social) and others. Thanks to @agencerecherche.bsky.social for funding.
How about 3D organization? Correlations emerge at larger scale, but our high-res allelic data has poor overlap, both for timing and for boundaries between repli domains and TADs. At imprinted domains, regulators that desynchronize replication timing also uncouple links with genome organization (4/n)
(2) perturbing lncRNA expression on the early chromosome delays replication, but further away. Methylation and lncRNA expression thus provide means to locally override the intrinsic replication program (3/n)
Imprinted domains can replicate asynchronously, making them excellent study objects. High-res allelic Capture Repli-seq reveals unexpected outcomes: (1) removal of DNA methylation from the tiny Imprinting Control Region on the late replicating chromosome advances replication over 100s of kbs (2/n)
🔔 New paper alert 🔔 www.nature.com/articles/s41...
Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)
Bravo Anne and colleagues!
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...
Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
