The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...

Preprint alert 🚨Happy to share my first Posdoc manuscript from the Vos lab @voslab.org. We introduce GATO-seq, a high-throughput, fully in vitro technique that maps RNA polymerases at base pair resolution over time. Using it, we found a new pause state of Pol II: sidetracking tinyurl.com/superpause

🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

Amazing work from Bonnie Su and Laura Caccianini from our group, the lab of @lucas.farnunglab.com with @mosorio91.bsky.social and Alex Stone and the lab of @andersshansen.bsky.social with Masahiro Nagano!

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Summer Undergraduate Research Experience | HHMI The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

Congratulations Filiz! Beautiful work!

My dad has one of these. Fun cars :)

Same!

Congratulations Ben!

Congratulations Jimmy!

Page A04 View the The Journal for Friday, March 7, 2025

I wrote an opinion piece for my hometown South Carolina newspaper that was published today. Support science funding for our future! Standing up for science today and always! tinyurl.com/mr3vuphr

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

The short talk abstract and scholarship deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation is tomorrow (23 January)! Get your abstracts in to be part of a great meeting in Banff this spring. @keystonesymposia.bsky.social keysym.us/KSChromatin25

Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!

KSQA: Dr. Seychelle M. Vos (Interplay of Chromatin Architecture) YouTube video by KeystoneSymposia

Start off the New Year on a high note and submit your abstract for @KeystoneSymp Interplay of #Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away on January 9th! tinyurl.com/txn-keystone #KSChromatin25

The structural basis for RNA slicing by human Argonaute2 Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.

Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing

This work would not have been possible without amazing collaborators Jimmy Ly, Luisa Welp, Dan Lu, Fabian Schulte, and Henning Urlaub. @whiteheadinstitute.bsky.social

Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA

The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting. Join us in Banff for some awesome science. #KSChromatin25