Join me this Tuesday at @kcnhub.bsky.social, where I’ll be sharing new computational insights into how the spinal cord processes complex touch—and what this reveals about allodynia and spinal cord stimulation.

🕔 Nov 25th 9:30-11am
📍 Krembil Brain Institute (@uhnresearch.ca)
🔗 tinyurl.com/287wdypa

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW

Adaptation in somatosensory afferents improves rate and temporal coding of vibrotactile stimulus features Adaptation is a common neural phenomenon wherein sustained stimulation evokes fewer action potentials (spikes) over time. Rather than simply reduce firing rate, adaptation may help neurons form better...

My first-ever 1st author paper is now on bioRxiv 🙂 www.biorxiv.org/content/10.1...

Special thanks to my masters supervisor Steve Prescott!

Also with @lauramedlock.bsky.social , @cdedek.bsky.social & more

Congrats Adel, incredible work. 👏👏

You've got this. 💪

Thank you so much! Steve and I put a lot of careful design and analysis into this work.

Probably my favourite work of my PhD out now on #bioRxiv 🎯

The value of equity, diversity, and inclusion principles... : PAIN An abstract is unavailable.

"Denial that certain diversities exist or banning the use of terminologies and classifications along spectrums does not negate the reality of personal identity and the underlying neurobiology". Thank you @iasp.bsky.social and @karenddavis.bsky.social 🧪#PainResearch

journals.lww.com/pain/fulltex...

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...

Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...

Chronic Pain Afflicts Billions of People. It’s Time for a Revolution. As many as two billion people suffer from it — including me. Can science finally bring us relief?

In-depth article on chronic pain, with my friend @robgereau.bsky.social and Allan Basbaum heavily interviewed as scientists studying pain: ‘We die in pain, we don’t die of pain.’

www.nytimes.com/2025/01/12/m...

Latest work out of the Prescott Lab on #pain sensitivity in different (nociceptive vs. non-nociceptive) afferents. 🔦

Congratulations to the team, Mike! Excited to dig into this work.

Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received sc...

Out now in @sfnjournals.bsky.social! 👋 Our latest work on #touch and vibration sensing in rodent #mechanoreceptors.

A beautiful experimental and computational collaboration thanks to the whole Prescott Lab team.

www.jneurosci.org/content/44/4...