This is beautiful. I’m curious, if you take Brian hie and Peter kim’s approach with llms to “improve” your small protein domains, do you think you’ll see a systematic trend to more or less dynamics?

Suggestions for a chemically titratable promoter in human cell culture? Titration of dox with TetOn gives a bimodal response (largely changes on:off ratio). I miss my beautifully tunable yeast system from Azizoglu, Brent and Rudolf (elifesciences.org/articles/69549) #synbio #RNA

Amazing, well done.