Glucocorticoid-induced osteoporosis: novel concepts and clinical implications Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...

Overcoming functional and translational challenges of cellular immunotherapies for solid tumors Though successful in hematologic cancers, cell therapies face major barriers in solid tumors. Chen et al. review functional and translational obstacles undermining autologous and allogeneic cell-based...

Overcoming functional and translational challenges of cellular immunotherapies for solid tumors: Cancer Cell www.cell.com/cancer-cell/...

Wildlife trade drives animal-to-human pathogen transmission over 40 years The wildlife trade affects a quarter of terrestrial vertebrates and creates opportunities for cross-species pathogen transmission, but its precise role in shaping animal-human pathogen exchange remain...

Wildlife trade drives animal-to-human pathogen transmission over 40 years | Science www.science.org/doi/10.1126/...

Application of luminescence-producing Mycobacterium tuberculosis strains for evaluating anti-tuberculosis drug and vaccine efficacy in vitro and in vivo - BMC Infectious Diseases BMC Infectious Diseases - Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major public health problem worldwide. The development of effective drugs and vaccines remains...

link.springer.com/article/10.1...

The Intermediate-mass Black Hole in Omega Centauri: Constraints on Accretion from JWST The Intermediate-mass Black Hole in Omega Centauri: Constraints on Accretion from JWST, Chen, Steven, Hare, Jeremy, Kargaltsev, Oleg, Yang, Hui, Cioffi, Denis, Häberle, Maximilian, Seth, Anil

The Intermediate-mass Black Hole in Omega Centauri: Constraints on Accretion from JWST
doi.org/10.3847/1538...
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Lipid droplet-induced T cell death sustains autoimmune tissue inflammation Kumar et al. identify a metabolically controlled trait of CD4+ T cells in autoimmune disease. Exposed to fatty acids in rheumatoid joints, they form lipid droplets containing pore-forming gasdermin D and its activator zDHHC5. These droplets induce plasma membrane lysis, resulting in the leakage of intracellular contents and tissue inflammation.

www.cell.com/cell-metabol...

Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis Compartmentalized BCAA metabolism regulates CRC dissemination through UMP-mediated stabilization of vimentin, leading to pro-migrative traits. Targeting of BCAA metabolism by dietary restriction or repurposing of UMP biosynthesis inhibitors arrests CRC dissemination. Compartmentalized BCAA metabolism is a pan-cancer biomarker for poor survival. Our study thus links metabolic reprogramming to CRC metastasis.

www.cell.com/cell-metabol...

Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer Our work reveals the plasticity of pancreatic ductal adenocarcinoma tumor cell states and their interactions with the tumor microenvironment during chemotherapy, highlighting CD276/B7-H3 as a key regu...

Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer - Gastroenterology www.gastrojournal.org/article/S001...

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer Hubbi et al. reveal that hypoxia and pancreatic tumor interstitial fluid cooperate to suppress ferroptosis in pancreatic cancer through HIF-2 activity. By transcriptionally regulating glutathione meta...

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer: Molecular Cell www.cell.com/molecular-ce...

Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis - Megan Ritson, Hugh S Markus, Eric L Harshfield, 2026 Background: Epidemiological evidence suggests associations between substance use disorders and risk of stroke, but whether these are due to confounding or are t...

journals.sagepub.com/doi/full/10....

GLP-1 Receptor Agonists | NEJM Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and obesity. GLP-1 receptor ago...

GLP-1 Receptor Agonists | New England Journal of Medicine www.nejm.org/doi/full/10....

POEMS syndrome: a neuromuscular perspective Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes (POEMS) syndrome is a rare multisystemic disorder associated with plasma cell dyscrasia, most commonly presenting with peripher...

jnnp.bmj.com/content/97/4...

Machine learning assisted differentiation of low acuity patients at dispatch: The MADLAD randomized controlled trial In this randomized clinical trial, Douglas Nils Spangler and colleagues assess the potential of a machine learning (ML)–based triage tool to improve emergency triage by supporting dispatchers in ident...

journals.plos.org/plosmedicine...

Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study Objectives To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and ot...

www.bmj.com/content/392/...

An improved version of the early histone HCl extraction protocol Acid extraction has been and remains one of the most widely used methods for preparing histones. Over the years, dilute hydrochloric or sulphuric acid solutions have been used alternately for histone ...

cdnsciencepub.com/doi/10.1139/...

Walled-Off Pancreatic Necrosis | NEJM A woman with a history of necrotizing pancreatitis presented with abdominal pain and fevers. CT showed a fluid collection with gas and septations in the pancreatic region. A retroperitoneal necrose...

Walled-Off Pancreatic Necrosis | New England Journal of Medicine www.nejm.org/doi/full/10....

Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure | Circulation Research BACKGROUND: The prevalence of heart failure is increasing globally, with poor prognosis, highlighting the need for novel therapeutic strategies. PKCα (protein kinase C alpha), encoded by PRKCA, plays ...

Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure | Circulation Research www.ahajournals.org/doi/10.1161/...

Politicisation of the US FDA: eroding integrity and trust The principle that medicines should not reach patients without strong safety guardrails forms the bedrock of the US Food and Drug Administration (FDA). The FDA shapes decisions about which medicines r...

Politicisation of the US FDA: eroding integrity and trust - The Lancet www.thelancet.com/journals/lan...

Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling Wang et al. show that maltol, a common food additive, accumulates in individuals with type 2 diabetes and promotes bone fragility under hyperglycemia, highlighting the need to reassess food additive s...

Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling: Cell Metabolism www.cell.com/cell-metabol...

Wearable technologies in clinical trials for drug development: trends and emerging opportunities Nature Reviews Drug Discovery - Wearable technologies, which provide new tools to capture physiological and behavioural endpoints in real-world settings, are increasingly being integrated into...

www.nature.com/articles/s41...

Tuberculosis Cases and Deaths Averted by PEPFAR | NEJM Tuberculosis remains a leading cause of death worldwide among persons with HIV. In this report, the effect of the PEPFAR program on incident cases of tuberculosis and related deaths is presented.

Tuberculosis Cases and Deaths Averted by PEPFAR | New England Journal of Medicine www.nejm.org/doi/full/10....

OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration:

www.jacc.org/doi/10.1016/...

Child Neurology: Multiple Genetic Etiologies Causing Dandy-Walker Variant With Microcephaly, Epilepsy, and Global Developmental Delay | Neurology Dandy-Walker syndrome is typically characterized by near-complete cerebellar vermis agenesis, enlarged posterior fossa, and dilated fourth ventricle. By contrast, Dandy-Walker variant (DWv) shows mild...

www.neurology.org/doi/10.1212/...

Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial | NEJM Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We c...

Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial | New England Journal of Medicine www.nejm.org/doi/full/10....

The contribution of viral toxins to infection and pathogenesis | mBio Viral pathogenesis is a complex process involving both the virus and the host. Tissue damage caused during viral infection can result from the virus and/or the host immune response. A prerequisite for...

The contribution of viral toxins to infection and pathogenesis | mBio journals.asm.org/doi/10.1128/...

New and emerging treatments for anxiety disorders Anxiety disorders affect a large portion of the population. While standard treatments show efficacy, rates of treatment non-response and relapse highlight the need to augment existing treatments or de...

www.bmj.com/content/392/...

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

www.nature.com/articles/s41...

Frontiers | Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential The maintenance of protein homeostasis is essential for neuronal survival and function; however, it progressively declines with age, predisposing the brain t...

www.frontiersin.org/journals/agi...

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry AbstractBackground and Aims. To assess in-hospital and 1-year cause-specific outcomes in the contemporary European Society of Cardiology (ESC) Heart Failur

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry url: academic.oup.com/eurheartj/ar...

Sleep your way to better metabolic health World Sleep Day, observed this year on March 13, calls for recognition of the central role of sleep in physical and mental health and for the promotion of healthy sleep habits. For children in particu...

Sleep your way to better metabolic health - The Lancet Diabetes & Endocrinology www.thelancet.com/journals/lan...