Congratulations to BCRF investigator Dr. Steffi Oesterreich for receiving this year’s AACR (@theaacr.bsky.social) Distinguished Lectureship in Breast Cancer Research Award at #SABCS24. She has made groundbreaking contributions in translational breast cancer research. @sabcs.bsky.social

Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯

www.nature.com/articles/s41...

More than 75 Nobel Prize winners signed a letter urging senators not to confirm Robert F. Kennedy Jr. to lead the Department of Health and Human Services. The letter marks the first time in recent memory that Nobel laureates have banded together against a cabinet choice. nyti.ms/41uQueD

Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system - Nature Biotechnology Biomacromolecules are delivered across the blood–brain barrier when administered systemically.

Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system

"A system that facilitates delivery into the CNS through γ-secretase-mediated transcytosis."

www.nature.com/articles/s41...

The @dfcibreastonc.bsky.social team is on its way— see you all soon in San Antonio! #SABCS24

Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020 This model-based study using population-level cancer mortality data evaluates the association of prevention, screening, and treatment interventions with cumulative number of cancer deaths averted from...

Estimated 6 Million deaths from breast, cervical, colorectal, lung, and prostate cancers were averted in the US from 1975 to 2020 due to Prevention, Screening, and Treatment Advances @jama.com

jamanetwork.com/journals/jam...

Shout - University of Oregon YouTube video by mrrustyduck

www.youtube.com/watch?v=vtFw...

BIG TEN CHAMPS! YOUR OREGON DUCKS!

(Image Oregon Football)

#champions #B1G #GoDucks

The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits
@science.org

science.org/doi/10.1126/...
science.org/doi/10.1126/...
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Zenocutuzumab, a HER2/3 bispecific, now approved for #NRG1 fusion positive NSCLC and pancreatic cancers. Best to use RNA-seq to find this fusion - DNA based NGS often misses it. Outcomes poor with standard therapy - this is an an important approval. #OncSky #LCSM

www.fda.gov/drugs/resour...

Big news. Dr. Druker literally tranformed care for chronic myelogenous leukemia.

His rationale for stepping down is a warning to centers everywhere - innovation takes vision and sustained commitment.

Lose the mission, lose the team.

Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.

SONIA trial - Pts with ER+ breast cancer beginning treatment in the metastatic setting randomized to 1st line vs 2nd line use of CDK4/6 inhibitor (+ endocrine therapy). No sig difference in PFS.

www.nature.com/articles/s41...

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O