Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

We next asked if target search could be facilitated by other TF molecules. Decreasing Gal4 protein levels increased target search time, indicating that Gal4 target search is cooperative and may involve self-interactions. In addition, cooperativity also stabilizes Gal4 on DNA. 5/10

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A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization - Nature G2E3-catalysed H3K14 mono-ubiquitination is crucial for SUV39H compartmentalization and H3K9 trimethylation in pericentromeric heterochromatin, which is essential for proper euchromatin organization a...

www.nature.com/articles/s41...

PADIT-seq reveals multiple overlapping binding sites determined transcription factor occupancy YouTube video by Shubham Khetan

he partnered with The Happy Slate to create a 3-minute animation explaining this work! please check it out :)

youtu.be/KFPZ9Rhjs4Y

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....

@imperiallifesci.bsky.social

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...