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Posts by HellSap

Photo I took of these wonderful people (the faces of whom I’ve blacked out) singing happy Birthday to their lovely old dog at a bar I was at tonight in Portland

Photo I took of these wonderful people (the faces of whom I’ve blacked out) singing happy Birthday to their lovely old dog at a bar I was at tonight in Portland

I was at a dog-friendly bar in NW Portland tonight and a table behind me started singing Happy Birthday and then I realized it wasn’t for a person but a really old dog who was wearing a crown and he was old and fucking adorable and I love this city

3 days ago 4562 808 43 42
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📝 A week left until early bird for #UMAD2026 ends on April 30th! Out of 113 entrants, here's a sneak peek at our leaderboard!

📻 More side games announcements to come this week!

🕐 August 21-23, 2026
📷 550 Rue Richmond, Montréal, QC H3J 2R9
🔗 start.gg/umad2026

8 hours ago 9 8 0 0
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Dead On Arrival - Chapter 6: Rebirth The best place for Dead On Arrival - Chapter 6: Rebirth brackets, streams, standings and schedules all in one place!

I will selling at DEAD ON ARRIVAL this Saturday! www.start.gg/tournament/d...

21 hours ago 4 2 0 0
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An old one but a cute one

12 hours ago 527 81 4 0

Would it shock you all to learn that John Sczcepaniak and his family were living in and beneficiaries of apartheid South Africa in his youth

11 hours ago 167 51 15 2

When I say gamers treat you not buying the entertainment products they like with the exact same degree of pain like you chopped off one of their fingers, this is what I mean.

12 hours ago 1457 478 42 29
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ミリちゃん(心持ち多い目)

11 hours ago 575 184 4 0
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Spent Saturday with President Obama and New York's Cutest — turns out my first name is Mayor and I need to be doing more squats. 

Here’s to building a City where families can thrive and every classroom is full of this much joy.

11 hours ago 15621 2350 358 281

I always thought Sun Tzu's "Art of War" was a little simplistic and obvious but it turns out yes, you do literally need to tell the Secretary of War "you need to feed your troops and keep them from being wiped out by preventable diseases"

13 hours ago 2435 454 34 9
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rkgk

13 hours ago 246 88 1 1
Video: ‘Homophobic’ 6-Week-Old Baby Cries After Gay Dad Tells Him ‘There Is No Mama’

Video: ‘Homophobic’ 6-Week-Old Baby Cries After Gay Dad Tells Him ‘There Is No Mama’

Maybe we'll keep some InfoWars content up.

1 day ago 20857 2311 333 55
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The Second Life of Moon Child – A Conversation with Metin Seven 1997 PC platformer Moon Child recently got a bump of attention after Games That Weren't posted gameplay featuring its ear-worm theme song. The game, only released in the Netherlands for PC via CD-ROM

Moon Child is all the rage on Bluesky, but why didn't anyone know about it until now? @john.gamesline.net spoke to @seven.eurosky.social about the viral platformer's second life, as well as the hurdles game developers had in their way during the Commodore Amiga days. gamesline.net/the-second-l...

1 day ago 308 134 3 4

Alex Jones is truly one of the most evil people alive. He's lucky he lives in an era where the punishment for behavior like his is losing your website and not thumbscrews.

1 day ago 1078 190 12 3
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The Columbine massacre was on this date in 1999. Instead of energizing our country to get gun violence under control, it kicked off a new normal. One of the best explanations ever of journalism's destructive impact on mass shootings came from Roger Ebert in his review of Gus Van Sant’s “Elephant.”

1 day ago 5009 1747 30 65
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2 weeks ago 4347 1674 32 27
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1 day ago 10 2 0 0

With the help of the Sandy Hook families, The Onion has reached a long-awaited deal to take over InfoWars.

We've enlisted the help of @timheidecker.bsky.social, who will be InfoWars' Creative Director.

Please stand by for more.

1 day ago 33396 8005 837 1017
Star Trek The Original Series scene. We're in a CORRIDOR! A room door is open, and we see two crewmen spilling out into the hallway in red and blue uniforms. They are otherwise indecipherable tho because they are entirely enveloped in a big cloud of smoke. It's pouring out all around them and into the hallway area, like there's a Phish concert in there. Closed caption reads, "[COUGHING]"

Star Trek The Original Series scene. We're in a CORRIDOR! A room door is open, and we see two crewmen spilling out into the hallway in red and blue uniforms. They are otherwise indecipherable tho because they are entirely enveloped in a big cloud of smoke. It's pouring out all around them and into the hallway area, like there's a Phish concert in there. Closed caption reads, "[COUGHING]"

1 day ago 4039 1376 51 108
Infowars/Onion combo logo in rainbow saying “I support the onion’s hostile media takeover.”

Infowars/Onion combo logo in rainbow saying “I support the onion’s hostile media takeover.”

It’s finally happened. After 18 months. Finally, a media merger you can root for.

1 day ago 22925 4308 148 135

Browsing this company's website and the only way I can describe what I'm seeing is imagine a school shooter was a management consultant

2 days ago 8115 1575 23 17
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@bigyellowsilly.bsky.social Your impact from that one stream announcement image is insane

3 days ago 1112 280 4 2
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OK HERE! #TMNTXJL $fgc #IKEMEN #indiedev #tmnt #dccomics download in the quoted post.

4 days ago 45 21 1 1
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Iron Galaxy Studios: "A number of teammates and friends are losing their jobs as we adjust to a new company structure" www.gamedeveloper.com/business/iro...

4 days ago 158 59 16 29
ABSTRACT
Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins.
In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae.
Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV.
Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose.
Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion.
These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.

ABSTRACT Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV. Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose. Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion. These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.

Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️

4 days ago 394 102 6 8

GOOD NEWS! Researchers have made a HUGE breakthrough towards a UNIVERSAL antiviral. By targeting sugar molecules found on the surface of many viruses that SHARE structural similarities, they identified FOUR compounds that successfully BLOCKED infections from SEVEN different viruses.

4 days ago 3521 1041 42 47
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also this is a funny admission because yeah it's totally correct

most gacha games would not hold up as playable offline titles because most gacha games are bad! they are bad games that completely cease to have functional loops once the gambling is removed

4 days ago 294 102 9 0
A photo of blossoming pink flower buds and a headline that reads “ECONOMIC POLICY - On Tax Day, Mamdani
Taxed the Rich -  The mayor, his supporters, and public opinion convinced their previously reluctant governor to agree to a tax on the second (or third, fourth, fifth, etc.) homes of their city's nonresident rich.”

A photo of blossoming pink flower buds and a headline that reads “ECONOMIC POLICY - On Tax Day, Mamdani Taxed the Rich - The mayor, his supporters, and public opinion convinced their previously reluctant governor to agree to a tax on the second (or third, fourth, fifth, etc.) homes of their city's nonresident rich.”

A photo of a child reaching for blossoming pink flower buds and a headline that reads “Mayor Mamdani Unveils 7 New NYC Early Ed Centers”

A photo of a child reaching for blossoming pink flower buds and a headline that reads “Mayor Mamdani Unveils 7 New NYC Early Ed Centers”

A photo of of blossoming pink flower buds and a headline that reads “New York City to open municipal grocery store in 2027 -  The store will be one of five city-owned food stores Mayor Zohran Mamdani has promised to debut before his term ends.”

A photo of of blossoming pink flower buds and a headline that reads “New York City to open municipal grocery store in 2027 - The store will be one of five city-owned food stores Mayor Zohran Mamdani has promised to debut before his term ends.”

Blossoming pink flower buds near a trash container and a headline that reads “Mamdani To Fully Fund Trash
Containerization -  The new mayor is restarting the Trash Revolution”

Blossoming pink flower buds near a trash container and a headline that reads “Mamdani To Fully Fund Trash Containerization - The new mayor is restarting the Trash Revolution”

Change is in the air, New York. Here are a few things blooming.

4 days ago 2741 427 47 39

IF GOD HAD WANTED YOU TO LIVE HE WOULD NOT HAVE CREATED ME

4 days ago 1222 356 2 0
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The American gestapo abducted an 85 year-old widow.

Was she one of the worst of the worst? No, her step-son, a retired Alabama state trooper, got ICE to put her in a detention center to deport her because he wanted all of his father's inheritance.

Sounds like the son is the worst of the worst.

4 days ago 10070 4571 686 349
chipp mii saying "sushi! sukiyaki! banzai!" that is such a ME thing to say!

chipp mii saying "sushi! sukiyaki! banzai!" that is such a ME thing to say!

4 days ago 41 20 3 0
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