Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models npj Biofilms and Microbiomes - Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models

One should raise awareness on the importance and problems caused by biofilms in clinical situations, highlighting the need to develop better strategies to combat biofilms.
See why by reading our last story leaded by Dr Yutaka Yoshii here:
rdcu.be/e3tJa

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Serotype swapping in Klebsiella spp. by plug-and-play Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

And here it is, the completed BASEL collection finally published as early access in @plosbiology.org - see the thread for more details. 🤗🧬🎣

Phage therapy for Klebsiella pneumoniae: Understanding bacteria–phage interactions for therapeutic innovations Klebsiella pneumoniae (KP) is a Gram-negative bacterium that commonly resides in the human gastrointestinal tract and can also act as an opportunistic pathogen and cause extra-intestinal infections. K...

Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...

We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...

Please share!

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky

A French song 😁

m.youtube.com/watch?v=ZAmO...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

research.pasteur.fr/en/call/call...

Women scientists: inspiring faces of research at the Institut Pasteur The International Day of Women and Girls in Science 2025 is an opportunity to shine the spotlight on committed and talented women researchers. In addition to their scientific work, these Institut Past...

👩‍🔬 On this #WomenInScience Day 2025, we celebrate the inspiring female scientists at Institut Pasteur! More than researchers, they make science accessible to all. 🌍✨

Find out here what our scientists were recently up to : www.pasteur.fr/en/research-...

Let’s continue to amplify their voices 🚀

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

research.pasteur.fr/en/call/call...

American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12

Welcome to the official Bluesky page of the Institut Pasteur!

🔬 Explore with us the frontiers of biomedical research

🧪 Follow us to uncover groundbreaking discoveries

💡 Share knowledge for global health

🌍 Join a community passionate about progress and open science.

Vaccines save lives.

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

Congrats Géraldine! well deserved !👏🎉

Bravo Aude !!

2 days left. Asst/Assoc Prof position in bacteriology, Université de Montréal. Deadline ***Nov. 15*** come join our growing community of bacteriologists. BTW Canada is the USA’s Bluesky!

Identification of Veillonella parvula and Streptococcus gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure | mBio Our research explores the mechanisms of bacterial adhesion within the dental plaque, focusing on Veillonella parvula, a key player in the oral microbiome. Dependent on lactate from streptococci, V. pa...

Our last story is in mBio !(tinyurl.com/h83mh8vy).
Oral bacteria often form mixed species biofilms where aggregation drives interspecies interactions.
Here we investigated Veillonella parvula aggregation with other bacteria and identified molecular actors at the base of such specific interactions!

Diderm Firmicutes strike again! "The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking"
Another beautiful story on the bacterial envelope with @chrisbel70.bsky.social @jmghigolab.bsky.social out today! rdcu.be/drNQ3 #MicroSky

Our story on the Maintenance of Lipid Asymmetry (Mla) system in the amazing Veillonella parvula and in the whole bacterial diversity it now out in Nature Communications.

Check it out!
rdcu.be/drNQ3.
#bacterial cell envelope
@sgribaldo.bsky.social @jmghigolab.bsky.social

Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes - Na... Outer membrane tethering is important for cell envelope integrity in diderm bacteria. Here, the authors present structures and functional analyses of the stalked porin OmpM, which is the main outer me...

Our paper on structural and functional characterisation of OmpM, the predominant outer membrane tethering system in Terrabacteria, is now out!

Great collaboration between @sgribaldo.bsky.social Christophe Beloin @sykhalid.bsky.social and Bert van den Berg groups.

www.nature.com/articles/s41...

Components of iron–Sulfur cluster assembly machineries are robust phylogenetic markers to trace th... The symbioses that gave rise to primary organelles are key events in the origin of Eukaryotes. This study uses a dataset of markers belonging to two conserved machineries responsible for [Fe-S] cluste...

Iron-Sulfur clusters are essential protein co-factors in eukaryotes and are synthesized in mitochondria and plastids by ISC and SUF systems. Can we use these machineries to investigate the origins of organelles? Happy to share our short report out today! #MicroSky
journals.plos.org/plosbiology/...